User-Friendly System Dynamics Analysis Tools for Translational Mind-Body Research

用于转化身心研究的用户友好的系统动力学分析工具

• 批准号: 7919003
• 负责人: YANHUI LIU
• 金额: $ 29.76万
• 依托单位: DYNADX CORPORATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919003
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DESCRIPTION (provided by applicant): Biomarkers that capture dynamical system processes may be especially valuable and informative in the investigation of complementary and alternative medicine (CAM) therapies, particularly, multi-component mind-body interventions, that simultaneously target several physiological systems. The overall goal of this Phase I SBIR application is to develop a user-friendly software platform that will enable the quantification of system dynamics as well as nonlinear interactions among multiple organ systems that will be particularly suited for the study of complex CAM interventions. To this end, the proposed project assembles a cross-disciplinary team with expertise bridging CAM research, complex system analysis, physiology, and software engineering. The proposed project will focus on the following two specific aims: 1) to develop a user-friendly software platform containing a toolbox of system dynamics analyses with applications suitable for mind-body and CAM therapies. 2) To determine the usability and reliability of the software platform to analyze physiological data from investigations of CAM interventions. The long-term goal of this project is to build an innovative analysis platform that is robust, powerful and easy to use. This new analysis environment will enable CAM and mind-body researchers to apply state-of-the-art quantitative tools for system level dynamical analysis. These new analysis tools will provide objective measurements that are particularly useful for CAM therapies, and thus accelerate translational CAM research. PUBLIC HEALTH RELEVANCE: Complementary and alternative medicine (CAM) and mind-body research often deal with the most complex interventions that are better understood from a system perspective. However, CAM researchers lack necessary analysis tools that can provide objective, quantitative measurements about the system as a whole. We propose to develop a new class of computer tools to provide user-friendly and powerful methods to monitor and evaluate the efficacy of CAM interventions.

描述(由申请人提供)：捕捉动态系统过程的生物标志物在补充和替代医学(CAM)疗法的研究中可能特别有价值和信息，特别是同时针对几个生理系统的多组分心身干预。这一第一阶段SBIR应用的总体目标是开发一个用户友好的软件平台，该平台将能够量化系统动力学以及多个器官系统之间的非线性相互作用，这将特别适合于复杂的CAM干预研究。为此，拟议的项目组建了一支跨学科的团队，具有沟通CAM研究、复杂系统分析、生理学和软件工程的专业知识。拟议的项目将集中于以下两个具体目标：1)开发一个用户友好的软件平台，其中包含一个系统动力学分析工具箱，以及适用于心身和CAM疗法的应用程序。2)确定用于分析CAM干预调查生理数据的软件平台的可用性和可靠性。该项目的长期目标是构建一个健壮、强大、易用的创新分析平台。这一新的分析环境将使CAM和心身研究人员能够应用最先进的量化工具进行系统级的动态分析。这些新的分析工具将提供对CAM疗法特别有用的客观测量，从而加速翻译CAM研究。 公共卫生相关性：补充和替代医学(CAM)和心身研究通常涉及从系统角度更好地理解的最复杂的干预措施。然而，CAM研究人员缺乏必要的分析工具，无法提供关于整个系统的客观、定量的测量。我们建议开发一类新的计算机工具，以提供用户友好和强大的方法来监测和评估CAM干预的效果。