NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR

灵长类社会行为的神经生物学

• 批准号: 8172499
• 负责人: David G Amaral
• 金额: $ 11.41万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172499
• 关键词: Acoustics; Adult; Age; Amygdaloid structure; Animal Behavior; Behavior; Brain; Computer Retrieval of Information on Scientific Projects Database; Development; Fright; Funding; Genetic; Grant; Hippocampus (Brain); Ibotenic Acid; Image; Infant; Institution; Investigation; Lesion; Macaca; Maternal Behavior; Methods; Monkeys; Neurobiology; Primates; Process; Protocols documentation; Research; Research Personnel; Resources; Role; Social Behavior; Social Interaction; Source; United States National Institutes of Health; frontal lobe; mature animal; prepulse inhibition; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Specific Aims of this project are as follows: Specific Aim 1  To continue investigations of the socioemotional development of monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 2  To evaluate the sexual and maternal behavior in monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 3  To use acoustic startle tasks such as fear potentiated startle and prepulse inhibition to investigate the effect of permanent lesions and transient inactivation of the amygdala on components processes of fear behavior. Specific Aim 4  To use microPET imaging to examine brain plasticity resulting from ibotenic acid lesions of the amygdala in the adult and infant monkeys. Specific Aim 5  To use microPET imaging to investigate potential neural substrates for increased fear behavior by animals who received amygdala lesions as infants during dyadic social interactions and for increased social behavior for adult animals with amygdala lesions. Specific Aim 6  To use a genetic method for reversible inactivation of the amygdala to replicate the effects of permanent amygdala lesions on socioemotional behavior. Specific Aim 7  To use protocols developed to investigate social behavior in the macaque monkey during the current funding period to investigate the roles of two regions of the frontal lobe in social behavior.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的具体目标如下： 具体目标1  继续研究在两周龄时接受鹅膏蕈氨酸杏仁核或海马损伤的猴子的社会情感发育。 具体目标2  评价在两周龄时接受鹅膏蕈氨酸杏仁核或海马损伤的猴的性行为和母性行为。 具体目标3  采用恐惧强化惊吓和前脉冲抑制等听觉惊吓任务，探讨杏仁核永久性损伤和短暂性失活对恐惧行为各成分加工的影响。 具体目标4  利用microPET成像检查成年和幼年猴杏仁核鹅膏蕈氨酸损伤引起的脑可塑性。 具体目标5  使用microPET成像研究在二元社会互动期间婴儿期接受杏仁核损伤的动物增加恐惧行为的潜在神经基质，以及杏仁核损伤的成年动物增加社会行为的潜在神经基质。 具体目标6  利用遗传学方法对杏仁核进行可逆性失活，以复制永久性杏仁核损伤对社会情绪行为的影响。 具体目标7  在当前资助期间，使用研究猕猴社会行为的方案，研究额叶两个区域在社会行为中的作用。