Effect of Biomechanical Force Exposure on Cognition and Brain Activation in TBI

生物力学力暴露对 TBI 认知和大脑激活的影响

• 批准号: 8090299
• 负责人: Thomas McAllister
• 金额: $ 42.05万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8090299
• 关键词: Acceleration; Acute; Attention; Biomechanics; Brain; Brain Concussion; Brain imaging; Cerebrum; Characteristics; Clinical; Clinical Management; Cognition; Cognitive; Coupled; Data; Development; Exposure to; Frequencies; Functional Magnetic Resonance Imaging; Genetic; Guidelines; Head; Helmet; Hockey; Individual; Injury; Lead; Learning; Location; Long-Term Effects; Manufactured football; Measures; Minor Head Injury; Monitor; Motor; Outcome; Parietal Lobe; Pathway interactions; Pattern; Play; Reaction Time; Recording of previous events; Risk; Seasons; Short-Term Memory; Speed; Sports; Students; Testing; Time; Traumatic Brain Injury; base; clinical Diagnosis; cognitive function; evidence base; frontal lobe; information processing; interest

DESCRIPTION (provided by applicant): 300,000 individuals sustain sports concussions each year in the U.S. The short and long-term effects of sports concussions and sub-concussive impacts are not known, nor are the cumulative effects of repeated injuries understood. What is clear is that there is enormous variability in outcome, although the reasons for this variability are not understood. The overarching theme of this proposal is that an individual's exposure to biomechanical forces is a critical factor influencing outcome. This has two broad components: the characteristics of a single impact (e.g. linear acceleration, rotational acceleration, direction etc.), and the history of exposure to biomechanical forces (e.g. measures of frequency and intensity of impacts over the preceding days and weeks). We propose to use technological advances in on-field head impact monitoring, cognitive testing, and functional brain imaging to learn for the first time what types of head impacts, under what circumstances, in which individuals, cause what effects in brain function. Both acute (post-concussive) and cumulative (pre to one-month post season) monitoring of biomechanical forces are of interest and will be assessed. Three groups of student athletes (football/hockey players with concussion, teammates without concussion, matched non-impact sport athletes) will be studied at three time points (preseason, postseason, and within one week of a concussion) using a standardized cognitive battery and functional MRI (fMRI). Impact parameters will be directly measured using helmet-based accelerometer units. Results of this study should yield important information on the biomechanics and genetics of sports-related traumatic brain injury, lead to more informed return-to-play guidelines, and provide objective information regarding the effects of cumulative minor head injuries.

描述（由申请人提供）：在美国，每年有30万人遭受运动性脑震荡。运动性脑震荡和亚脑震荡影响的短期和长期影响尚不清楚，重复性损伤的累积影响也不清楚。很清楚的是，结果存在巨大的差异，尽管这种差异的原因尚不清楚。该提案的总体主题是，个人暴露于生物力学力量是影响结果的关键因素。这有两个广泛的组成部分：一个单一的影响的特点（如线性加速度，旋转加速度，方向等），以及暴露于生物力学力的历史（例如，测量前几天和前几周内撞击的频率和强度）。我们建议利用现场头部撞击监测、认知测试和功能性脑成像方面的技术进步，首次了解什么类型的头部撞击、在什么情况下、在哪些个体中会对大脑功能产生什么影响。生物力学力的急性（脑震荡后）和累积（赛季前至赛季后一个月）监测都是值得关注的，并将进行评估。三组学生运动员（有脑震荡的足球/曲棍球运动员，没有脑震荡的队友，匹配的非冲击运动员）将在三个时间点（季前赛，季后赛和脑震荡一周内）使用标准化认知电池和功能性MRI（fMRI）进行研究。将使用头盔加速度计直接测量撞击参数。这项研究的结果应该产生重要的信息，运动相关的创伤性脑损伤的生物力学和遗传学，导致更明智的返回到发挥的指导方针，并提供有关累积轻微头部损伤的影响的客观信息。