High Performance Digital NMR Spectrometer Console

高性能数字核磁共振波谱仪控制台

• 批准号: 7793710
• 负责人: PETER Edwin WRIGHT
• 金额: $ 42.43万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793710
• 关键词: Address; Amyloidosis; Arts; Biomolecular Nuclear Magnetic Resonance; Communicable Diseases; Disease; Electronics; Funding; Future; Generations; Health; Human; Investments; Malignant Neoplasms; Minor; Molecular; Myotonic Dystrophy; Nerve Degeneration; Performance; Phase; Physiologic pulse; Relaxation; Request for Proposals; Research; Research Institute; Sampling; United States; base; cryogenics; digital; improved; instrument; instrumentation; programs; radiofrequency; research study; structural biology

DESCRIPTION (provided by applicant): The Biomolecular NMR facility at The Scripps Research Institute is one of the foremost in the United States. Scripps has made an extraordinary investment over the past two decades in building and equipping this facility but the electronics consoles on many of the spectrometers are now obsolete and need to be replaced. This proposal requests funding to replace the obsolete 1997-vintage DRX console on our most sensitive instrument, an 800 MHz spectrometer equipped with a cryogenic probe, with a state-of- the-art Avance III console. The new electronics console is expected to increase the sensitivity of the instrument by as much as 25%, provide enhanced radiofrequency generation and phase stability to improve the performance of demanding pulse experiments, and enable the implementation of new 2H relaxation and non-linear sampling experiments that simply cannot be performed with our existing instrumentation. The upgraded electronics will directly benefit the NIH-funded research programs of four major user groups (Dyson, Williamson, Wright, and W|thrich) and two minor users (Kelly and Otomo). These research programs are probing fundamental questions in structural biology and are addressing key issues related to human health and disease. The enhanced capabilities of the instrument will facilitate ongoing and future research on the underlying molecular basis of cancer, myotonic dystrophy, neurodegeneration, amyloid diseases, and infectious disease.

描述（由申请人提供）：斯克里普斯研究所的生物分子核磁共振设备是美国最重要的设备之一。在过去的二十年里，斯克里普斯在建造和装备这一设施方面进行了非凡的投资，但许多光谱仪上的电子控制台现在已经过时，需要更换。该提案要求拨款用最先进的Avance III控制台取代我们最灵敏仪器上过时的1997年老式DRX控制台，该仪器是一台配备低温探头的800 MHz光谱仪。新的电子控制台预计将仪器的灵敏度提高多达25%，提供增强的射频产生和相位稳定性，以提高要求苛刻的脉冲实验的性能，并能够实现新的2H松弛和非线性采样实验，这些实验根本无法用我们现有的仪器进行。升级后的电子设备将直接受益于美国国立卫生研究院资助的四个主要用户组（戴森、威廉森、赖特和W bbbb3）和两个次要用户组（凯利和Otomo）的研究项目。这些研究项目正在探索结构生物学的基本问题，并解决与人类健康和疾病相关的关键问题。该仪器的增强功能将促进正在进行和未来对癌症、肌强直性营养不良、神经变性、淀粉样蛋白疾病和传染病的潜在分子基础的研究。