Implementation of a Provider-Focused Intervention for Maximizing HPV Vaccine Uptake in Young Cancer Survivors receiving Follow-Up Care in Pediatric Oncology Practices: A Cluster-Randomized Trial

项目总结/摘要 儿童癌症幸存者患新癌症（如宫颈癌和肛门癌）的风险很高 由人乳头瘤病毒（HPV）持续感染引起。有一种有效的疫苗可以预防 这些癌症，但HPV疫苗的摄取率在年轻的癌症幸存者中很低（不到四分之一的人 接种疫苗）。缺乏医疗保健提供者对HPV疫苗的推荐是最常见的 癌症幸存者无法获得HPV疫苗的原因。在增加HPV方面最成功的策略 一般人群的疫苗接种重点是提高医疗保健提供者对HPV的了解 疫苗，提高医疗保健提供者向年轻人有效推荐疫苗所需的技能 人们和他们的父母，并减少接受疫苗的障碍。这项研究将评估 基于证据的干预措施的有效性和实施，适用于医疗保健提供者 在儿科肿瘤诊所，增加年轻癌症幸存者（9至17岁）的HPV疫苗接种率 年龄和至少一年的治疗）。如果干预措施有效地改善和维持了 在年轻的癌症幸存者中HPV疫苗的摄取，这项研究将提供所需的重要信息， 进一步测试在儿科肿瘤学实践中广泛使用的干预措施。这一拟议 研究致力于通过预防改善癌症幸存者的医疗服务和临床结果 HPV相关的癌症，这是国家癌症研究所的高度优先研究领域。

PROJECT SUMMARY/ABSTRACT Childhood cancer survivors are at high risk for developing new cancers (such as cervical and anal cancer) caused by persistent infection with the human papillomavirus (HPV). An effective vaccine exists that can prevent these cancers, but uptake of the HPV vaccine is low among young cancer survivors (fewer than 1 in 4 have received the vaccine). Lack of a healthcare provider recommendation for the HPV vaccine is the most common reason that cancer survivors fail to get the HPV vaccine. Strategies that are most successful in increasing HPV vaccine uptake in the general population focus on improving healthcare provider knowledge about the HPV vaccine, enhancing the skills that healthcare providers need to effectively recommend the vaccine to young people and their parents, and reducing barriers to receiving the vaccine. This proposed research will evaluate the effectiveness and implementation of an evidence-based intervention, adapted for use by healthcare providers in pediatric oncology clinics, to increase the uptake of HPV vaccine among young cancer survivors (9 to 17 years of age and at least one year off-therapy). If the intervention is effective in improving and sustaining increased uptake of the HPV vaccine in young cancer survivors, this study will contribute important information needed to move forward with testing the widespread use of the intervention in pediatric oncology practices. This proposed research addresses improving healthcare delivery and clinical outcomes for cancer survivors through prevention of HPV-associated cancers, which are high-priority research areas for the National Cancer Institute.