Acquisition of a 400MHz Solution NMR System with an Autosampler

描述(由申请人提供)：田纳西大学健康科学中心正在申请资金购买一台新的400 MHz核磁共振光谱仪，该光谱仪将取代我们已有17年历史的Bruker ARX-300 MHz核磁共振光谱仪。连同一台配备齐全的用于先进核磁共振实验的500 MHz仪器，该仪器将在园区的共享核磁共振设施中进行管理。该仪器将支持许多正在进行的、由NIH资助的研究项目，这些项目主要集中在小分子药物的发现和药物输送方面。300兆赫核磁共振已被用于常规核磁共振研究的无人值守模式。所要求的新的、简单的双通道解决方案400 MHz核磁共振需要取代老化和技术受限的300 MHz核磁共振。它将配备一个基本的样品交换器和一个宽带探头，可以自动调谐到药物化学中经常遇到的原子核(1H、19F、13C、31P和15N)。与它所取代的旧300核磁共振相比，它提供了更高的灵敏度、更高的吞吐量和更好的性能。它还将为药物化学家提供自动化、常规的二维核磁共振测量能力，为500 MHz核磁共振释放宝贵的仪器时间，这是正在进行的和扩大的NIH支持项目的许多高级实验所需的。主动屏蔽的磁体大大降低了杂散磁场，这将使我们能够更好地利用宝贵的实验室空间。通过NIH资助的这一校园研究发现的几种候选药物已经获得许可，并正在商业化过程中。收购新的400兆赫将大大加强NIH资助的生物医学研究和研究生的培训。田纳西大学健康科学中心坚定地致力于支持生物医学研究，这一事实证明了目前的两台核磁共振仪器都是用该大学的资金购买和良好维护的。

DESCRIPTION (provided by applicant): The University of Tennessee Health Science Center is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our 17-year old Bruker ARX-300 MHz NMR. Together with a well equipped 500 MHz instrument for advanced NMR experiments, this instrument will be managed within the campus's Shared NMR Facility. This instrument will support many on-going, NIH funded research projects that mainly focus on small molecular drug discovery and drug delivery. The 300 MHz NMR has been used for routine NMR studies in a walk-up mode. The requested new, simple two-channel solution 400 MHz NMR is needed to replace the aging and technically limited 300 NMR. It will be equipped with a basic sample changer and one broadband probe that automatically tune to nuclei usually encountered in medicinal chemistry (1H, 19F, 13C, 31P and 15N). It offers significantly greater sensitivity, higher throughput, and substantially better performance compared with the old 300 NMR that it replaces. It will also provide capability for automated, routine two dimensional NMR measurements for medicinal chemists, freeing up valuable instrument time on the 500 MHz NMR which is needed for many advanced experiments for on-going and expanded NIH supported projects. The actively shielded magnet has greatly reduced stray field which will allow us to make better use of valuable lab space. Several drug candidates discovered through NIH funded research on this campus have been licensed and are in the commercialization process. The acquisition of the new 400 MHz will enhance NIH funded biomedical research and the training of graduate students substantially. The University of Tennessee Health Science Center has strong commitment to support biomedical research, as evidenced by the fact that both current NMR instruments were purchased and well maintained with funds from the university.