Clinical and Basic Studies in Male Reproduction

男性生殖的临床和基础研究

• 批准号: 7862199
• 负责人: George STANLEY MCKNIGHT
• 金额: $ 1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2009-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7862199
• 关键词: Clinical; Basic; Studies; Male; Reproduction

This proposal is designed to increase our knowledge and understanding of reproductive biology and medicine in the male. This is a multidisciplinary and collaborative effort among basic scientists and clinical investigators, who are committed to advancing our understanding of reproductive physiology and translate this knowledge into improving human health and well-being. The proposed aims comprise the three major branches of the reproductive axis? the hypothalamus, pituitary and testis. The proposed research embraces both basic and clinical investigations, which have direct relevance to understanding certain disorders of human reproduction, including idiopathic hypogonadotropic hypogonadism, androgen insensitivity syndrome, meiotic arrest, Sertoli cell only syndrome, and oligospermia or azoospermia. Our clinical project is focused on understanding the functional significance of the hormonal and genetic environment required for spermatogenesis in men. The basic science projects investigate the neuroendocrine control of gonadotropin secretion, the molecular basis of the blood-testis barrier, and the key signaling pathways that regulate the development and function of mature gametes. Each project involves a collaboration with at least one other in the Center, and the molecular physiology is integrated with the clinical investigation. We believe this approach will offer the best opportunity to provide the scientific rationale for the development of improved therapies to treat certain disorders of reproduction and serve as the basis for the development of better options for hormonal contraception in men. We are committed to scientific excellence and communication across disciplines, ranging from molecular biology to physiology and medicine. Our proposal incorporates the talents of outstanding investigators, whose experience and knowledge represent a rich and broad perspective on reproductive biology and its relevance to human health. We have deliberately structured the Center to bring together the best and most accomplished reproductive biologists and physician-scientists at the University of Washington in a scientific collaboration. We look forward to our continued participation in the NIH Specialized Cooperative Centers Program in Reproductive Research (SCCPRR). We share its goal of fostering communication, innovation and research excellence, with the ultimate goal of improving human reproductive health through accelerated transfer of discoveries made at the bench into clinical practice. We are committed to the collaborative spirit of the SCCPRR and have established collaborations with investigators at SCCPRR Programs at several other institutions. We look forward to contributing to the outstanding clinical and basic research in this important national program.

这项建议旨在增加我们对生殖生物学的知识和理解，并 男性的药物。这是基础科学家和临床科学家之间的多学科合作努力。 研究人员，他们致力于促进我们对生殖生理学的理解和翻译 将这些知识转化为改善人类健康和福祉的知识。建议的目标包括三大目标 生殖轴的分支？下丘脑、脑下垂体和睾丸。拟议的研究包括 基础和临床调查，这与了解某些疾病有直接关系 人类生殖，包括特发性性腺激素减退症，雄激素不敏感综合征， 减数分裂停滞，仅支持细胞综合征，少精子症或无精子症。我们的临床项目专注于 关于理解激素和遗传环境所需的功能意义 男性的精子发生。基础科学项目研究促性腺激素的神经内分泌控制 分泌，血-睾丸屏障的分子基础，以及调节 成熟配子的发育和功能。每个项目都涉及与至少一个其他项目在 分子生理学与临床研究相结合。我们相信这一点 方法将提供最好的机会，为改进的发展提供科学的理论基础 治疗某些生殖障碍并作为更好发展的基础的疗法 男性荷尔蒙避孕的选择。 我们致力于科学的卓越和跨学科的交流，范围从分子 从生物学到生理学和医学。我们的提案融合了优秀调查员的才华， 他们的经验和知识代表了生殖生物学及其研究的丰富和广阔的前景 与人类健康相关。我们精心设计了该中心的结构，将最好的和最 华盛顿大学杰出的生殖生物学家和内科科学家在科学上 协作。我们期待着继续参与美国国立卫生研究院专业合作中心 生殖研究计划(SCCPRR)。我们赞同其促进沟通、创新的目标 和卓越的研究，其最终目标是通过加速 将在试验台上的发现转化为临床实践。我们致力于 SCCPRR并与SCCPRR项目的调查人员在其他几个地方建立了合作 机构。我们期待着为这一重要领域的杰出临床和基础研究做出贡献。 国家计划。