NMARC Pilot Project Core C6

NMARC 试点项目核心 C6

• 批准号: 10674489
• 负责人: Carlos Fernando Valenzuela
• 金额: $ 13.64万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674489
• 关键词: Advisory Committees; Alcohols; Applications Grants; Area; Astrocytes; Award; Behavioral; Cell physiology; Cells; Clinical; Communities; Complement; Data; Development; Diagnosis; Doctor of Philosophy; Ethanol; Extramural Activities; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fostering; Foundations; Functional disorder; Funding; Goals; Grant; Growth; Head; Institution; Intervention; Mentors; Mind; Monitor; Mus; Neurosciences; New Mexico; Oligodendroglia; Paper; Peer Review; Phase; Pilot Projects; Play; Positioning Attribute; Preparation; Publishing; Research; Research Activity; Research Assistant; Research Personnel; Research Project Grants; Research Support; Resources; Role; Testing; alcohol research; angiogenesis; applied behavior analysis; circular RNA; fetal; forging; in vivo; member; novel strategies; pain processing; professor; programs; recruit; success

The overall goal of the Pilot Project Core of the New Mexico Alcohol Research Center (NMARC) is to foster cross-disciplinary FASD research across campus and promote growth of the Center. The Core will provide a critical opportunity to develop new basic, translational and clinical fetal alcohol research projects that complement and broaden the NMARC's research program portfolio. Selected projects must fit within the context of the Center's three strategic objectives as well as build on the overall integration and sustainability of the Center's research activities. Pilot projects will be funded for up to 2 years. The goal of each pilot project is to obtain sufficient preliminary data to develop competitive research grant applications and cultivate new investigators that will form part of the center. Support from the NMARC Pilot Project Core has played a crucial role in the success of R21 and/or R01 applications submitted by center investigators. Importantly, our Pilot Project Core has opened new and important research areas in the FASD field (e.g., impact of PAE on place cell, grid cell, and head direction cell function; effect of PAE on pain processing; interaction between placental dysfunction and PAE) and has brought novel approaches into the field (e.g., applied behavioral analysis in FASD management; circular RNA studies). The Core will primarily support new investigators that have yet to obtain substantial independent research support. A year prior to the end of the Pilot Projects that are initially funded, a call for additional Pilot Project proposals will be widely advertised within the scientific community at UNM, the Mind Research Network, and neighboring institutions. Each project will have an Advisory Team composed of senior alcohol researchers with complementary scientific expertise to that of the pilot project PI. The Center Director and NMARC Steering Committee will monitor progress of all pilot projects. Pilot project progress will be reviewed tri-annually by the NMARC Steering Committee and annually by the Program Advisory Committee. The Pilot Project Core goals have been successfully accomplished during the first 3½ years of the first five-year phase of the NMARC P50 award. We recruited several new investigators from diverse fields into the FASD research field. Two R21 and one R01 grants were obtained using preliminary data collected under the support of the Pilot Project Core. A total of 7 peer-reviewed papers have been published or submitted by Pilot Project Core investigators. Support was preferentially provided to junior faculty members. The Pilot Project Core will support two projects during the first two years. Project 6A will test the hypothesis that miR-150 inhibits Vezf1 to alter angiogenesis in the developing cortices of mice prenatally exposed to alcohol (P.I. Amy Gardiner, Ph.D., Research Assistant Professor, Dept of Neurosciences). Project 6B will investigate the effects of prenatal ethanol exposure on astrocyte and oligodendrocyte development in vivo (P.I. Tou Yia Vue, Ph.D., Assistant Professor, Dept of Neurosciences).

新墨西哥州酒精研究中心(NMARC)试点项目核心的总体目标是促进 在校园内进行跨学科的FASD研究，促进中心的发展。核心将提供一个 开发新的基础、翻译和临床胎儿酒精研究项目的关键机会 补充和扩大NMARC的研究项目组合。选定的项目必须适合 中心的三个战略目标的背景以及建立在全面一体化和可持续性的基础上 该中心的研究活动。试点项目将获得最长两年的资金支持。每个试点项目的目标是 获得足够的初步数据，以开发有竞争力的研究资助申请并培养新的 调查人员将成为该中心的一部分。来自NMARC试点项目核心的支持起到了至关重要的作用 在中心调查人员提交的R21和/或R01申请成功的过程中发挥的作用。重要的是，我们的飞行员 Project Core在FASD领域开辟了新的重要研究领域(例如，PAE对Place的影响 细胞、网格细胞和头部方向细胞功能；PAE在疼痛处理中的作用；胎盘之间的相互作用 功能障碍和PAE)，并将新方法引入该领域(例如，在 FASD管理；循环RNA研究)。核心将主要支持尚未完成调查的新调查人员 获得实质性的独立研究支持。在试点项目结束前一年，这些项目最初 在资助下，将在科学界广泛宣传额外的试点项目提案，网址为 UNM、心理研究网络和邻近机构。每个项目都将有一个顾问团队 由高级酒精研究人员组成，他们具有与试点项目PI互补的科学专业知识。 中心主任和NMARC指导委员会将监督所有试点项目的进展情况。试点项目 NMARC指导委员会将每三年审查一次进展情况，该计划每年审查一次 咨询委员会。试点项目核心目标在前三年半期间成功实现 NMARC P50奖项第一个五年阶段的年份。我们招募了几名新的调查员 不同领域进入FASD研究领域。两笔R21和一笔R01赠款通过初步的 在试点项目核心的支持下收集的数据。共有7篇同行评议的论文 由试点项目核心调查员发表或提交。优先向初级教职员工提供支持 会员。试点项目核心将在头两年支持两个项目。项目6A将测试 MiR-150抑制Vezf1改变小鼠出生前发育皮质血管生成的假说 酗酒(P.I.艾米·加德纳，博士，神经科学系研究助理教授)。项目 6B将研究孕期酒精暴露对小鼠星形胶质细胞和少突胶质细胞发育的影响 Vivo(P.I.Tou Yia Vue，博士，神经科学系助理教授)。