Implementation of a Provider-Focused Intervention for Maximizing HPV Vaccine Uptake in Young Cancer Survivors receiving Follow-Up Care in Pediatric Oncology Practices: A Cluster-Randomized Trial

实施以提供者为中心的干预措施，以最大限度地提高在儿科肿瘤实践中接受后续护理的年轻癌症幸存者的 HPV 疫苗接种：整群随机试验

• 批准号: 10076219
• 负责人: James Klosky
• 金额: $ 185.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-18 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10076219
• 关键词: 17 year old; Address; Adolescent; Age; Area; Cancer Survivor; Cancer Survivorship; Caring; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Cluster randomized trial; Communication; Confidence Intervals; Coupled; Disease; Effectiveness; Ensure; Evidence based intervention; Feedback; Future; General Population; Geography; Guidelines; Health Personnel; Health Promotion; Health behavior; Healthcare; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Hybrids; Immune; Immunization; Intervention; Knowledge; Malignant Neoplasms; Methods; Mission; Morbidity - disease rate; National Cancer Institute; Neoplasms; Odds Ratio; Oncogenic; Oncology; Outcome; Outcomes Research; Parents; Patients; Pediatric Oncology; Population; Prevention; Provider; Public Health; Randomized; Recommendation; Recovery; Research; Research Priority; Sampling; Secondary Cancer Prevention; Series; Survivors; Testing; Time; Training; United States National Institutes of Health; Vaccination; Vaccines; Vulnerable Populations; age group; cancer therapy; care providers; cervical and anal cancer; childhood cancer survivor; chronic infection; design; disability; effectiveness evaluation; effectiveness testing; evidence base; follow-up; health care delivery; health disparity; high risk; implementation science; implementation strategy; improved; intervention program; peer; post intervention; prevent; skills; success; survivorship; therapy development; uptake; young cancer survivor

PROJECT SUMMARY/ABSTRACT Childhood cancer survivors are at high risk for developing new cancers (such as cervical and anal cancer) caused by persistent infection with the human papillomavirus (HPV). An effective vaccine exists that can prevent these cancers, but uptake of the HPV vaccine is low among young cancer survivors (fewer than 1 in 4 have received the vaccine). Lack of a healthcare provider recommendation for the HPV vaccine is the most common reason that cancer survivors fail to get the HPV vaccine. Strategies that are most successful in increasing HPV vaccine uptake in the general population focus on improving healthcare provider knowledge about the HPV vaccine, enhancing the skills that healthcare providers need to effectively recommend the vaccine to young people and their parents, and reducing barriers to receiving the vaccine. This proposed research will evaluate the effectiveness and implementation of an evidence-based intervention, adapted for use by healthcare providers in pediatric oncology clinics, to increase the uptake of HPV vaccine among young cancer survivors (9 to 17 years of age and at least one year off-therapy). If the intervention is effective in improving and sustaining increased uptake of the HPV vaccine in young cancer survivors, this study will contribute important information needed to move forward with testing the widespread use of the intervention in pediatric oncology practices. This proposed research addresses improving healthcare delivery and clinical outcomes for cancer survivors through prevention of HPV-associated cancers, which are high-priority research areas for the National Cancer Institute.

项目总结/文摘