Brain Cancer Xenotransplant Model for Drug Screening
用于药物筛选的脑癌异种移植模型
基本信息
- 批准号:7907320
- 负责人:
- 金额:$ 19.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-07 至 2011-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdultAnimal ModelAnimalsAntineoplastic AgentsAstrocytomaBrainCM-DiICancer ModelCancer cell lineCell LineCell ProliferationCellsCerebral VentriclesDataDevelopmentDiseaseDrug CombinationsDyesEnzyme-Linked Immunosorbent AssayEvaluationFDA approvedGlioblastomaGovernmentHumanImmunodeficient MouseInjection of therapeutic agentLabelLibrariesLifeMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of brainMammalsModelingMusNeoplasm MetastasisPersonsPharmaceutical PreparationsPharmacologic SubstancePhasePlayPreclinical Drug EvaluationProliferatingPublishingRattusResearchRoleScreening procedureSiteSystemVisualXenograft procedureZebrafishangiogenesisanticancer researchbasebrain cellcancer cellcostdrug candidatehindbrainhuman migrationin vivomedulloblastomanovelpublic health relevancetumor progression
项目摘要
DESCRIPTION (provided by applicant): In this research, we will develop zebrafish as a new xenotransplant animal model to assess brain cancer progression and identify potential drug candidates. Brain cancer accounts for approximately 10 - 30% of adult cancers and many forms of cancer can metastasize to the brain. Although immunodeficient mice and rats have played an important role as hosts for brain cancer xenografts, a simple and cost-effective orthotopic brain cancer model is required for more efficient in vivo cancer drug screening.
PUBLIC HEALTH RELEVANCE: In this research, we propose to develop zebrafish as a new xenotransplant animal model to assess brain cancer progression, identify potential drug candidates, and rank efficacy.
描述(由申请人提供):在这项研究中,我们将开发斑马鱼作为一种新的异种移植动物模型,以评估脑癌进展并确定潜在的候选药物。脑癌约占成人癌症的10 - 30%,许多形式的癌症可以转移到大脑。尽管免疫缺陷小鼠和大鼠作为脑癌异种移植物的宿主发挥了重要作用,但需要一种简单且具有成本效益的原位脑癌模型来进行更有效的体内癌症药物筛选。
公共卫生相关性:在这项研究中,我们建议开发斑马鱼作为一种新的异种移植动物模型,以评估脑癌进展,识别潜在的候选药物,并对疗效进行排名。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chunqi Li其他文献
Chunqi Li的其他文献
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{{ truncateString('Chunqi Li', 18)}}的其他基金
Phase 2 SBIR: Zebrafish Cytochrome P450 Assays for Assessing Drug Metabolism and
第 2 阶段 SBIR:斑马鱼细胞色素 P450 检测,用于评估药物代谢和
- 批准号:
7848598 - 财政年份:2009
- 资助金额:
$ 19.2万 - 项目类别:
Zebrafish Cytochrome P450 Assays for Assessing Drug Metabolism and Drug Safety
用于评估药物代谢和药物安全性的斑马鱼细胞色素 P450 测定
- 批准号:
7393512 - 财政年份:2008
- 资助金额:
$ 19.2万 - 项目类别:
Phase 2 SBIR: Zebrafish Cytochrome P450 Assays for Assessing Drug Metabolism and
第 2 阶段 SBIR:斑马鱼细胞色素 P450 检测,用于评估药物代谢和
- 批准号:
7613075 - 财政年份:2008
- 资助金额:
$ 19.2万 - 项目类别:
Phase 2 SBIR: Zebrafish Cytochrome P450 Assays for Assessing Drug Metabolism and
第 2 阶段 SBIR:斑马鱼细胞色素 P450 检测,用于评估药物代谢和
- 批准号:
7692940 - 财政年份:2008
- 资助金额:
$ 19.2万 - 项目类别:
In Vivo Zebrafish GFAP ELISA for Neurotoxicity
体内斑马鱼 GFAP ELISA 检测神经毒性
- 批准号:
7482582 - 财政年份:2008
- 资助金额:
$ 19.2万 - 项目类别:
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