ROLE OF IMMUNE ACTIVATION IN SIV PATHOGENESIS

免疫激活在 SIV 发病机制中的作用

• 批准号: 8357276
• 负责人: JOSEPH M MCCUNE
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357276
• 关键词: California; Frequencies; Funding; Grant; National Center for Research Resources; Pathogenesis; Primates; Principal Investigator; Regulatory T-Lymphocyte; Research; Research Infrastructure; Resources; Role; SIV; Source; United States National Institutes of Health; age related; cost; immune activation; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of this study are to identify 1) the role of regulatory T cells in SIV pathogenesis, 2) In vivo expansion of regulatory T cells and its effect on SIV pathogenesis, and 3) Age-dependent differences in Treg frequencies and function.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是确定1）调节性T细胞在SIV发病机制中的作用，2）调节性T细胞的体内扩增及其对SIV发病机制的影响，以及3）Treg频率和功能的依赖性差异。