Automatic Compilation and Optimization for Programmable Lab on a Chip

可编程片上实验室的自动编译和优化

• 批准号: 8000975
• 负责人: Ahmed Amin
• 金额: $ 12.5万
• 依托单位: MICROFLUIDIC INNOVATIONS, LLC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8000975
• 关键词: Address; Adoption; Biological Assay; Code; Collaborations; Computers; Custom; Development; Devices; Engineering; Heating; Industry; Instruction; Knowledge; Language; Life; Liquid substance; Marketing; Microfluidics; Microprocessor; Minor; Modification; Phase; Procedures; Process; Productivity; Protocols documentation; Pump; Research Infrastructure; Resources; Running; Scientist; Small Business Innovation Research Grant; System; Techniques; Technology; Testing; Time; Translating; Writing; cost; design; flexibility; innovation; micro-total analysis system; new technology; prevent; programs; public health relevance; research study; sensor

DESCRIPTION (provided by applicant): Current LoCs are assay-specific and are custom-built for each single experiment. Performing an experiment requires life scientists to endure the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. Moreover, life scientists exploring new assay protocols require either intensive background knowledge in microfluidic technology and fabrication procedures, or need close collaboration with a microfluidic engineer, thereby hindering productivity. To relieve the life scientist from this aggravation, Microfluidic Innovations will develop a multi-purpose, programmable Lab-on-a-Chip (PLoC), where the life scientist will simply write or download a program for each experiment. This multi-purpose device and programmable platform eliminates the need for a new design for each assay, allowing the life scientist to focus more on assay design than chip design. Unlike existing commercial chips from competitor companies that provide either application-specific LoCs, batch processing LoCs, or limited, single-use chips, Microfluidic Innovations' devices expose the programming interface to the assay-writer, and provide the flexibility and versatility required to explore and develop new assays. Just as programmability and general-purpose computing have revolutionized the computer industry, Microfluidic Innovations' PLoC platform will provide a paradigm shift for the microfluidic LoC industry. The purpose of this project is to develop an automatic compiler and runtime infrastructure that would significantly ease the development of new assays in an easy-to-understand, high-level language, and would reduce barriers to the adoption of this new technology by life scientists. The compiler would automatically address issues such as fluid distribution and contamination, and a modular, scalable runtime system would automatically orchestrate the execution of instructions on different PLoC devices. PUBLIC HEALTH RELEVANCE: Microfluidic Innovations will develop a multi-purpose, programmable Lab-on-a-Chip (PLoC), where the life scientist will simply write or download a program for each experiment. This multi-purpose device and programmable platform eliminates the need for a new design for each assay, allowing the life scientist to focus more on assay design than chip design. This proposal aims to develop a full automatic compiler and optimization infrastructure that will make it easier for assay-writers to develop new protocols and reduce barriers to market adoption of PLoC devices.

描述（由申请方提供）：当前的LoC是特定于检测试剂盒的，并且是针对每个单一实验定制的。进行实验需要生命科学家在进行实际实验之前忍受设计，制造和测试芯片的耗时过程。这一漫长的周期可能需要数月才能完成，增加了工作量和成本，降低了生产力。类似地，对测定方案的微小修改重新引起设计周期的开销。此外，探索新的分析方案的生命科学家需要在微流体技术和制造过程中的大量背景知识，或者需要与微流体工程师密切合作，从而阻碍生产力。为了减轻生命科学家的这种恶化，微流体创新公司将开发一种多用途、可编程的芯片实验室（PLoC），生命科学家只需为每个实验编写或下载一个程序。这种多用途设备和可编程平台消除了对每个检测的新设计的需要，使生命科学家能够更多地关注检测设计而不是芯片设计。与竞争对手公司现有的提供特定应用LoC、批处理LoC或有限的一次性芯片的商业芯片不同，Microfluidic Innovations的设备将编程接口暴露给分析作者，并提供探索和开发新分析所需的灵活性和多功能性。正如可编程性和通用计算已经彻底改变了计算机行业一样，Microfluidic Innovations的PLoC平台将为微流体LoC行业提供范式转变。该项目的目的是开发一种自动编译器和运行时基础设施，这将大大简化以易于理解的高级语言开发新检测方法的工作，并减少生命科学家采用这种新技术的障碍。编译器将自动解决诸如流体分布和污染等问题，并且模块化、可扩展的运行时系统将自动协调不同PLoC设备上的指令执行。 公共卫生相关性：Microfluidic Innovations将开发一种多用途的可编程芯片实验室（PLoC），生命科学家只需为每个实验编写或下载一个程序。这种多用途设备和可编程平台消除了对每个检测的新设计的需要，使生命科学家能够更多地关注检测设计而不是芯片设计。该提案旨在开发一个全自动编译器和优化基础设施，使分析作者更容易开发新的协议，并减少市场采用PLoC设备的障碍。

项目成果

Software-programmable continuous-flow multi-purpose lab-on-a-chip.

• DOI: 10.1007/s10404-013-1180-2
• 发表时间: 2013-11
• 期刊: MICROFLUIDICS AND NANOFLUIDICS
• 影响因子: 2.8
• 作者: Amin, Ahmed M.;Thakur, Raviraj;Madren, Seth;Chuang, Han-Sheng;Thottethodi, Mithuna;Vijaykumar, T. N.;Wereley, Steven T.;Jacobson, Stephen C.
• 通讯作者: Jacobson, Stephen C.