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Carl Zeiss AxioImager Z1 Research Microscope

卡尔蔡司 AxioImager Z1 研究显微镜

基本信息

批准号：
7794149
负责人：
Mary E Blue
金额：
$ 13.85万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-15 至 2011-06-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): We are applying for funds to purchase an AxioImager Z1 research microscope from Carl Zeiss to replace our Zeiss fluorescence Axioplan microscope, which has been heavily used for the past fifteen or so years by a large number of users, that is showing considerable wear and tear, and for which replacement parts and lenses are no longer available. The proposed microscope will be used by a group of 8 users who are all faculty within the Hugo W. Moser Research Institute at Kennedy Krieger, each with faculty appointments at the Johns Hopkins University School of Medicine. The purchase of this microscope will support these investigators' R01, P01, K awards and nonfederal grants and will be crucial for the continued research progress and productivity of these grants. The projects that will utilize the proposed microscope are broad in scope, ranging from animal models for neonatal hypoxic ischemia, Sturge Weber Syndrome and other developmental disorders, such as Rett Syndrome, autism, adrenoleucodystrophy and other metabolic disorders, to brain cancer. The projects require sophisticated and high resolution optics and image analysis that the proposed microscope and accompanying software will provide. Award of this instrument will have a positive impact on the productivity of the projects. The microscope will be housed within a Histology and Imaging Core that is funded by an Intellectual and Developmental Disabilities Resource Center (IDDRC) (formerly MRDDRC) at Kennedy Krieger Institute, and provides support for training and maintenance for the microscopes within it. This will enhance the productivity of the undergraduate and graduate students, postdoctoral fellows, staff and faculty that utilize this IDDRC Core. In turn, this will advance the mission of the Kennedy Krieger Institute, which is to understand the biological basis for developmental disabilities, and to discover new treatments for enhancing the lives and potential of the children who are treated here.

描述（由申请人提供）：我们正在申请资金，从卡尔蔡司购买AxioImager Z1研究显微镜，以取代我们的蔡司荧光Axioplan显微镜，该显微镜在过去15年左右的时间里被大量用户大量使用，显示出相当大的磨损，并且不再提供更换部件和镜头。建议的显微镜将由8名用户使用，他们都是Hugo W.肯尼迪克里格的莫泽研究所，每个都在约翰霍普金斯大学医学院任教。购买这台显微镜将支持这些研究人员的R01，P01，K奖和非联邦赠款，并将对这些赠款的持续研究进展和生产力至关重要。使用拟议显微镜的项目范围广泛，从新生儿缺氧缺血、斯特奇韦伯综合症和其他发育障碍（例如雷特综合症、自闭症、肾上腺白质营养不良和其他代谢障碍）的动物模型到脑癌。该项目需要先进的和高分辨率的光学和图像分析，拟议的显微镜和配套软件将提供。授予这一工具将对项目的生产力产生积极影响。该显微镜将被安置在由肯尼迪克里格研究所的智力和发育障碍资源中心（IDDRC）（前身为MRDDRC）资助的组织学和成像核心中，并为其中的显微镜提供培训和维护支持。这将提高使用该IDDRC核心的本科生和研究生，博士后研究员，工作人员和教师的生产力。反过来，这将推进肯尼迪克里格研究所的使命，即了解发育障碍的生物学基础，并发现新的治疗方法，以提高在这里接受治疗的儿童的生活和潜力。