Conformal Sealant for Burn Wound Repair

用于修复烧伤创面的敷形密封剂

• 批准号: 7793722
• 负责人: Weiliam Chen
• 金额: $ 18.52万
• 依托单位: ENDOMEDIX, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793722
• 关键词: Accident and Emergency department; Acute; Address; Admission activity; Anti-Bacterial Agents; Antibiotics; Bacitracin; Biocompatible; Burn injury; Caring; Child; Cicatrix; Contracture; Cream; Dermal; Dermis; Drug Formulations; Esthetics; Family suidae; Goals; Healed; Hospitals; Hydrogels; In Vitro; Infection prevention; Injury; Intention; Medical center; Modeling; Occlusive Dressings; Patients; Property; Recommendation; Sepsis; Side; Speed; Sterile coverings; Testing; Text; Thick; Time; Tissues; Topical Antibiotic; Validation; Visit; Wound Healing; age group; bactericide; base; biomaterial compatibility; cell type; cytotoxicity; functional disability; healing; improved; in vivo; mortality; public health relevance; seal; standard care; statistics; validation studies; wound

DESCRIPTION (provided by applicant): Deep partial thickness burns involve the deeper layers of the dermis, and usually do not heal for at least 2 to 3 weeks. This often results in significant scarring and contractures, especially in children. There is no established standard treatment for deep partial thickness burns. In general, they may be covered with an occlusive dressing or a topical antimicrobial (e.g., Silvadene or bacitracin) cream and an absorptive dressing; evidently, these are all applied on an ad hoc basis and none of them promotes healing. The unmet challenge of burn treatment is to devise a remedy that prevents infection, speeds healing and reduces scarring. In this project, we will formulate a formable/conformable antibacterial tissue sealant dressing specific for treating burn wounds. In parallel, we will validate the lack of cytotoxicity potential of each tissue sealant formulation using model cell types that the hydrogel will most likely be in close contact upon deployment, to be followed by in vivo biocompatibility testing. The anti-bacterial activities will also be tested, to be followed by an in vivo efficacy validation study in porcine dermal burns. PUBLIC HEALTH RELEVANCE: Burns are one of the most common causes of injury in all age groups. The primary goals of acute burn wound management are prevention of infection and the promotion of optimal wound closure by re-epithelialization to minimize aesthetic and functional impairment. Deep partial thickness burns involve the deeper layers of the dermis, and usually do not heal for at least 2 to 3 weeks. This often results in significant scarring and contractures, especially in children. There is no established standard treatment for deep partial thickness burns. In general, these burns may be covered with an occlusive dressing or a topical antimicrobial (e.g., Silvadene or bacitracin) cream and an absorptive dressing; evidently, these are all applied on an ad hoc basis and none of them promotes healing. The unmet challenge of burn treatment is to devise a remedy that prevents infection, speeds healing and reduces scarring. It is our intention to develop an antibacterial tissue sealant capable of sealing the burn wound, preventing infection, accelerating wound healing and reducing scarring.

描述(申请人提供)：深度部分烧伤累及真皮较深层，通常至少2至3周内不会愈合。这往往会导致严重的疤痕和痉挛，特别是在儿童中。深度烧伤的标准治疗方法尚无定论。一般来说，可以用封闭敷料或局部抗菌(如西瓦丁或杆菌肽)乳膏和吸收敷料覆盖它们；显然，这些都是临时应用的，它们都不能促进愈合。烧伤治疗尚未解决的挑战是设计一种预防感染、加速愈合和减少疤痕的药物。在本项目中，我们将研制一种用于治疗烧伤创面的可成形/可适应抗菌组织密封剂敷料。同时，我们将使用水凝胶在部署时最有可能密切接触的模型细胞类型来验证每种组织密封剂配方是否缺乏细胞毒性潜力，然后进行体内生物兼容性测试。还将测试其抗菌活性，随后将进行猪皮肤烧伤的体内疗效验证研究。 公共卫生相关性：烧伤是所有年龄段最常见的伤害原因之一。急性烧伤创面处理的主要目标是预防感染和通过再上皮化促进创面的最佳闭合，以最大限度地减少美学和功能损害。深度部分烧伤累及真皮较深层，通常至少2至3周内不会愈合。这往往会导致严重的疤痕和痉挛，特别是在儿童中。深度烧伤的标准治疗方法尚无定论。一般来说，这些烧伤可以用封闭敷料或局部抗菌(如西尔瓦丁或杆菌肽)乳膏和吸收敷料覆盖；显然，这些都是临时使用的，都不能促进愈合。烧伤治疗尚未解决的挑战是设计一种预防感染、加速愈合和减少疤痕的药物。我们的目的是开发一种能够封闭烧伤创面、防止感染、加速创面愈合和减少瘢痕形成的抗菌组织密封剂。