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Acquisition of a Q-TOF Mass Spectrometer

购买 Q-TOF 质谱仪

基本信息

批准号：
8246986
负责人：
WEI LI
金额：
$ 32.5万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2013-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This application requests funding to acquire a Q-TOF mass spectrometer to replace the mass spectrometer component of an 18-year-old Bruker Esquire-LC/MS system, which is an essential part of the Shared Instrument Facility in the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center (UTHSC). The Bruker Esquire-LC/MS system has been well maintained and is the work horse supporting extensive small-molecular drug discovery and drug delivery programs at UTHSC in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection, and inflammation diseases. Several small-molecule drug candidates have been licensed for commercial development, including one currently in Phase III clinical trials. However, the age of the current mass spectrometer has resulted in more and more frequent breakdowns in recent years. Bruker officially stopped technical support for this type of instrument system in early 2010. Repair parts are scarce and have become very expensive. The proposed new Q-TOF mass spectrometer will replace the now unreliable mass spectrometer component of the Bruker Esquire-LC/MS system. This powerful new mass spectrometer will benefit more than 10 principal investigators supported by nine R01s, one RC2, one R33, three R21s, and other sources of support. The Q-TOF mass spectrometer will provide years of reliable accessibility, greater sensitivity in both MS and MS/MS modes, and the capability to obtain accurate mass for more efficient structure elucidation. This state-of-the-art instrument wil support drug discovery in preclinical development by using novel small molecules and their translation to innovative therapies for a variety of diseases. UTHSC is strongly committed to supporting biomedical research. The College of Pharmacy will provide $25,000 as a cost share for the purchase of the new instrument, fully support a staff scientist to maintain the Shared Instrument Facility, and assume all future maintenance and repair cost after the warranty period without charging user fees. An advisory committee will ensure effective utilization of the instrument and adequate access by the major users, other NIH-supported investigators, new investigators, and investigators with early-stage projects. PUBLIC HEALTH RELEVANCE: The Q-TOF mass spectrometer requested will replace a technologically limited Esquire-LC/MS mass spectrometer that is nearly two decades old and will provide reliable and sophisticated support for 20 currently funded projects important to human health. These projects focus on small-molecule drug discovery and drug delivery in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection and inflammation diseases.

描述（由申请人提供）：本申请申请要求获得资金，以购买Q-TOF质谱仪，以取代已有18年历史的Bruker Esquire-LC/MS系统的质谱仪组件，该系统是田纳西大学健康科学中心（UTHSC）药物科学系共享仪器设施的重要组成部分。布鲁克Esquire-LC/MS系统得到了良好的维护，是支持UTHSC在癌症、肥胖、糖尿病、辐射防护、辐射缓解、细菌感染和炎症疾病领域广泛的小分子药物发现和药物递送计划的主力。几种小分子候选药物已获得商业开发许可，其中一种目前正在进行III期临床试验。然而，当前质谱仪的年龄导致近年来故障越来越频繁。布鲁克于2010年初正式停止了对此类仪器系统的技术支持。维修零件很少，而且变得非常昂贵。拟议的新型Q-TOF质谱仪将取代布鲁克Esquire-LC/MS系统中目前不可靠的质谱仪组件。这款功能强大的新型质谱仪将使10多名主要研究人员受益，并得到9台R 01、1台RC 2、1台R33、3台R21和其他支持来源的支持。Q-TOF质谱仪将提供多年可靠的可访问性，MS和MS/MS模式的更高灵敏度，以及获得准确质量以更有效地进行结构解析的能力。这种最先进的仪器将通过使用新型小分子及其转化为各种疾病的创新疗法来支持临床前开发中的药物发现。UTHSC坚定地致力于支持生物医学研究。药学院将提供25，000美元作为购买新仪器的费用分摊，全力支持一名工作人员科学家维护共享仪器设施，并承担保修期后的所有未来维护和维修费用，而不收取用户费用。一个咨询委员会将确保有效利用该工具，并确保主要用户、其他NIH支持的研究人员、新研究人员和早期项目的研究人员能够充分使用该工具。公共卫生相关性：所要求的Q-TOF质谱仪将取代使用了近20年的技术有限的Esquire-LC/MS质谱仪，并将为目前资助的20个对人类健康至关重要的项目提供可靠和先进的支持。这些项目专注于癌症、肥胖症、糖尿病、辐射防护、辐射缓解、细菌感染和炎症疾病领域的小分子药物发现和药物输送。