Atomic Force Microscope

描述(由申请人提供)：为在弗吉尼亚大学建立原子力显微镜的生物医学应用核心实验室，需要购买原子力显微镜(AFM)的资金。购买的仪器将是来自加利福尼亚州圣巴巴拉的Veeco计量公司的带有纳米V扫描显微镜的多模V扫描探针显微镜和V SPM控制站。将购买配件，以便在生理缓冲和温度条件下对生物样本进行成像。核心实验室将设在医学院的中心位置，将由医学院生物化学和分子遗传学、药理学、分子生理学和生物物理、微生物学和医学系以及文理学院化学和生物系的研究人员使用。主要的共同研究主题将涉及模型膜系统中或模型膜系统上的信号过程以及大分子复合体的动力学和结构。用这台仪器研究的过程是癌症、内分泌紊乱、神经病理学、细菌感染和生长发育的分子基础的基础。核心实验室将由一名经验丰富的AFM研究人员和一个跨部门咨询委员会领导，并将提供培训和外联活动，以加强AFM在NIH资助的大学生物医学研究项目中的利用。

DESCRIPTION (provided by applicant): Funds are requested to purchase an atomic force microscope (AFM) in order to establish the Core Laboratory for Biomedical Applications of Atomic Force Microscopy at the University of Virginia. The instrument purchased will be the Multimode V Scanning Probe Microscope with Nanoscope V SPM Control Station from Veeco Metrology, Inc., in Santa Barbara, CA. Accessories will be purchased to allow imaging of biological samples under physiological buffer and temperature conditions. The Core Laboratory will be centrally located in the School of Medicine and will be used by researchers from the Departments of Biochemistry and Molecular Genetics, Pharmacology, Molecular Physiology and Biological Physics, Microbiology, and Medicine in the School of Medicine, and from the Departments of Chemistry and Biology in the College of Arts and Sciences. The major common research themes will involve signaling processes in or on model membrane systems and the dynamics and structure of macromolecular complexes. The processes that will be studied with this instrument are fundamental to the molecular basis of cancer, endocrine disorders, neuropathology, bacterial infection, and growth and development. The Core Laboratory will be directed by an experienced AFM researcher and an interdepartmental advisory committee, and will provide training and outreach activities to enhance the utilization of the AFM in NIH-funded biomedical research programs at the University.