Predictors of Adolescent Sperm Banking: Development of a Profiling and Referral T

青少年精子库的预测因素：分析和推荐 T 的开发

• 批准号: 8105409
• 负责人: James Klosky
• 金额: $ 19.48万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105409
• 关键词: Address; Adolescent; Adult; Adverse effects; Affect; Age; Anxiety; Biological Preservation; Clinical; Communication; Cryopreservation; Development; Diagnosis; Distress; Failure; Fertility; Frequencies; Health Personnel; Infertility; Intervention; Knowledge; Light; Male Adolescents; Malignant Neoplasms; Medical; Modeling; Newly Diagnosed; Outcome; Parents; Patients; Physicians; Population; Population Intervention; Predictive Factor; Provider; Psychological Factors; Religion and Spirituality; Reporting; Research Design; Risk; Risk Factors; Socioeconomic Status; Specific qualifier value; Sperm Banks; Teenagers; base; cancer diagnosis; cancer therapy; childhood cancer survivor; design; health belief; instrument; leukemia; leukemia/lymphoma; men; novel; psychologic; psychological distress; public health relevance; sperm cell; therapy design; tool

DESCRIPTION (provided by applicant): Despite the known adverse effects of specific cancer treatments on fertility, only 18-26% of at-risk adolescents and young men cryopreserve sperm prior to cancer treatment in the US. These already less than optimal rates of sperm banking are even lower among adolescents who have increased anxiety at cancer diagnosis, are lower in age and socioeconomic status, of Evangelical religious orientation, or are diagnosed with leukemia/lymphoma. It is not clear why sperm banking is underutilized, particularly in light of the high priority that survivors of childhood cancer place on fertility and the high psychological distress associated with fertility loss. Studies addressing sperm banking among adults with cancer suggest that factors such as poor physician communication and the resulting lack of fertility-risk knowledge by patients contributes to the low frequency of sperm cryopreservation. No well-designed studies have examined risk factors associated with failure to bank sperm among adolescents with cancer, a developmentally distinct population ripe for intervention. We propose to identify factors predictive of sperm banking/not sperm banking in order to design interventions for increasing fertility preservation among adolescent males newly diagnosed with cancer. Specifically, we aim to investigate psychological, demographic, developmental, parent/guardian, provider, and medical factors predictive of sperm banking outcomes among at-risk adolescents with cancer. Once these factors have been identified, we will develop a novel Profiling and Referral Tool. This instrument will ultimately serve as an intervention for both healthcare providers and adolescents through the facilitation of appropriate referrals, and tailored interventions for decreasing barriers to sperm banking. Finally, the feasibility of the Profiling and Referral tool will be evaluated based on provider and patient report. PUBLIC HEALTH RELEVANCE: Approximately 10% of adults in the US are affected by infertility-related distress. Knowledge gained from this study may prove to be useful in providing psychological interventions for this population.

描述（由申请人提供）：尽管已知特定癌症治疗对生育力有不良影响，但在美国，只有18-26%的高危青少年和年轻男性在癌症治疗前冷冻保存精子。对于癌症诊断焦虑增加、年龄和社会经济地位较低、具有福音派宗教倾向或被诊断患有白血病/淋巴瘤的青少年来说，这些已经低于最佳的精子储存率甚至更低。目前尚不清楚为什么精子库没有得到充分利用，特别是考虑到儿童癌症幸存者对生育能力的高度重视以及与生育能力丧失相关的高度心理困扰。针对成年癌症患者精子库的研究表明，医生沟通不畅以及患者缺乏生育风险知识等因素导致精子冷冻保存频率较低。没有精心设计的研究已经检查了与青少年癌症患者精子库失败相关的风险因素，这是一个发育独特的人群，适合进行干预。我们建议确定精子库/非精子库的预测因素，以设计干预措施，提高新诊断患有癌症的青少年男性的生育能力。具体来说，我们的目标是调查心理，人口统计学，发展，父母/监护人，提供者和医疗因素预测精子库的结果在高危青少年癌症。一旦确定了这些因素，我们将开发一个新的分析和转介工具。该工具最终将通过促进适当的转诊和针对减少精子库障碍的干预措施，作为医疗保健提供者和青少年的干预措施。最后，将根据提供者和患者报告评估分析和转诊工具的可行性。 公共卫生相关性：在美国，大约10%的成年人受到与不育相关的困扰。从这项研究中获得的知识可能被证明是有用的，为这一人群提供心理干预。