Work Outcomes of Colon and Rectal Cancer Survivors

结肠癌和直肠癌幸存者的工作成果

• 批准号: 8112235
• 负责人: ANDREA M BARSEVICK
• 金额: $ 22.14万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112235
• 关键词: Activities of Daily Living; Address; Adjuvant; Adjuvant Chemotherapy; Affect; African American; Aftercare; Age; Age-Years; Back; Biological Preservation; Breast; Calendar; Cancer Survivor; Colon; Colon Carcinoma; Demographic Factors; Diagnosis; Disease; Elements; Emotional; Ensure; European; Evaluation; Face; Fatigue; Future; Goals; Health; Health Insurance; Individual; Intervention; Intervention Trial; Interview; Intestines; Job Satisfaction; Life; Mails; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Meta-Analysis; Modeling; Neurobehavioral Manifestations; Neuropathy; Normalcy; Occupations; Operative Surgical Procedures; Outcome; Outcome Study; Patient Self-Report; Pennsylvania; Prostate; Psyche structure; Quality of life; Race; Radiation therapy; Reading; Recovery; Rectal Cancer; Regional Disease; Regression Analysis; Research; Research Methodology; Risk; Risk Factors; Sampling; Severities; Sleeplessness; Sphincter; Stomas; Surveys; Survivors; Symptoms; Testing; Time; Unemployment; Visual impairment; Work; Workload; Workplace; base; cancer diagnosis; functional status; health care economics; hearing impairment; interest; modifiable risk; neoplasm registry; neurotoxicity; outcome forecast; palliative; population based; response; satisfaction; urinary

DESCRIPTION (provided by applicant): Colon and rectal cancer survivors face unique challenges that could influence their ability to work after completion of treatment. However, these challenges have not been studied. The aim of this research is to characterize work outcomes for colon and rectal cancer survivors with regard to the influence of symptoms, functional status, and work situational factors. The main hypothesis that will be evaluated is: for colon or rectal cancer survivors, medical and demographic factors, symptoms, functional status and work situational factors will be associated with work outcomes. An exploratory hypothesis is: compared with colon cancer survivors, a higher number and severity of symptoms and poorer functional status will be associated with poorer work outcomes for rectal cancer survivors (controlling for work situation factors and demographic and medical factors). The research method will be a population-based mailed survey. The Pennsylvania Cancer Registry will draw a sample of 664 living survivors (half with colon and half with rectal cancer). African Americans will be oversampled to comprise 15% of the final sample to ensure that race can be evaluated as a covariate. The final sample will consist of 300 completed surveys. The primary dependent variable of interest is work outcomes at the time of the survey. Eligible individuals will include: 1) survivors of non-metastatic colon or rectal cancer (local or regional disease) who were diagnosed in the same calendar year and have completed primary treatment (surgery, neo-adjuvant and/or adjuvant chemotherapy, and/or radiotherapy) by the time of the survey; 2) were employed in a paid job at the time of cancer diagnosis; 3) self-reported that they are clinically free of cancer; 4) are between the ages of 25 and 70 years of age; 5) read and understand English; and 6) have no visual or hearing impairment that would interfere with the completion of the survey or interview. Individuals will be excluded if they were not employed in a paid job at the time of cancer diagnosis or are currently undergoing therapy for metastatic disease or palliative intent. For hypothesis 1, multiple regression analysis will be performed separately for each diagnosis and each work outcome: work status, work intensity, time to return to work, and satisfaction with work. Medical and demographic factors, symptoms, functional status, and work situation variables will be evaluated for association with work outcomes. To test exploratory hypothesis 2, two regression models will be compared to evaluate differential outcomes for colon and rectal cancer survivors. This research has the potential to identify modifiable risk factors for poor work outcomes. The findings will aid in identifying targets for future intervention trials. PUBLIC HEALTH RELEVANCE: With advances in diagnosis and treatment, colon and rectal cancer (CRC) survivors can concern themselves with quality of life issues, including work, instead of focusing exclusively on diagnosis, treatment, and prognosis. It is not well-known to what extent CRC diagnosis and treatment affects work outcomes. Research is warranted to understand how symptoms, functional status, and work situation factors influence work outcomes so that modifiable factors can be identified and interventions to facilitate the transition back to the workplace can be developed.

描述（由申请人提供）：结肠癌和直肠癌幸存者面临着独特的挑战，可能会影响他们完成治疗后的工作能力。然而，这些挑战尚未得到研究。本研究的目的是描述结肠癌和直肠癌幸存者的症状，功能状态和工作情境因素的影响方面的工作成果。将评估的主要假设是：对于结肠癌或直肠癌幸存者，医疗和人口统计学因素，症状，功能状态和工作情境因素将与工作成果相关。一个探索性假设是：与结肠癌幸存者相比，直肠癌幸存者的症状数量和严重程度更高，功能状态更差，工作结果更差（控制工作情况因素和人口统计学和医学因素）。研究方法将是以人口为基础的邮寄调查。宾夕法尼亚州癌症登记处将抽取664名幸存者（一半患有结肠癌，一半患有直肠癌）。将对非裔美国人进行过采样，使其占最终样本的15%，以确保人种可作为协变量进行评价。最后的样本将包括300份已完成的调查。感兴趣的主要因变量是调查时的工作成果。符合条件的个人将包括：1）非转移性结肠癌或直肠癌的幸存者（本地或区域疾病）在同一日历年被诊断并已完成初级治疗（手术、新辅助和/或辅助化疗和/或放疗）; 2）在癌症诊断时从事有薪工作; 3）自我报告他们在临床上没有癌症; 4）年龄在25至70岁之间; 5）能够阅读并理解英语; 6）没有视觉或听觉障碍，不会影响调查或访谈的完成。如果个人在癌症诊断时没有从事有薪工作，或者目前正在接受转移性疾病或姑息治疗，则将被排除在外。对于假设1，将对每项诊断和每项工作成果分别进行多元回归分析：工作状态、工作强度、返回工作的时间和对工作的满意度。将评估医疗和人口统计学因素、症状、功能状态和工作情况变量与工作成果的关联。为了检验探索性假设2，将比较两个回归模型，以评价结肠癌和直肠癌幸存者的差异结局。这项研究有可能确定工作成果不佳的可改变的风险因素。这些发现将有助于确定未来干预试验的目标。 公共卫生相关性：随着诊断和治疗的进步，结肠癌和直肠癌（CRC）幸存者可以关注生活质量问题，包括工作，而不是只关注诊断，治疗和预后。目前还不清楚CRC诊断和治疗在多大程度上影响工作成果。研究是必要的，以了解症状，功能状态和工作情况因素如何影响工作成果，以便可以确定可修改的因素，并制定干预措施，以促进过渡到工作场所。