NMARC Pilot Project Core C6

NMARC 试点项目核心 C6

• 批准号: 10442638
• 负责人: Carlos Fernando Valenzuela
• 金额: $ 13.23万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442638
• 关键词: Advisory Committees; Alcohols; Applications Grants; Area; Astrocytes; Award; Behavioral; Cell physiology; Cells; Clinical; Communities; Complement; Data; Development; Diagnosis; Doctor of Philosophy; Ethanol; Extramural Activities; Faculty; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fostering; Foundations; Functional disorder; Funding; Goals; Grant; Growth; Head; Institution; Intervention; Mentors; Mind-Body Method; Monitor; Mus; Neurosciences; New Mexico; Oligodendroglia; Paper; Peer Review; Phase; Pilot Projects; Play; Positioning Attribute; Preparation; Publishing; Research; Research Activity; Research Assistant; Research Personnel; Research Project Grants; Research Support; Resources; Role; Testing; alcohol research; angiogenesis; applied behavior analysis; base; circular RNA; fetal; in vivo; member; novel strategies; pain processing; professor; programs; recruit; success

The overall goal of the Pilot Project Core of the New Mexico Alcohol Research Center (NMARC) is to foster cross-disciplinary FASD research across campus and promote growth of the Center. The Core will provide a critical opportunity to develop new basic, translational and clinical fetal alcohol research projects that complement and broaden the NMARC's research program portfolio. Selected projects must fit within the context of the Center's three strategic objectives as well as build on the overall integration and sustainability of the Center's research activities. Pilot projects will be funded for up to 2 years. The goal of each pilot project is to obtain sufficient preliminary data to develop competitive research grant applications and cultivate new investigators that will form part of the center. Support from the NMARC Pilot Project Core has played a crucial role in the success of R21 and/or R01 applications submitted by center investigators. Importantly, our Pilot Project Core has opened new and important research areas in the FASD field (e.g., impact of PAE on place cell, grid cell, and head direction cell function; effect of PAE on pain processing; interaction between placental dysfunction and PAE) and has brought novel approaches into the field (e.g., applied behavioral analysis in FASD management; circular RNA studies). The Core will primarily support new investigators that have yet to obtain substantial independent research support. A year prior to the end of the Pilot Projects that are initially funded, a call for additional Pilot Project proposals will be widely advertised within the scientific community at UNM, the Mind Research Network, and neighboring institutions. Each project will have an Advisory Team composed of senior alcohol researchers with complementary scientific expertise to that of the pilot project PI. The Center Director and NMARC Steering Committee will monitor progress of all pilot projects. Pilot project progress will be reviewed tri-annually by the NMARC Steering Committee and annually by the Program Advisory Committee. The Pilot Project Core goals have been successfully accomplished during the first 3½ years of the first five-year phase of the NMARC P50 award. We recruited several new investigators from diverse fields into the FASD research field. Two R21 and one R01 grants were obtained using preliminary data collected under the support of the Pilot Project Core. A total of 7 peer-reviewed papers have been published or submitted by Pilot Project Core investigators. Support was preferentially provided to junior faculty members. The Pilot Project Core will support two projects during the first two years. Project 6A will test the hypothesis that miR-150 inhibits Vezf1 to alter angiogenesis in the developing cortices of mice prenatally exposed to alcohol (P.I. Amy Gardiner, Ph.D., Research Assistant Professor, Dept of Neurosciences). Project 6B will investigate the effects of prenatal ethanol exposure on astrocyte and oligodendrocyte development in vivo (P.I. Tou Yia Vue, Ph.D., Assistant Professor, Dept of Neurosciences).

新墨西哥酒精研究中心（NMARC）试点项目核心的总体目标是培养 跨校园的跨学科FASD研究并促进该中心的增长。核心将提供 开发新的基本，翻译和临床胎儿酒精研究项目的关键机会 补充并扩大了NMARC的研究计划组合。选定的项目必须适合 该中心的三个战略目标的背景以及建立在总体整合和可持续性的基础上 该中心的研究活动。试点项目将最多资助2年。每个试点项目的目标是 获得足够的初步数据来开发竞争性研究赠款应用并培养新的 将构成中心一部分的调查人员。 NMARC飞行员项目Core的支持发挥了至关重要的作用 中心研究人员提交的R21和/或R01应用程序成功中的角色。重要的是，我们的飞行员 Project Core已在FASD领域开设了新的重要研究领域（例如，Pae对当地的影响 细胞，网格电池和头部方向细胞功能； PAE对疼痛处理的影响；位置之间的相互作用 功能障碍和PAE）并将新颖的方法带入了现场（例如，在 FASD管理；圆形RNA研究）。核心将主要支持尚未进行的新调查员 获得大量的独立研究支持。试点项目结束前一年 资助，将在科学界的广泛宣传其他飞行员项目建议的呼吁 UNM，思维研究网络和邻近机构。每个项目都有一个咨询团队 由PIPOT Project Pi的高级酒精研究人员组成，具有完全的科学专业知识。 中心主任兼NMARC指导委员会将监视所有试点项目的进度。试点项目 NMARC指导委员会将对进度进行审查，并每年由该计划审查 咨询委员会。飞行员项目核心目标已在第一个3½中成功实现 NMARC P50奖的第一个五年阶段的年份。我们从 进入FASD研究领域的不同领域。使用初步获得了两个R21和一个R01赠款 在飞行员项目核心的支持下收集的数据。总共有7篇由同行评审的论文 由Pilot Project核心调查人员发布或提交。优先为初级教师提供支持 成员。试点项目核心将在头两年中支持两个项目。项目6A将测试 假设miR-150抑制VEZF1改变产前小鼠发育中的皮质的血管生成 暴露于酒精（P.I. Amy Gardiner，博士学位，神经科学系研究助理教授）。项目 6b将研究产前乙醇暴露对星形胶质细胞和少突胶质细胞发育的影响 Vivo（P.I. Tou Yia Vue博士，神经科学系助理教授）。