Diabetes Therapies from Adipose Derived Stem Cells

脂肪干细胞的糖尿病治疗

• 批准号: 7992863
• 负责人: YOLANDA Renee LEA-CURRIE
• 金额: $ 36.32万
• 依托单位: ZEN-BIO, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7992863
• 关键词: Acute; Adipocytes; Adipose tissue; Affect; Amino Acids; Applications Grants; Autologous Transplantation; Biology; Biopsy; Blood Glucose; Bone Marrow; Cell Culture Techniques; Cell Fraction; Cell Lineage; Cell Therapy; Cell surface; Cells; Clinical Research; Collection; Data; Diabetes Mellitus; Disease; Disease Progression; Endothelial Cells; Environment; Etiology; Excision of redundant skin of eyelid; Fatty acid glycerol esters; Glucagon; Glucose; Goals; Hormones; Human; Incidence; Insulin; Life; Mesenchymal; Metabolic Control; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Operative Surgical Procedures; Pancreas; Pancreatic Polypeptide; Pharmaceutical Preparations; Phase; Population; Prevalence; Procedures; Process; Production; Protocols documentation; Recording of previous events; Research; Serum; Small Business Innovation Research Grant; Somatostatin; Source; Staging; Stem cells; Structure of beta Cell of islet; Suction Lipectomy; Surgeon; Techniques; Therapeutic; Tissues; Work; adult stem cell; bariatric surgery; blood glucose regulation; cell type; diabetes mellitus therapy; diabetic; drug development; experience; ghrelin; glucagon-like peptide 1; glycemic control; insulin secretagogues; insulin secretion; islet; mortality; new technology; prevent; public health relevance; research study; response; stem cell population; type I and type II diabetes

DESCRIPTION (provided by applicant): Diabetes affects the lives of hundreds of millions of people worldwide and the incidence rate is continuing to rise. About 8% of the US population is estimated to have Type 1 or Type 2 diabetes, with the prevalence of Type 2 diabetes increasing with the rise in obesity. Even though the etiology of Type 1 and Type 2 diabetes is different, the end stages show a similar reduction or loss of pancreatic insulin secretion. This is caused by destruction of the pancreatic beta cells which produce and secrete insulin in response to serum glucose levels. Current diabetes therapies do not offer the degree of metabolic control needed to prevent the progression of the disease to the serious complications and mortality that occur when glucose control is lost. The potential for excellent, long-term glycemic control offered by a "beta-like", insulin producing cell is the rationale for our proposal. This cell would release insulin in a physiologically controlled, glucose-dependent manner, responding minute-to-minute to acute changes in blood glucose levels. In this situation, diabetes would be completely controlled. We have obtained significant preliminary data suggesting that adipose-derived stem cells can be differentiated in culture to "beta-like" insulin producing cells, and propose to develop applications of these cells for use in cell therapy and drug development. It is our goal to identify and characterize an optimized adult stem cell population from human adipose tissue that has the therapeutic potential for the treatment of diabetes. PUBLIC HEALTH RELEVANCE: Current diabetes therapies do not offer the degree of metabolic control needed to prevent the progression of the disease to the serious complications and mortality that occur when glucose control is lost. Our objective is to identify and characterize an adult stem cell population from human adipose tissue that has the therapeutic potential to differentiate into insulin-secreting pancreatic "beta-like" cells. If successful, this work would offer the possibility for cell treatment and possible cure of type 1 and type 2 diabetes.

描述（由申请人提供）：糖尿病影响着全世界数亿人的生活，而且发病率还在持续上升。据估计，大约8%的美国人患有1型或2型糖尿病，随着肥胖的增加，2型糖尿病的患病率也在增加。尽管1型和2型糖尿病的病因不同，但最终阶段胰腺胰岛素分泌减少或减少的情况相似。这是由胰腺细胞的破坏引起的，胰腺细胞根据血清葡萄糖水平产生和分泌胰岛素。目前的糖尿病治疗不能提供所需的代谢控制程度，以防止疾病发展到严重的并发症和死亡，当血糖控制失去时发生。一种“β样”胰岛素生成细胞提供了极好的长期血糖控制的潜力，这是我们提出这一建议的基本原理。这种细胞会以一种生理控制的、葡萄糖依赖的方式释放胰岛素，每分钟对血糖水平的急性变化做出反应。在这种情况下，糖尿病将被完全控制。我们已经获得了重要的初步数据，表明脂肪来源的干细胞可以在培养中分化为“β样”胰岛素产生细胞，并建议将这些细胞用于细胞治疗和药物开发。我们的目标是从具有治疗糖尿病治疗潜力的人类脂肪组织中鉴定和表征一个优化的成体干细胞群。