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Dynamical DTI: A method for time-resolved in vivo diffusion tensor imaging

动态 DTI：一种体内时间分辨扩散张量成像方法

基本信息

批准号：
7791757
负责人：
Eric Edward Sigmund
金额：
$ 25.35万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-05 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7791757
关键词：
Algorithms Alzheimer&apos s Disease Animal Model Anisotropy Area Attention Behavior Biological Markers Brain Brain region Chronic Clinical Compartment syndromes Complex Detection Diabetes Mellitus Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Diffusion weighted imaging Ensure Exertion Fiber Functional disorder Future Goals Histocompatibility Testing Human Image Imaging technology In Situ Infarction Infiltration Inflammation Injury Ischemia Knee Lesion Magnetic Resonance Imaging Maps Measurement Measures Methods Metric Microscopic Monitor Morphologic artifacts Morphology Motion Multiple Sclerosis Muscle Muscle function Muscular Dystrophies Musculoskeletal Diseases Myocardial Infarction Myocardium Neurodegenerative Disorders Noise Organ Output Pathology Pattern Phase Physiologic pulse Physiological Population Positioning Attribute Process Productivity Protocols documentation Public Health Radial Radiology Specialty Relaxation Resolution Rotation Scanning Scheme Series Signal Transduction Skeletal Muscle Stroke System Systems Analysis Techniques Testing Time Tissues Training Translating Validation Work body system clinical application clinically relevant design healthy volunteer heart motion image reconstruction improved in vivo indexing kinematics musculoskeletal disorder diagnosis patient population programs public health relevance reconstruction research study skeletal tool tumor virtual white matter

项目摘要

DESCRIPTION (provided by applicant): Diffusion tensor imaging (DTI) is an established magnetic resonance imaging (MRI) protocol with many clinical applications, especially in the brain. DTI quantitative biomarkers are sensitive to neurodegenerative disease lesions (e.g. multiple sclerosis, Alzheimer's), focal ischemia (stroke), and tissue infiltrations from tumors. The scan also provides a noninvasive means for white matter tissue connectivity via fiber tractography. These tools also have great value in other areas of the body with microscopic anisotropy, particularly skeletal and cardiac muscle. Ex vivo, animal model, and static in vivo imaging has shown the diagnostic value of DTI in cases of ischemia, inflammation, infarct, or muscle injury. However, conventional DTI does not lend itself to temporally dynamic processes, which excludes from view a wide range of important physiological functions. The present proposal is devoted to implementing a new DTI scheme that overcomes this limitation and enables the full diffusion tensor and all of its derived indices to be dynamically monitored. If successful, this effort promises to open an entirely new radiological diagnostic for debilitating musculoskeletal disorders such as muscular dystrophy or diabetes. PUBLIC HEALTH RELEVANCE: The relevance of this project to public health lies in its potential to translate a powerful technique of clinical radiology (diffusion tensor imaging) to the regime of dynamic time-resolved imaging. If successful, it promises to impact diagnosis of musculoskeletal disorders (such as muscular dystrophy, chronic exertional compartment syndrome, or diabetes), by tracking microarchitectural status during muscle exertion. Similarly, in the future, the technique may be applicable to the complex motion of the heart and allow the microscopic tissue state to be dynamically monitored in both the healthy state and in the case of infarct.

描述（由申请人提供）：弥散张量成像（DTI）是一种成熟的磁共振成像（MRI）方案，具有许多临床应用，特别是在脑部。DTI定量生物标志物对神经退行性疾病病变（如多发性硬化症、阿尔茨海默氏症）、局灶性缺血（中风）和肿瘤组织浸润敏感。该扫描还通过纤维束造影提供了一种非侵入性的白质组织连接方法。这些工具在具有微观各向异性的身体其他部位，特别是骨骼肌和心肌，也有很大的价值。离体、动物模型和静态体内成像显示了DTI对缺血、炎症、梗死或肌肉损伤的诊断价值。然而，传统的DTI并不适合于时间动态过程，这排除了广泛的重要生理功能。本文致力于实现一种新的DTI方案，该方案克服了这一限制，并使全扩散张量及其所有派生指标能够动态监测。如果成功，这一努力有望为肌肉萎缩症或糖尿病等衰弱性肌肉骨骼疾病开辟一种全新的放射诊断方法。