Pre-clinical PET Imaging System
临床前PET成像系统
基本信息
- 批准号:7793801
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-17 至 2011-06-16
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBiochemical ProcessCancer CenterChildCollaborationsCollectionComplexComprehensive Cancer CenterCustomCyclotronsDataDiscipline of Nuclear MedicineDiseaseDissectionDoseDrug KineticsEnvironmentFacultyFunctional disorderFundingGrantHospitalsHourImageImaging TechniquesInstitutionInvestmentsLocationMeasurementMedical ImagingMethodsModelingPediatric OncologyPharmaceutical ChemistryPharmaceutical PreparationsPositron-Emission TomographyPre-Clinical ModelProcessRadiochemistryRadiopharmaceuticalsRegimenRegulationResearchResearch PersonnelResourcesStimulusSystemTechnologyTestingTherapeuticTimeTitrationsTransgenic ModelTransgenic OrganismsTranslational ResearchUnited States National Institutes of HealthXenograft ModelXenograft procedureanimal breedingcellular oncologycostdesignin vivomolecular imagingnovelnovel therapeuticspre-clinicalpreclinical studyprogramspublic health relevanceradiotracerresponsetumor
项目摘要
DESCRIPTION (provided by applicant): With the recent addition of a cyclotron and radiochemistry facility to our Nuclear Medicine Division, St Jude Children's Research Hospital investigators now have access to a wide variety of both known and novel radiotracers for positron emission tomography (PET) imaging. The small animal PET scanner that is the subject of this application is requested to expand the capabilities of our existing Animal Imaging Center (AIC) to take full advantage of this newly acquired access to PET radiotracers. We are currently engaged in several collaborative projects using PET radiotracers for preclinical studies. These studies, while very powerful and quantitative, are limited in that without a small animal PET scanner, they require sacrifice and dissection of the subject animals and yield data at only discrete time points. The real strength of PET lies in the ability to make such quantitative measurements of in vivo biochemical processes in real time. Furthermore, the ability to make repeated measurements in the same animal over hours, days or weeks allows assessment of longitudinal parameters such as therapy response, subject-specific titration of drug doses and regulation of biochemical processes in response to stimuli. Similarly, new therapeutic discovery would benefit from the in vivo pharmacokinetic studies possible in real time with small animal PET using custom designed radiotracers. All of these latter studies are much more complex and expensive, or simply impossible, using dissection methods rather than in vivo imaging. In addition, our institution has a diverse collection of unique preclinical models (both transgenic and xenograft) with which to study disease processes and test new therapeutic regimens in pediatric oncology. All of these models could greatly benefit from the unique capabilities of PET imaging to enhance current research efforts. Dissection studies that assess tumor pathophysiology (as we do now) are challenging in orthotopic xenograft models where exact tumor location is less predictable. Furthermore, non-terminal imaging is the only practical method for studies of transgenic models due to the cost and difficulty of animal breeding. The AIC serves as a core resource to all St Jude investigators and is funded in part by our NCI Comprehensive Cancer Center grant. We have identified 12 faculty investigators who would be the primary users of this core technology, most of whom have funded research efforts on one or multiple NIH grants and are engaged in multi-disciplinary collaborative projects with one or more investigators at St Jude and at other institutions. They represent 6 academic departments and 4 Cancer Center Programs with a variety of expertise in imaging, molecular and cellular oncology, pharmacokinetics, therapeutic design and medicinal chemistry. The addition of a small animal PET scanner will allow us to fully capture this environment of collaboration and the institution's investment in Nuclear Medicine research and will facilitate St Jude's commitment to outstanding translational research.
PUBLIC HEALTH RELEVANCE: St Jude Children's Research Hospital is dedicated to the study and treatment of catastrophic disease in children. With the recent addition of a cyclotron and radiochemistry facility to our Nuclear Medicine Division, St Jude Children's Research Hospital investigators now have access to a variety of novel radioactive drugs for a medical imaging procedure called positron emission
tomography. The addition of a preclinical PET imaging camera will allow us to take full advantage of both this recent investment in Nuclear Medicine research and the existing variety of preclinical models unique to our institution, thus facilitating St Jude's commitment to outstanding translational research.
描述(由申请人提供):随着我们核医学部门最近增加的回旋加速器和放射化学设备,圣犹达儿童研究医院的研究人员现在可以使用各种已知和新型的放射性示踪剂进行正电子发射断层扫描(PET)成像。小型动物PET扫描仪是本应用程序的主题,要求扩展我们现有的动物成像中心(AIC)的能力,以充分利用这一新获得的PET放射性示踪剂。我们目前正在进行几个合作项目,使用PET放射性示踪剂进行临床前研究。这些研究,虽然非常强大和定量,但由于没有小型动物PET扫描仪,它们需要牺牲和解剖实验动物,并且只能在离散的时间点获得数据,因此受到限制。PET的真正优势在于能够实时对体内生化过程进行定量测量。此外,在同一只动物身上进行数小时、数天或数周重复测量的能力,可以评估纵向参数,如治疗反应、特定受试者的药物剂量滴定和对刺激反应的生化过程调节。同样,新的治疗发现将受益于使用定制设计的放射性示踪剂的小动物PET实时体内药代动力学研究。所有这些后一种研究都更加复杂和昂贵,或者根本不可能使用解剖方法而不是体内成像。此外,我们的机构还拥有多种独特的临床前模型(包括转基因和异种移植),用于研究儿童肿瘤的疾病过程和测试新的治疗方案。所有这些模型都可以极大地受益于PET成像的独特功能,以加强当前的研究工作。评估肿瘤病理生理的解剖研究(正如我们现在所做的)在原位异种移植模型中具有挑战性,因为肿瘤的确切位置难以预测。此外,由于动物育种的成本和难度,非末端成像是唯一可行的转基因模型研究方法。AIC是所有圣犹达研究人员的核心资源,部分由NCI综合癌症中心资助。我们已经确定了12名教师调查员,他们将是这项核心技术的主要用户,他们中的大多数人已经在一项或多项NIH拨款中资助了研究工作,并与圣犹达和其他机构的一名或多名调查员参与了多学科合作项目。他们代表了6个学术部门和4个癌症中心项目,在成像、分子和细胞肿瘤学、药代动力学、治疗设计和药物化学方面具有各种专业知识。增加一台小型动物PET扫描仪将使我们能够充分捕捉这种合作环境和该机构在核医学研究方面的投资,并将促进圣犹达对杰出转化研究的承诺。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SCOTT E SNYDER其他文献
SCOTT E SNYDER的其他文献
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- 批准号:
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- 资助金额:
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C11 ACETATE PET IMAGING OF PROSTATE AND RENAL CANCER
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6514857 - 财政年份:2001
- 资助金额:
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前列腺癌和肾癌的 C11 醋酸盐 PET 成像
- 批准号:
6633914 - 财政年份:2001
- 资助金额:
$ 50万 - 项目类别:
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