Engineering Particle Nanostructure for Enhanced Bioadhesion
用于增强生物粘附的工程颗粒纳米结构
基本信息
- 批准号:8074412
- 负责人:
- 金额:$ 21.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2013-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAffectApicalArchitectureAttenuatedBiocompatibleBiological AvailabilityBlood CirculationCategoriesCellsCellular MorphologyChargeChemistryClinicalDataDevelopmentDevicesDrug Administration RoutesDrug Delivery SystemsEndocytosisEngineeringEnteralEnvironmentEpithelialEpitheliumFluorescenceGastrointestinal tract structureImageIn VitroInjection of therapeutic agentMechanicsMediatingMicrospheresModelingModificationMorphologyNanostructuresNanotechnologyNatureOralPermeabilityPharmaceutical PreparationsPhysiologicalProcessPropertyProtocols documentationResearchRoleShapesSurfaceSystemTechnologyTestingTherapeuticTight JunctionsTimeTissue EngineeringVariantcellular microvilluschemical stabilitycytotoxicitydesigngastrointestinalimmunogenicityin vitro testingin vivointestinal epitheliumlocal drug deliverymacromoleculenanofabricationnanoparticlenanoscalenanostructurednanowireparticlepublic health relevanceresearch studyresidenceresponsesurface coatingvan der Waals force
项目摘要
DESCRIPTION (provided by applicant): Oral delivery remains the preferred route for drug administration. However, therapeutic macromolecular drugs currently under development suffer from poor oral bioavailability. Nanotechnology may offer potential advantages over conventional drug delivery stratagems. In this proposal, we investigate nanofabrication approaches to create nanowire interfaces which promote bioadhesion under dynamic conditions. We examine nanostructure interactions with the underlying epithelium and the use of such interfaces to enhance the local delivery of drugs. The long-term objective of this proposal is to develop a new platform for oral delivery of pharmacologically active macromolecules into the systemic circulation via the creation of a robust bioadhesive delivery system. We propose the following specific aims: Specific Aim 1: Refine processes for optimal fabrication of highly uniform nanowire platforms of controllable size, feature geometry, mechanical integrity and uniformity Specific Aim 2: Examine mechanism of cell-nanowire bioadhesion and effects on drug release in vitro Specific Aim 3: Determine the in vivo bioadhesion of nanostructure particles using fluorescent imaging and microCT We expect to find that our nanowire-particles display enhanced bioadhesion compared to chemically modified particles. This may allow for an increase in particle residence time at the epithelial interface. In addition, the use of nanoarchitecture to enhance particle stability may mitigate issues associated with the stability of chemical modification in the GI system.
PUBLIC HEALTH RELEVANCE: Oral delivery remains the preferred route for drug administration, particularly in the U.S. However, there are several issues related to adequate drug bioavailability and localization with the GI tract. We propose the use of nanostructure interfaces to enhance the bioadhesion of delivery devices to the GI tract.
性状(由申请方提供):口服给药仍然是首选给药途径。然而,目前正在开发的治疗性大分子药物具有较差的口服生物利用度。纳米技术可能提供比传统的药物输送策略的潜在优势。在这个建议中,我们研究纳米纤维的方法来创建纳米线接口,促进动态条件下的生物粘附。我们研究了纳米结构与下层上皮的相互作用,以及使用这种界面来增强药物的局部递送。该提案的长期目标是开发一种新的平台,通过创建一种稳健的生物粘附递送系统,将生物活性大分子口服递送到体循环中。我们提出了以下具体目标:具体目标1:优化工艺,以最佳制造具有可控尺寸、特征几何形状、机械完整性和均匀性的高度均匀的纳米线平台具体目标2:检查细胞-纳米线生物粘附的机制和对体外药物释放的影响具体目标3:使用荧光成像和microCT确定纳米结构颗粒的体内生物粘附性我们期望发现我们的纳米线-与化学改性的颗粒相比,颗粒显示出增强的生物粘附。这可以允许增加颗粒在上皮界面处的停留时间。此外,使用纳米结构来增强颗粒稳定性可以减轻与GI系统中化学修饰的稳定性相关的问题。
公共卫生关系:口服给药仍然是首选的给药途径,特别是在美国。然而,有几个问题与足够的药物生物利用度和定位与胃肠道。我们建议使用纳米结构界面来增强递送装置对胃肠道的生物粘附。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Emerging microtechnologies for the development of oral drug delivery devices.
- DOI:10.1016/j.addr.2012.08.013
- 发表时间:2012-11
- 期刊:
- 影响因子:16.1
- 作者:Chirra, Hariharasudhan D.;Desai, Tejal A.
- 通讯作者:Desai, Tejal A.
Hierarchical nanoengineered surfaces for enhanced cytoadhesion and drug delivery.
- DOI:10.1016/j.biomaterials.2011.01.022
- 发表时间:2011-05
- 期刊:
- 影响因子:14
- 作者:Fischer, Kathleen E.;Nagaraj, Ganesh;Daniels, R. Hugh;Li, Esther;Cowles, Verne E.;Miller, Jennifer L.;Bunger, Mark D.;Desai, Tejal A.
- 通讯作者:Desai, Tejal A.
Nanoengineered surfaces enhance drug loading and adhesion.
- DOI:10.1021/nl103951e
- 发表时间:2011-03-09
- 期刊:
- 影响因子:10.8
- 作者:Fischer KE;Jayagopal A;Nagaraj G;Daniels RH;Li EM;Silvestrini MT;Desai TA
- 通讯作者:Desai TA
Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices.
- DOI:10.1021/nn3019865
- 发表时间:2012-09-25
- 期刊:
- 影响因子:17.1
- 作者:Uskokovic, Vuk;Lee, Kunwoo;Lee, Phin Peng;Fischer, Kathleen E.;Desai, Tejal A.
- 通讯作者:Desai, Tejal A.
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Tejal A. Desai其他文献
Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse
磷酸钙纳米簇可调节牙周组织重塑并最大程度减少正畸复发
- DOI:
10.1016/j.biomaterials.2024.122965 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:12.900
- 作者:
Darnell L. Cuylear;Moyu L. Fu;Justin C. Chau;David Bulkley;Bhushan Kharbikar;Galateia J. Kazakia;Andrew H. Jheon;Stefan Habelitz;Sunil D. Kapila;Tejal A. Desai - 通讯作者:
Tejal A. Desai
Implantation of engineered adipocytes suppresses tumor progression in cancer models
工程化脂肪细胞的植入抑制了癌症模型中的肿瘤进展
- DOI:
10.1038/s41587-024-02551-2 - 发表时间:
2025-02-04 - 期刊:
- 影响因子:41.700
- 作者:
Hai P. Nguyen;Kelly An;Yusuke Ito;Bhushan N. Kharbikar;Rory Sheng;Breanna Paredes;Elizabeth Murray;Kimberly Pham;Michael Bruck;Xujia Zhou;Cassandra Biellak;Aki Ushiki;Mai Nobuhara;Sarah L. Fong;Daniel A. Bernards;Filipa Lynce;Deborah A. Dillon;Mark Jesus M. Magbanua;Laura A. Huppert;Heinz Hammerlindl;Jace Anton Klein;Luis Valdiviez;Oliver Fiehn;Laura Esserman;Tejal A. Desai;Sook Wah Yee;Jennifer M. Rosenbluth;Nadav Ahituv - 通讯作者:
Nadav Ahituv
Islet encapsulation therapy — racing towards the finish line?
胰岛包囊疗法——正冲向终点线吗?
- DOI:
10.1038/s41574-018-0100-7 - 发表时间:
2018-10-01 - 期刊:
- 影响因子:40.000
- 作者:
Tejal A. Desai;Qizhi Tang - 通讯作者:
Qizhi Tang
Insights from an AIMBE Workshop: Diversifying Paths to Academic Leadership
AIMBE 研讨会的见解:学术领导力的多元化路径
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Beth l. Pruitt;N. Chesler;Rena Seltzer;O. Eniola;S. Margulies;M. Campo;Scott I. Simon;M. Grimm;Sarah Mandell;Andrew Alleyne;Jennifer L. West;Tejal A. Desai - 通讯作者:
Tejal A. Desai
Long acting systemic HIV pre-exposure prophylaxis: an examination of the field
- DOI:
10.1007/s13346-017-0391-6 - 发表时间:
2017-06-13 - 期刊:
- 影响因子:5.500
- 作者:
William R. Lykins;Ellen Luecke;Daniel Johengen;Ariane van der Straten;Tejal A. Desai - 通讯作者:
Tejal A. Desai
Tejal A. Desai的其他文献
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{{ truncateString('Tejal A. Desai', 18)}}的其他基金
Regulation of epithelial function using targeted nanowires
使用靶向纳米线调节上皮功能
- 批准号:
10453894 - 财政年份:2022
- 资助金额:
$ 21.66万 - 项目类别:
Regulation of epithelial function using targeted nanowires
使用靶向纳米线调节上皮功能
- 批准号:
10677028 - 财政年份:2022
- 资助金额:
$ 21.66万 - 项目类别:
ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.
ACE2 靶向 PET 放射性示踪剂用于研究 SARS-CoV-2 器官损伤和治疗反应的时空分布。
- 批准号:
10391190 - 财政年份:2021
- 资助金额:
$ 21.66万 - 项目类别:
ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.
ACE2 靶向 PET 放射性示踪剂用于研究 SARS-CoV-2 器官损伤和治疗反应的时空分布。
- 批准号:
10681427 - 财政年份:2021
- 资助金额:
$ 21.66万 - 项目类别:
UCSF/UCB Joint Graduate Group in Bioengineering
UCSF/UCB 生物工程联合研究生小组
- 批准号:
10089723 - 财政年份:2021
- 资助金额:
$ 21.66万 - 项目类别:
ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.
ACE2 靶向 PET 放射性示踪剂用于研究 SARS-CoV-2 器官损伤和治疗反应的时空分布。
- 批准号:
10490883 - 财政年份:2021
- 资助金额:
$ 21.66万 - 项目类别:
Microstructural Cues for the Treatment of Heart Failure
治疗心力衰竭的微观结构线索
- 批准号:
10078623 - 财政年份:2017
- 资助金额:
$ 21.66万 - 项目类别:
Mechanisms of nanostructure-enhanced transepithelial drug delivery
纳米结构增强的跨上皮药物递送机制
- 批准号:
9085108 - 财政年份:2014
- 资助金额:
$ 21.66万 - 项目类别:
Mechanisms of nanostructure-enhanced transepithelial drug delivery
纳米结构增强的跨上皮药物递送机制
- 批准号:
8748142 - 财政年份:2014
- 资助金额:
$ 21.66万 - 项目类别:
Mechanisms of nanostructure-enhanced transepithelial drug delivery
纳米结构增强的跨上皮药物递送机制
- 批准号:
8929244 - 财政年份:2014
- 资助金额:
$ 21.66万 - 项目类别:
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