NMARC Pilot Project Core C6

新墨西哥州酒精研究中心（NMARC）核心试点项目的总体目标是促进 跨学科的FASD研究在整个校园，促进中心的发展。核心将提供一个 开发新的基础，转化和临床胎儿酒精研究项目的关键机会， 补充和扩大NMARC的研究项目组合。选定的项目必须符合 该中心的三个战略目标的背景下，以及建立在整体整合和可持续性， 中心的研究活动。试点项目将获得最多两年的资助。每个试点项目的目标是 获得足够的初步数据，以开发有竞争力的研究资助申请，并培养新的 调查人员将成为该中心的一部分。NMARC试点项目核心的支持发挥了关键作用， 在中心研究者提交的R21和/或R01申请成功中的作用。重要的是，飞行员 Project Core在FASD领域开辟了新的重要研究领域（例如，PAE对地方影响 细胞、网格细胞和头部方向细胞功能; PAE对疼痛处理的影响;胎盘与 功能障碍和PAE）并将新的方法引入该领域（例如，应用行为分析 FASD管理;环状RNA研究）。核心将主要支持新的调查人员， 获得大量独立研究支持。试点项目结束前一年， 获得资助后，将在科学界广泛宣传更多的试点项目提案， UNM，心灵研究网络，以及邻近的机构。每个项目将有一个顾问团队 由具有与试点项目PI互补的科学专门知识的高级酒精研究人员组成。 中心主任和NMARC指导委员会将监督所有试点项目的进展情况。试点项目 NMARC指导委员会每三年对进展情况进行一次审查，而该计划每年进行一次审查 咨询委员会。试点项目的核心目标已在前三年半成功完成 NMARC P50奖项的第一个五年阶段。我们招募了几名新的调查员， 不同的领域进入FASD研究领域。两个R21和一个R01赠款获得初步使用 在试点项目核心的支持下收集的数据。共有7篇同行评审论文 由试点项目核心研究者发表或提交。优先向初级教员提供支助 成员试点项目核心将在头两年支持两个项目。项目6A将测试 miR-150抑制Vezf1改变小鼠产前发育皮质血管生成的假设 暴露于酒精（P.I.艾米加德纳博士，研究助理教授，神经科学系）。项目 6B将研究产前乙醇暴露对星形胶质细胞和少突胶质细胞发育的影响， 体内（P.I. Yia Vue博士，神经科学系助理教授）。

The overall goal of the Pilot Project Core of the New Mexico Alcohol Research Center (NMARC) is to foster cross-disciplinary FASD research across campus and promote growth of the Center. The Core will provide a critical opportunity to develop new basic, translational and clinical fetal alcohol research projects that complement and broaden the NMARC's research program portfolio. Selected projects must fit within the context of the Center's three strategic objectives as well as build on the overall integration and sustainability of the Center's research activities. Pilot projects will be funded for up to 2 years. The goal of each pilot project is to obtain sufficient preliminary data to develop competitive research grant applications and cultivate new investigators that will form part of the center. Support from the NMARC Pilot Project Core has played a crucial role in the success of R21 and/or R01 applications submitted by center investigators. Importantly, our Pilot Project Core has opened new and important research areas in the FASD field (e.g., impact of PAE on place cell, grid cell, and head direction cell function; effect of PAE on pain processing; interaction between placental dysfunction and PAE) and has brought novel approaches into the field (e.g., applied behavioral analysis in FASD management; circular RNA studies). The Core will primarily support new investigators that have yet to obtain substantial independent research support. A year prior to the end of the Pilot Projects that are initially funded, a call for additional Pilot Project proposals will be widely advertised within the scientific community at UNM, the Mind Research Network, and neighboring institutions. Each project will have an Advisory Team composed of senior alcohol researchers with complementary scientific expertise to that of the pilot project PI. The Center Director and NMARC Steering Committee will monitor progress of all pilot projects. Pilot project progress will be reviewed tri-annually by the NMARC Steering Committee and annually by the Program Advisory Committee. The Pilot Project Core goals have been successfully accomplished during the first 3½ years of the first five-year phase of the NMARC P50 award. We recruited several new investigators from diverse fields into the FASD research field. Two R21 and one R01 grants were obtained using preliminary data collected under the support of the Pilot Project Core. A total of 7 peer-reviewed papers have been published or submitted by Pilot Project Core investigators. Support was preferentially provided to junior faculty members. The Pilot Project Core will support two projects during the first two years. Project 6A will test the hypothesis that miR-150 inhibits Vezf1 to alter angiogenesis in the developing cortices of mice prenatally exposed to alcohol (P.I. Amy Gardiner, Ph.D., Research Assistant Professor, Dept of Neurosciences). Project 6B will investigate the effects of prenatal ethanol exposure on astrocyte and oligodendrocyte development in vivo (P.I. Tou Yia Vue, Ph.D., Assistant Professor, Dept of Neurosciences).