Dynamical DTI: A method for time-resolved in vivo diffusion tensor imaging

动态 DTI：一种体内时间分辨扩散张量成像方法

• 批准号: 8011729
• 负责人: Eric Edward Sigmund
• 金额: $ 20.31万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-05 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8011729
• 关键词: Algorithms; Alzheimer' s Disease; Animal Model; Anisotropy; Area; Attention; Behavior; Biological Markers; Brain; Brain region; Chronic; Clinical; Compartment syndromes; Complex; Detection; Diabetes Mellitus; Diagnostic; Diffusion; Diffusion Magnetic Resonance Imaging; Diffusion weighted imaging; Ensure; Exertion; Fiber; Functional disorder; Future; Goals; Histocompatibility Testing; Human; Image; Imaging technology; In Situ; Infarction; Infiltration; Inflammation; Injury; Ischemia; Knee; Lesion; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Metric; Microscopic; Monitor; Morphologic artifacts; Morphology; Motion; Multiple Sclerosis; Muscle; Muscle function; Muscular Dystrophies; Musculoskeletal Diseases; Myocardial Infarction; Myocardium; Neurodegenerative Disorders; Noise; Organ; Output; Pathology; Pattern; Phase; Physiologic pulse; Physiological; Population; Positioning Attribute; Process; Productivity; Protocols documentation; Public Health; Radial; Radiology Specialty; Relaxation; Resolution; Rotation; Scanning; Scheme; Series; Signal Transduction; Skeletal Muscle; Stroke; System; Systems Analysis; Techniques; Testing; Time; Tissues; Training; Translating; Validation; Work; body system; clinical application; clinically relevant; design; healthy volunteer; heart motion; image reconstruction; improved; in vivo; indexing; kinematics; musculoskeletal disorder diagnosis; patient population; programs; public health relevance; reconstruction; research study; tool; tumor; virtual; white matter

DESCRIPTION (provided by applicant): Diffusion tensor imaging (DTI) is an established magnetic resonance imaging (MRI) protocol with many clinical applications, especially in the brain. DTI quantitative biomarkers are sensitive to neurodegenerative disease lesions (e.g. multiple sclerosis, Alzheimer's), focal ischemia (stroke), and tissue infiltrations from tumors. The scan also provides a noninvasive means for white matter tissue connectivity via fiber tractography. These tools also have great value in other areas of the body with microscopic anisotropy, particularly skeletal and cardiac muscle. Ex vivo, animal model, and static in vivo imaging has shown the diagnostic value of DTI in cases of ischemia, inflammation, infarct, or muscle injury. However, conventional DTI does not lend itself to temporally dynamic processes, which excludes from view a wide range of important physiological functions. The present proposal is devoted to implementing a new DTI scheme that overcomes this limitation and enables the full diffusion tensor and all of its derived indices to be dynamically monitored. If successful, this effort promises to open an entirely new radiological diagnostic for debilitating musculoskeletal disorders such as muscular dystrophy or diabetes. PUBLIC HEALTH RELEVANCE: The relevance of this project to public health lies in its potential to translate a powerful technique of clinical radiology (diffusion tensor imaging) to the regime of dynamic time-resolved imaging. If successful, it promises to impact diagnosis of musculoskeletal disorders (such as muscular dystrophy, chronic exertional compartment syndrome, or diabetes), by tracking microarchitectural status during muscle exertion. Similarly, in the future, the technique may be applicable to the complex motion of the heart and allow the microscopic tissue state to be dynamically monitored in both the healthy state and in the case of infarct.

描述（由申请人提供）：扩散张量成像（DTI）是一种已建立的磁共振成像（MRI）方案，具有许多临床应用，尤其是在脑部。DTI定量生物标志物对神经退行性疾病病变（例如多发性硬化症、阿尔茨海默氏症）、局灶性缺血（中风）和肿瘤组织浸润敏感。该扫描还通过纤维束成像为白色组织连接提供了一种非侵入性手段。这些工具在具有微观各向异性的身体其他区域也具有很大的价值，特别是骨骼肌和心肌。离体、动物模型和静态体内成像已经显示了DTI在缺血、炎症、梗塞或肌肉损伤的情况下的诊断价值。然而，传统的DTI不适合于时间动态过程，这从视图中排除了广泛的重要生理功能。本建议致力于实现一个新的DTI计划，克服了这一限制，使全扩散张量和所有的衍生指数进行动态监测。如果成功，这一努力有望为肌肉骨骼疾病（如肌肉萎缩症或糖尿病）开辟一种全新的放射学诊断方法。 公共卫生相关性：该项目与公共卫生的相关性在于其将强大的临床放射学技术（扩散张量成像）转化为动态时间分辨成像的潜力。如果成功的话，它有望通过跟踪肌肉运动过程中的微结构状态来影响肌肉骨骼疾病（如肌营养不良症、慢性运动间隔综合征或糖尿病）的诊断。类似地，在未来，该技术可能适用于心脏的复杂运动，并允许在健康状态和梗塞的情况下动态监测微观组织状态。