Atomic Force Microscope

描述（由申请人提供）：资金要求购买原子力显微镜（AFM），以建立原子力显微镜在弗吉尼亚大学的生物医学应用的核心实验室。购买的仪器将是Veeco Metrology，Inc.的Multimode V扫描探针显微镜，配有Nanoscope V SPM控制站，在加利福尼亚州的圣巴巴拉。将购买附件，以允许在生理缓冲液和温度条件下对生物样本进行成像。核心实验室将位于医学院的中心，并将由医学院生物化学和分子遗传学，药理学，分子生理学和生物物理学，微生物学和医学系的研究人员以及艺术和科学学院的化学和生物学系的研究人员使用。主要的共同研究主题将涉及模型膜系统中或模型膜系统上的信号传导过程以及大分子复合物的动力学和结构。将使用该仪器研究的过程对于癌症、内分泌紊乱、神经病理学、细菌感染以及生长和发育的分子基础至关重要。核心实验室将由经验丰富的AFM研究人员和跨部门咨询委员会指导，并将提供培训和推广活动，以提高AFM在NIH资助的生物医学研究项目中的利用率。

DESCRIPTION (provided by applicant): Funds are requested to purchase an atomic force microscope (AFM) in order to establish the Core Laboratory for Biomedical Applications of Atomic Force Microscopy at the University of Virginia. The instrument purchased will be the Multimode V Scanning Probe Microscope with Nanoscope V SPM Control Station from Veeco Metrology, Inc., in Santa Barbara, CA. Accessories will be purchased to allow imaging of biological samples under physiological buffer and temperature conditions. The Core Laboratory will be centrally located in the School of Medicine and will be used by researchers from the Departments of Biochemistry and Molecular Genetics, Pharmacology, Molecular Physiology and Biological Physics, Microbiology, and Medicine in the School of Medicine, and from the Departments of Chemistry and Biology in the College of Arts and Sciences. The major common research themes will involve signaling processes in or on model membrane systems and the dynamics and structure of macromolecular complexes. The processes that will be studied with this instrument are fundamental to the molecular basis of cancer, endocrine disorders, neuropathology, bacterial infection, and growth and development. The Core Laboratory will be directed by an experienced AFM researcher and an interdepartmental advisory committee, and will provide training and outreach activities to enhance the utilization of the AFM in NIH-funded biomedical research programs at the University.