Acquisition of an Illumina Genome Analyzer for The Research Institute

描述(由申请人提供)： 下一代测序技术使基因组学研究发生了革命性的变化。它在了解人类健康和疾病方面具有巨大的潜力。在国家儿童医院研究所购买下一代测序仪对于履行我们根据最高科学和道德标准从事高质量、尖端研究以增强儿童健康的承诺至关重要。在这份提案中，我们申请资金购买Illumina基因组分析仪IIx。我们有效地展示了来自我们的六个重点研究中心的12名由NIH资助的生物医学研究人员如何在他们的高影响力研究中利用现场下一代测序仪。随着我们的研究项目继续扩大，我们预计对这项技术的需求将会增长。该仪器的使用和生物医学基因组学核心的拟议支持将对年轻的研究人员、博士后研究科学家、内科科学家和临床研究员特别有帮助。鉴于这项技术将对我们的研究产生影响，研究所承诺提供超过25万美元，以确保该技术得到迅速部署和全面支持。此外，研究所致力于为这项技术和运行这项技术的人员提供长期的财政支持。收购这一仪器将使我们能够继续扩大我们在战略重点领域的计划，即围产期研究、传染病研究、儿童先天性和获得性心脏疾病、消化系统疾病和儿童癌症。作为全国排名前十的独立儿童医院研究所之一，我们的研究已经证明，它对健康有很强的影响。Illumina Genome Analyzer IIx系统将为我们的研究机构带来最先进的基因组学能力，并将极大地提高我们进行与儿科健康和疾病相关的基因组学研究的能力。

DESCRIPTION (provided by applicant): Next-generation sequencing technology has revolutionized genomics research. It has tremendous potential for understanding human health and disease. The acquisition of a next-generation sequencer at The Research Institute at Nationwide Children's Hospital is essential to meet our commitment to enhance the health of children by engaging in high quality, cutting-edge research according to the highest scientific and ethical standards. In this proposal, we apply for funding to acquire an Illumina Genome Analyzer IIx. We effectively demonstrate how twelve NIH-funded biomedical research investigators from six of our Research Centers of Emphasis can utilize an on-site next-generation sequencer in their high-impact research. As our research program continues to expand, we anticipate that the demand for this technology will grow. Access to this instrument and the proposed support from the Biomedical Genomics Core will be particularly helpful for young investigators, postdoctoral research scientists, physician scientists and clinical fellows. In light of the impact that this technology will have on our research, The Research Institute is committing over $250,000 to ensure that the technology is rapidly deployed and fully supported. Furthermore, The Research Institute is committed to providing the long-term financial support for this technology and the staff required run it. Acquisition of this instrument will allow us to continue expanding our programs in areas of strategic emphasis, namely perinatal research, infectious diseases research, congenital and acquired disorders of the heart in children, digestive diseases and childhood cancer. Being one of the top 10 independent Children's Hospital Research Institutes in the country, our research has already demonstrated that it has a strong impact with relevance to health. The Illumina Genome Analyzer IIx System will bring the most technologically advanced genomics capabilities to our research institute and will immeasurably improve our ability to conduct genomics research relevant to pediatric health and disease.