Realtime Monitoring of Trace Amounts of Pesticides from Water Using Carbo
使用 Carbo 实时监测水中痕量农药
基本信息
- 批准号:7809943
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-01 至 2011-02-28
- 项目状态:已结题
- 来源:
- 关键词:AcetylcholinesteraseAcuteAddressAdolescentAffinityAgricultureAirAldehydesAluminumAminesAnimalsAntibodiesAreaArizonaAutomobile DrivingBackBacteriaBindingBiochemistryBiologicalBiosensorBirdsBrainBudgetsCaliberCarbarylCarbonCarbon NanotubesCarcinogensCellsCerealsCessation of lifeChemistryChlorinated HydrocarbonsChlorpyrifosCholinesterasesChronicCommunicationComplexComputer SystemsConflict (Psychology)Congenital AbnormalityCongressesCountryCoupledCulicidaeDataDatabasesDepositionDetectionDevelopmentDevicesDiazinonDisputesDustEconomicsElectrodesElectronicsEndosulfanEngineeringEnvironmentEnvironmental HealthEnzymesEquipmentEquipment ContaminationExposure toFisheriesFishesFoodFundingGoalsGovernmentGrantHealthHumanHuman ResourcesHuman bodyImmobilizationIndividualIngestionInkInorganic SulfatesInsect ControlInsectaInsecticidesInternetIntranetIsomerismKetonesKnowledgeLengthLightLiquid substanceLocationMalathionMarketingMeasurementMeasuresMechanicsMemoryMetabolismMethodsMicroelectrodesMicrofluidicsMineralsMitesModelingMonitorMovementMusNanoarray Analytical DeviceNanotechnologyNerveNervous system structureNeuraxisNeuronsNoiseOceansOregonOrganophosphatesOsteogenesisParasympathomimetic AgentsPerformancePest ControlPesticidesPhasePlantsPlasticsPoisonPricePrincipal InvestigatorPrintingPublic HealthPumpRattusReal-Time SystemsRecordsRecreationResearchResearch PersonnelResistanceRiskRiversRodentRunningSalmonSamplingSensitivity and SpecificityServicesSeveritiesSignal TransductionSoilSolidSolutionsSourceSpecific qualifier valueSpectrum AnalysisSubgroupSurfaceSurveysSymptomsSystemSystems IntegrationTeaTechniquesTechnologyTestingTheftTimeToxic effectTrainingTranslatingTravelTubeUltrasonographyUniversitiesUnspecified or Sulfate Ion SulfatesWashingtonWaterWireless TechnologyWood materialWorkYeastsabsorptionbasecarcinogenicitychemical bondcommercial applicationcommercializationcostcost effectivecross reactivitydesigndrinking waterelectric impedancefruits and vegetablesimprovedinnovationkillingsmalaoxonmanmembermilligrammonitoring devicemulti walled carbon nanotubenanofluidicnanomaterialsnanoscalenanosensorsnew technologyparticlepesticide interactionpressurepreventproduct developmentprogramsprototypepublic health relevancesample collectionsensorspinal cord and brain injurysuperfund sitewastingwater qualitywater sampling
项目摘要
DESCRIPTION (provided by applicant): Development of a Field Applicable Real-time Remote Monitoring Sensor Device Capable of Detecting multiple pesticides simultaneously in fluid or surface water. We propose to use carbon nanotube matrices as the active biosensor area for the effective immobilization of the pesticides through antibody based conjugation. Our initial work has demonstrated sensitivities in the nanogram/ml regime with very low cross reactivity in the detection of the 3 pesticides, Endosulfan sulfate, Edrin aldehyde, edrin ketone.. Principal Investigator: Shalini Prasad Ph. D, Arizona State Phase I (The Sensor): This work, will utilize an ultra sensitive electrochemical sensing platform based on aligned MWCNT for voltammetric analysis of pesticides. We will examine the capability and performance of the carbon nano-array based sensing unit and develop simultaneous and continuous detection of multiple pesticides. Phase One (The System): will develop automated delivery and clearance of fluid samples to the test sensor using a proprietary design for an electronic microfluidic pump mechanism and turbine run recharging unit coupled to pneumatic mechanisms. Application of the Project to Product Development and Commercialization: Statement of the problem. Our nation's water quality is at risk since we cannot afford the man power and time it takes to sample and analyze water using current methods. The risk pesticides pose has been grossly underestimated. A recent study, of the U.S. 2009 Geological survey done by NOAA Fisheries Service and Washington State University, indicates that the combined effect of multiple pesticides is far more dangerous to the health of wildlife and humans than was estimated by analyzing the results for the effect of each pesticide individually1. In fact when juvenile west coast salmon were exposed to only two pesticides at once they immediately died. These were common pesticides used in agriculture that were thought to be safe. This lack in capability of providing water comprehensive testing for the health of the public and aquatic environments is not limited to Oregon; it is a nation wide problem. Solution: A field applicable real-time remote monitoring device to detect pesticides in water would allow DEQ, EPA and NIEH researchers to get enough data on the relationship between environmental and industrial or agricultural factors and specific mechanisms that effect water quality, to effect change. Currently there is not enough data to develop comprehensive and effective plans for managing pesticides. Dahl Natural and Arizona State are partnering to develop feasibility of this technology so that it can be commercialized to provide a solution to this health and environmental threatening problem. Commercial Applications and Other Benefits. Unique to this solution is the ability of this device to be deployed in an aquatic environment for from one to two years without the need for servicing until the end of that time period. In addition the data can be remotely sent to many different data bases at once. Hence the commercial application and benefits to the NIEH and the public are many and include waste water monitoring and alarm systems, superfund site monitoring, timely individual wastewater discharge permits issued, establishment of a comprehensive data base for NIEH, DEQ, EPA and University researchers. The market for pesticide testing is over 1 Billion dollars a year. The low cost of the sensors and dramatic cost saving per test (from $200 to $600 a day per pesticide for one mean sample to over 50 mean samples per day for as little as $30.00) as well as increase access to internet /intranet accessible data. Key Words. Field Applicable Remote Monitoring of Pesticides in Water, Electrochemical Sensor, Self-assembled MWCNT, antibody based conjugation, Endosulfan sulfate, Edrin aldehyde, edrin ketone Summary for Members of Congress. The NIEH has funded a ground breaking research effort which could dramatically improve our nation's ability to detect threats to drinking water, lakes, rivers and ocean aquatic environments. This new technology will be able to remotely monitor toxic pesticides for 1-2 years at a time.
PUBLIC HEALTH RELEVANCE: The goal of this project is to integrate Dahl Natural's sampling system and wireless communication with the expertise of Dr. Shalini Prasad in nanotechnology based sensors using surface functionalized multi-walled carbon nanotube arrays (mats); and, to develop a practical, robust and cost-effective sensing system for routine monitoring of pesticides in surface waters.
描述(由申请人提供):开发一种现场适用的实时远程监测传感器设备,能够同时检测流体或地表水中的多种农药。我们提出利用碳纳米管基质作为活性生物传感器区域,通过抗体偶联技术实现农药的有效固定化。我们的初步工作表明,该方法在纳克/ml范围内具有很低的交叉反应性,可用于检测三种农药,硫丹硫酸盐、黄芩醛、黄芩酮。第一阶段(传感器):这项工作将利用基于对齐MWCNT的超灵敏电化学传感平台进行农药伏安分析。我们将研究基于碳纳米阵列的传感单元的能力和性能,并开发多种农药的同时和连续检测。第一阶段(系统):将使用专有设计的电子微流体泵机构和涡轮运行充电单元与气动机构耦合,开发流体样品到测试传感器的自动输送和清除。项目在产品开发和商业化中的应用:对问题的陈述。我们国家的水质正处于危险之中,因为我们负担不起使用现有方法取样和分析水所需的人力和时间。农药带来的风险被严重低估了。美国国家海洋和大气管理局渔业局和华盛顿州立大学最近对2009年美国地质调查进行的一项研究表明,多种农药的综合影响对野生动物和人类健康的危害远比单独分析每种农药影响的结果所估计的要大。事实上,如果西海岸的鲑鱼幼崽同时接触两种杀虫剂,它们就会立即死亡。这些是农业中常用的农药,被认为是安全的。缺乏为公众健康和水生环境提供全面水检测的能力不仅限于俄勒冈州;这是一个全国性的问题。解决方案:一种现场适用的实时远程监测设备,用于检测水中的农药,将使DEQ、EPA和NIEH的研究人员能够获得足够的数据,了解环境与工业或农业因素之间的关系,以及影响水质的具体机制,从而影响变化。目前还没有足够的数据来制定全面有效的农药管理计划。达尔自然公司和亚利桑那州立大学正在合作开发这项技术的可行性,以便将其商业化,为这一威胁健康和环境的问题提供解决方案。商业应用和其他好处。该解决方案的独特之处在于,该设备可以在水生环境中部署一到两年,在此期间结束之前不需要维修。此外,数据可以一次远程发送到许多不同的数据库。因此,NIEH和公众的商业应用和利益是多方面的,包括废水监测和报警系统,超级基金现场监测,及时发放个人废水排放许可证,为NIEH, DEQ, EPA和大学研究人员建立一个全面的数据库。农药测试的市场每年超过10亿美元。传感器的低成本和每次测试的显著成本节约(从每天一个平均样本的每种农药200至600美元到每天超过50个平均样本的低至30美元)以及增加对互联网/内部网可访问数据的访问。关键字。现场适用的水中农药远程监测,电化学传感器,自组装MWCNT,基于抗体的偶联,硫酸丹,Edrin醛,Edrin酮NIEH资助了一项突破性的研究工作,这项工作将极大地提高我国检测饮用水、湖泊、河流和海洋水生环境威胁的能力。这项新技术将能够一次远程监测有毒农药1-2年。
项目成果
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SHALINI PRASAD其他文献
SHALINI PRASAD的其他文献
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