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ROLE OF IMMUNE ACTIVATION IN SIV PATHOGENESIS

ROLE OF IMMUNE ACTIVATION IN SIV PATHOGENESIS
免疫激活在 SIV 发病机制中的作用
批准号:
8172549
负责人:
JOSEPH M MCCUNE
金额:
$15.21万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-06-01 至 2011-04-30

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中文摘要
翻译
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 本研究的目的是确定1)调节性T细胞在SIV发病机制中的作用,2)调节性T细胞的体内扩增及其对SIV发病机制的影响,以及3)Treg频率和功能的依赖性差异。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study are to identify 1) the role of regulatory T cells in SIV pathogenesis, 2) In vivo expansion of regulatory T cells and its effect on SIV pathogenesis, and 3) Age-dependent differences in Treg frequencies and function.
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