Clinical and Basic Studies in Male Reproduction

男性生殖的临床和基础研究

• 批准号: 8065713
• 负责人: George STANLEY MCKNIGHT
• 金额: $ 1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8065713
• 关键词: Address; Agency for International Development; Androgen-Insensitivity Syndrome; Basic Science; Biology; Biophysics; Blood-Testis Barrier; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Commit; Communication; Contraceptive Agents; Contraceptive methods; Development; Discipline; Disease; Environment; Family Planning; Fostering; Foundations; Fred Hutchinson Cancer Research Center; Funding; Genetic; Genome; Germ Cells; Goals; Gonadotropins; Grant; Health; Hormonal; Human; Hypothalamic structure; Individual; Infertility; Institution; Kallmann Syndrome; Knowledge; Leadership; Learning; Medical center; Medicine; Meiosis; Mission; Molecular; Molecular Biology; National Institute of Child Health and Human Development; Neuroendocrinology; Neurosecretory Systems; Oligospermia; Personal Satisfaction; Pharmacology; Physicians; Physiology; Pituitary Gland; Population; Population Control; Recording of previous events; Reproduction; Reproductive Biology; Reproductive Health; Reproductive Medicine; Reproductive Physiology; Reproductive Process; Research; Research Personnel; Research Project Grants; Research Training; Science; Scientist; Sertoli cell only syndrome; Services; Signal Pathway; Spermatogenesis; Structure; Talents; Testis; Training Programs; Translating; United States National Institutes of Health; Universities; Veterans; Washington; Work; World Health Organization; base; clinical practice; design; experience; female reproductive system; hormonal contraception; improved; innovation; male; men; multidisciplinary; post-doctoral training; programs; reproductive; reproductive axis

PROVIDED. This proposal is designed to increase our knowledge and understanding of reproductive biology and medicine in the male. This is a multidisciplinary and collaborative effort among basic scientists and clinical investigators, who are committed to advancing our understanding of reproductive physiology and translate this knowledge into improving human health and well-being. The proposed aims comprise the three major branches of the reproductive axis¿ the hypothalamus, pituitary and testis. The proposed research embraces both basic and clinical investigations, which have direct relevance to understanding certain disorders of human reproduction, including idiopathic hypogonadotropic hypogonadism, androgen insensitivity syndrome, meiotic arrest, Sertoli cell only syndrome, and oligospermia or azoospermia. Our clinical project is focused on understanding the functional significance of the hormonal and genetic environment required for spermatogenesis in men. The basic science projects investigate the neuroendocrine control of gonadotropin secretion, the molecular basis of the blood-testis barrier, and the key signaling pathways that regulate the development and function of mature gametes. Each project involves a collaboration with at least one other in the Center, and the molecular physiology is integrated with the clinical investigation. We believe this approach will offer the best opportunity to provide the scientific rationale for the development of improved therapies to treat certain disorders of reproduction and serve as the basis for the development of better options for hormonal contraception in men. We are committed to scientific excellence and communication across disciplines, ranging from molecular biology to physiology and medicine. Our proposal incorporates the talents of outstanding investigators, whose experience and knowledge represent a rich and broad perspective on reproductive biology and its relevance to human health. We have deliberately structured the Center to bring together the best and most accomplished reproductive biologists and physician-scientists at the University of Washington in a scientific collaboration. We look forward to our continued participation in the NIH Specialized Cooperative Centers Program in Reproductive Research (SCCPRR). We share its goal of fostering communication, innovation and research excellence, with the ultimate goal of improving human reproductive health through accelerated transfer of discoveries made at the bench into clinical practice. We are committed to the collaborative spirit of the SCCPRR and have established collaborations with investigators at SCCPRR Programs at several other institutions. We look forward to contributing to the outstanding clinical and basic research in this important national program.

提供了 该提案旨在增加我们对男性生殖生物学和医学的知识和理解。这是基础科学家和临床研究人员之间的多学科合作努力，他们致力于促进我们对生殖生理学的理解，并将其转化为 将这些知识用于改善人类健康和福祉。拟议的目标包括生殖轴的三个主要分支-下丘脑，垂体和睾丸。拟议的研究包括基础和临床研究，这些研究与理解某些疾病有直接关系。 人类生殖，包括特发性低促性腺激素性腺功能减退症、雄激素不敏感综合征、减数分裂停滞、仅支持细胞综合征和少精子症或无精子症。我们的临床项目的重点是了解所需的激素和遗传环境的功能意义， 男性精子发生基础科学项目研究促性腺激素分泌的神经内分泌控制，血睾丸屏障的分子基础，以及调节成熟配子发育和功能的关键信号通路。每个项目都涉及至少一个其他的合作， 中心，分子生理学与临床研究相结合。我们认为，这种方法将提供最佳机会，为开发治疗某些生殖疾病的改进疗法提供科学依据，并作为开发男性激素避孕更好选择的基础。 我们致力于科学卓越和跨学科的交流，从分子生物学到生理学和医学。我们的建议结合了杰出研究人员的才能，他们的经验和知识代表了生殖生物学及其 与人类健康的相关性。我们特意组织了该中心，以汇集华盛顿大学最优秀、最有成就的生殖生物学家和医学科学家进行科学合作。我们期待着继续参与NIH专业合作中心 生殖研究计划（SCCPRR）。我们的目标是促进交流，创新和卓越的研究，最终目标是通过加速将实验室发现转化为临床实践来改善人类生殖健康。我们致力于SCCPRR的合作精神，并与其他几个机构的SCCPRR项目的研究人员建立了合作关系。我们期待着为这一重要的国家计划中的优秀临床和基础研究做出贡献。