用于药物筛选的脑癌异种移植模型-猫眼课题宝

用于药物筛选的脑癌异种移植模型

批准号：

7907320

负责人：

Chunqi Li

金额：

$19.2万

依托单位：

PHYLONIX PHARMACEUTICALS, INC.

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-05-07 至 2011-11-30

来源：

https://reporter.nih.gov/project-details/7907320

关键词：

Accounting Adult Animal Model Animals Antineoplastic Agents Astrocytoma Brain CM-DiI Cancer Model Cancer cell line Cell Line Cell Proliferation Cells Cerebral Ventricles Data Development Disease Drug Combinations Dyes Enzyme-Linked Immunosorbent Assay Evaluation FDA approved Glioblastoma Government Human Immunodeficient Mouse Injection of therapeutic agent Label Libraries Life Malignant - descriptor Malignant Neoplasms Malignant neoplasm of brain Mammals Modeling Mus Neoplasm Metastasis Persons Pharmaceutical Preparations Pharmacologic Substance Phase Play Preclinical Drug Evaluation Proliferating Publishing Rattus Research Role Screening procedure Site System Visual Xenograft procedure Zebrafish angiogenesis anticancer research base brain cell cancer cell cost drug candidate hindbrain human migration in vivo medulloblastoma novel public health relevance tumor progression

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DESCRIPTION (provided by applicant): In this research, we will develop zebrafish as a new xenotransplant animal model to assess brain cancer progression and identify potential drug candidates. Brain cancer accounts for approximately 10 - 30% of adult cancers and many forms of cancer can metastasize to the brain. Although immunodeficient mice and rats have played an important role as hosts for brain cancer xenografts, a simple and cost-effective orthotopic brain cancer model is required for more efficient in vivo cancer drug screening. PUBLIC HEALTH RELEVANCE: In this research, we propose to develop zebrafish as a new xenotransplant animal model to assess brain cancer progression, identify potential drug candidates, and rank efficacy.

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