Administrative Core

湾区丙型肝炎合作研究中心（湾区HCV中心）将使用切割边缘 在精心设计和多样化的回顾性病例对照的背景下， 前瞻性的五个临床队列研究人类对HCV的免疫应答。我们想问一个问题： 为什么有些人对标准治疗反应良好，而有些人则不然？为了解决这个问题，该中心将组建一个强大的多学科团队，由旧金山加州大学（弗朗西斯科总医院、加州大学医学中心和弗朗西斯科退伍军人事务医学中心）、加州太平洋医学中心、血液系统研究所和北方加州Kaiser Permanente的三个不同研究中心的免疫学家和临床研究人员组成。这种焦点和地点的多样性需要一个强有力的 行政和组织结构，以成功地促进方案与 元素 行政核心将促进中心的整体组织结构和行政活动，与NIH NIAID工作人员进行交流，促进项目和核心之间的合作，鼓励科学家提出批评和建议，促进财政责任，并提供灵活的行政结构，以确保中心的卓越性及其实现特定目标的能力。 具体而言，行政核心将：（1）提供一个组织和方案结构， 促进科学互动;（2）提供监督和规划，设定优先事项，并建立决策程序;（3）确保中心符合多项目合作协议（U19）赠款机制的所有标准。

The Bay Area Hepatitis C Cooperafive Research Center (Bay Area HCV Center) will use cutfing-edge immunologic technologies in the context of well-designed and diverse retrospective case-control and prospecfive clinical cohorts to study the human immune response to HCV. We wish to ask the question: why is it that some respond well to standard-of-care therapy and some do not? To address this question, the Center will assemble a strong mulfidisciplinary team comprised of immunologists and clinical investigators at three different sites associated with the University of California at San Francisco (San Francisco General Hospital, UC Medical Center, and the San Francisco Veterans Affairs Medical Center), the California Pacific Medical Center, the Blood Systems Research Institute, and Kaiser Permanente of Northern California. Such diversity in focus and in locafion requires a strong administrafive and organizafional structure to successfully promote synergy between the programmafic elements. The Administrative Core will facilitate the overall organizational structure and administrafive activities of the Center, interface with NIH NIAID staff, foster cooperafion between projects and cores, encourage crificism and advice from its scientists, promote fiscal responsibility, and provide a flexible administrative structure to assure the confinued excellence of the Center and its ability to address the Specific Aims. Specifically, the Administrative Core will: (1) provide an organizafional and programmatic structure to promote scientific interactions; (2) provide oversight and planning, set priorities, and establish decisionmaking processes; and (3) ensure that the Center meets all criteria of the multi-project Cooperative Agreement (U19) grant mechanism.