High Performance Digital NMR Spectrometer Console

高性能数字核磁共振波谱仪控制台

• 批准号: 7793710
• 负责人: PETER Edwin WRIGHT
• 金额: $ 42.43万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793710
• 关键词: Address; Amyloidosis; Arts; Biomolecular Nuclear Magnetic Resonance; Communicable Diseases; Disease; Electronics; Funding; Future; Generations; Health; Human; Investments; Malignant Neoplasms; Minor; Molecular; Myotonic Dystrophy; Nerve Degeneration; Performance; Phase; Physiologic pulse; Relaxation; Request for Proposals; Research; Research Institute; Sampling; United States; base; cryogenics; digital; improved; instrument; instrumentation; programs; radiofrequency; research study; structural biology

DESCRIPTION (provided by applicant): The Biomolecular NMR facility at The Scripps Research Institute is one of the foremost in the United States. Scripps has made an extraordinary investment over the past two decades in building and equipping this facility but the electronics consoles on many of the spectrometers are now obsolete and need to be replaced. This proposal requests funding to replace the obsolete 1997-vintage DRX console on our most sensitive instrument, an 800 MHz spectrometer equipped with a cryogenic probe, with a state-of- the-art Avance III console. The new electronics console is expected to increase the sensitivity of the instrument by as much as 25%, provide enhanced radiofrequency generation and phase stability to improve the performance of demanding pulse experiments, and enable the implementation of new 2H relaxation and non-linear sampling experiments that simply cannot be performed with our existing instrumentation. The upgraded electronics will directly benefit the NIH-funded research programs of four major user groups (Dyson, Williamson, Wright, and W|thrich) and two minor users (Kelly and Otomo). These research programs are probing fundamental questions in structural biology and are addressing key issues related to human health and disease. The enhanced capabilities of the instrument will facilitate ongoing and future research on the underlying molecular basis of cancer, myotonic dystrophy, neurodegeneration, amyloid diseases, and infectious disease.

描述(申请人提供)：斯克里普斯研究所的生物分子核磁共振设备是美国最先进的设备之一。在过去的20年里，斯克里普斯在建造和装备这个设施方面做出了巨大的投资，但许多光谱仪上的电子控制台现在已经过时，需要更换。这项提案要求提供资金，将我们最灵敏的仪器上陈旧的1997年老式DRX控制台-配备低温探头的800 MHz光谱仪-替换为最先进的Avance III控制台。新的电子控制台预计将使仪器的灵敏度提高25%，提供增强的射频产生和相位稳定性，以改善要求苛刻的脉冲实验的性能，并能够实施新的2H弛豫和非线性采样实验，这些实验根本无法使用我们现有的仪器进行。升级后的电子产品将直接惠及NIH资助的四个主要用户群体(戴森、威廉姆森、赖特和W|thrich)和两个次要用户(Kelly和Otomo)的研究项目。这些研究计划正在探索结构生物学的基本问题，并解决与人类健康和疾病有关的关键问题。该仪器的增强能力将促进目前和未来对癌症、强直性肌营养不良、神经退行性变、淀粉样蛋白疾病和传染病的潜在分子基础的研究。