Acquisition of a Q-TOF Mass Spectrometer

购买 Q-TOF 质谱仪

基本信息

批准号：
8246986
负责人：
WEI LI
金额：
$ 32.5万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2013-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This application requests funding to acquire a Q-TOF mass spectrometer to replace the mass spectrometer component of an 18-year-old Bruker Esquire-LC/MS system, which is an essential part of the Shared Instrument Facility in the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center (UTHSC). The Bruker Esquire-LC/MS system has been well maintained and is the work horse supporting extensive small-molecular drug discovery and drug delivery programs at UTHSC in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection, and inflammation diseases. Several small-molecule drug candidates have been licensed for commercial development, including one currently in Phase III clinical trials. However, the age of the current mass spectrometer has resulted in more and more frequent breakdowns in recent years. Bruker officially stopped technical support for this type of instrument system in early 2010. Repair parts are scarce and have become very expensive. The proposed new Q-TOF mass spectrometer will replace the now unreliable mass spectrometer component of the Bruker Esquire-LC/MS system. This powerful new mass spectrometer will benefit more than 10 principal investigators supported by nine R01s, one RC2, one R33, three R21s, and other sources of support. The Q-TOF mass spectrometer will provide years of reliable accessibility, greater sensitivity in both MS and MS/MS modes, and the capability to obtain accurate mass for more efficient structure elucidation. This state-of-the-art instrument wil support drug discovery in preclinical development by using novel small molecules and their translation to innovative therapies for a variety of diseases. UTHSC is strongly committed to supporting biomedical research. The College of Pharmacy will provide $25,000 as a cost share for the purchase of the new instrument, fully support a staff scientist to maintain the Shared Instrument Facility, and assume all future maintenance and repair cost after the warranty period without charging user fees. An advisory committee will ensure effective utilization of the instrument and adequate access by the major users, other NIH-supported investigators, new investigators, and investigators with early-stage projects. PUBLIC HEALTH RELEVANCE: The Q-TOF mass spectrometer requested will replace a technologically limited Esquire-LC/MS mass spectrometer that is nearly two decades old and will provide reliable and sophisticated support for 20 currently funded projects important to human health. These projects focus on small-molecule drug discovery and drug delivery in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection and inflammation diseases.

描述（由申请人提供）：本申请要求资金购买Q-TOF质谱仪，以取代18岁的Bruker Esquire-LC/MS系统的质谱仪组件，这是田纳西大学健康科学科学中心（UTHSC）的药学系共享仪器设施的重要组成部分。 Bruker Esquire-LC/MS系统已得到很好的维护，是在UTHSC上支持广泛的小分子药物发现和药物输送计划的工作马，癌症，肥胖，糖尿病，放射保护，缓解放射，减轻放射，细菌拐点变化和炎症疾病。几名小分子候选药物已获得商业开发的许可，其中包括目前正在III期临床试验中的一项。但是，近年来，当前质谱仪的年龄导致越来越频繁的崩溃。布鲁克（Bruker）在2010年初正式停止了这类仪器系统的技术支持。维修零件很少，而且变得非常昂贵。提出的新Q-TOF质谱仪将取代Bruker Esquire-LC/MS系统的现在不可靠的质谱仪组件。这项强大的新质谱仪将使10位以上的主要研究人员受益，其中9个R01，1个RC2，1 R33，3个R21和其他支持来源。 Q-TOF质谱仪将提供多年可靠的可访问性，在MS和MS/MS模式中更高的灵敏度以及获得准确质量以进行更有效的结构阐明的能力。这种最先进的仪器将通过使用新型的小分子及其转化为各种疾病的创新疗法来支持临床前发育中的药物发现。 UTHSC强烈致力于支持生物医学研究。药学院将提供25,000美元作为购买新工具的成本份额，完全支持员工科学家维护共享工具设施，并在保修期后承担所有将来的维护和维修费用，而无需向用户费用收取费用。咨询委员会将确保有效利用该工具，并确保主要用户，其他NIH支持的研究人员，新的调查人员以及具有早期项目的调查人员的充分访问权限。公共卫生相关性：所需的Q-TOF质谱仪将取代技术有限的Esquire-LC/MS质谱仪，该质谱仪已有近二十年的历史，并将为目前对人类健康重要的20个目前资助的项目提供可靠且复杂的支持。这些项目着重于癌症，肥胖，糖尿病，辐射保护，缓解辐射，细菌拐点和炎症疾病的小分子药物发现和药物递送。