Hemodynamics and AAA disease: Uncovering the Hidden Connections

血流动力学和 AAA 疾病：揭示隐藏的联系

• 批准号: 8096241
• 负责人: Shawn C. Shadden
• 金额: $ 13.95万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096241
• 关键词: Abdominal Aortic Aneurysm; Acute; Address; Anatomy; Aneurysm; Area; Attention; Behavior; Biomechanics; Biomedical Computing; Blood; Blood Vessels; Blood flow; Caliber; Cardiovascular system; Clinical; Collaborations; Complex; Computational Technique; Computer Simulation; Critical Pathways; Data; Data Collection; Death Rate; Deposition; Development; Diagnosis; Disease; Disease Progression; Enrollment; Exercise; Functional disorder; Funding; Heart Rate; Illinois; Image; Institutes; Lead; Learning; Link; Liquid substance; Lower Extremity; Magnetic Resonance Angiography; Malignant neoplasm of prostate; Measures; Mechanics; Methods; Modeling; Motion; Nature; Pathology; Patients; Pattern; Play; Research Personnel; Rest; Role; Shapes; Structure; System; Systems Theory; Techniques; Technology; Testing; Therapeutic; Thrombus; United States National Institutes of Health; Universities; Vascular Diseases; Work; abdominal aorta; base; fluid flow; follow-up; hemodynamics; innovation; malignant breast neoplasm; models and simulation; novel; prevent; prospective; simulation; sound; tool

DESCRIPTION (provided by applicant): Substantial and mounting evidence suggest that blood flow mechanics (hemodynamics) play a leading role in the development and progression of abdominal aortic aneurysm (AAA) disease. Correspondingly, it is hypoth- esized that increased blood flow through AAA due to exercise may provide an effective means to slow or halt disease progression. Precise understandings of realistic AAA hemodynamics are lacking. The objective of this project is to use innovative computational dynamical systems methods for fluid flow structure analysis to under- stand the specific nature of how blood is transported through AAA, and furthermore, to use this framework to evaluate how flow conditions change from rest to exercise. A synergistic collaboration with the National Center for Biomedical Computing at Stanford, Simbios, is proposed, which leverages expertise at the Illinois Institute of Technology (IIT) in the characterization and analysis of complex transport phenomena with the blood flow simula- tion capabilities and unprecedented wealth of AAA hemodynamics data being generated at Stanford. Simbios will provide AAA blood flow simulation data for patients with small and intermediate sized AAA, and necessary data to reproduce the simulation results, to investigators at IIT, who will use the data to apply computational dynamical systems methods to more precisely characterize transport conditions in the aneurysm. For each patient, the detailed flow structure information resulting from the dynamical systems computations will be compared between rest and exercise conditions to evaluate the biomechanical benefits of acute exercise on AAA hemodynamics. This information will be combined with follow-up images of each aneurysm's progression for prospective clinical correlation to establish the relevance of our findings, and to potentially uncover the biomechanical mechanisms underlying AAA progression. PUBLIC HEALTH RELEVANCE: Abdominal aortic aneurysm (AAA) is a common and morbid disease that garners little public attention. Evi- dence suggests that the nature of blood flow in the abdominal aorta is largely responsible for AAA initiation and progression. We aim to use novel computational techniques to study blood flow patterns in AAA. The more we learn about the mechanisms underlying AAA pathology, the better equipped we will be to prevent, diagnose and less-invasively treat this devastating disease.

描述（由申请人提供）：大量和持续的证据表明，血流力学（血液动力学）在腹部主动脉瘤（AAA）疾病的发育和进展中起主要作用。相应地，可以假设，由于运动而增加的血液流经AAA可能会提供有效的方法来缓慢或停止疾病进展。缺乏对现实的AAA血液动力学的精确理解。该项目的目的是使用创新的计算动力学系统方法进行流体流量结构分析，以了解如何通过AAA运输血液的特定性质，并使用该框架来评估流动条件如何从静止变化到运动。提出了与斯坦福大学斯坦福大学国家生物医学计算中心的协同合作，该中心提出了在伊利诺伊州技术研究所（IIT）的专业知识，以对复杂的运输现象的表征和分析，并分析血液流量模拟能力，并在Stanford的AAA血液模型数据生成的AAA血液模型数据的财富。 Simbios将为IIT的研究人员提供小型和中等大小的AAA的患者，并为仿真结果复制仿真结果的患者提供AAA血流模拟数据，他们将使用数据应用计算动力学系统方法来更精确地表征动脉瘤中的传输条件。对于每个患者，将在休息和运动条件之间比较由动态系统计算产生的详细流动结构信息，以评估AAA血液动力学上急性运动的生物力学益处。这些信息将与每种动脉瘤进展的前瞻性临床相关性的后续图像相结合，以确定我们发现的相关性，并有可能发现AAA进展的生物力学机制。 公共卫生相关性：腹部主动脉瘤（AAA）是一种常见且病态的疾病，很少引起公众关注。证据表明，腹主动脉中血流的性质在很大程度上是AAA的开始和进展的原因。我们的目标是使用新颖的计算技术来研究AAA中的血流模式。我们了解AAA病理学基础的机制越多，我们将为预防，诊断和侵入性治疗这种毁灭性疾病的能力越大。