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A PROBE STUDY OF THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF A THREE-DOSE

A PROBE STUDY OF THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF A THREE-DOSE
三剂安全性、耐受性和免疫原性的探索研究
批准号：
7605532
负责人：
PETER Edwin WRIGHT
金额：
$0.3万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-12-01 至 2007-09-16
来源：
https://reporter.nih.gov/project-details/7605532
关键词：
Biological AssayComputer Retrieval of Information on Scientific Projects DatabaseDoseExhibitsFundingGaggingGrantHIV-1Immune responseInstitutionPlacebosResearchResearch PersonnelResourcesSafetySourceUnited States National Institutes of HealthVaccinationVaccinesWeekbaseenzyme linked immunospot assayimmunogenicity

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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (1) Intramuscluar prime boost vaccination with the Ad5 HIV-1 gag vaccine will be generally safe and well-tolerated. (2) Four weeks after the boost vaccination with the Ad5 HIV-1 gag vaccine, at least one of the four vaccine dose groups will exhibit an immune response that is better than the placebo, based on the unfractionated gag-specific IFN-y ELISPOT assay.
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