Medial temporal lobe contributions to episodic memory

内侧颞叶对情景记忆的贡献

• 批准号: 8013042
• 负责人: LILA DAVACHI
• 金额: $ 29.91万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2012-02-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8013042
• 关键词: Address; Aging; Agreement; Alzheimer' s Disease; Architecture; Binding; Brain; Complex; Consensus; Data; Disease; Disease Progression; Episodic memory; Event; Exhibits; Familiarity; Functional Magnetic Resonance Imaging; Functional disorder; Glean; Hippocampus (Brain); Human; Influentials; Investigation; Literature; Maintenance; Medial; Memory; Mental Depression; Modeling; Nature; Performance; Physiological; Positioning Attribute; Process; Psychopathology; Public Health; Research; Resolution; Retrieval; Role; Schizophrenia; Signal Transduction; Specificity; Stimulus; System; Techniques; Temporal Lobe; Testing; Time; association cortex; base; design; insight; memory retrieval; neuromechanism; neuropsychiatry; operation; research study; role model

DESCRIPTION (provided by applicant): The medial temporal lobes (MTL) are the critical substrate for episodic memory. It is undisputed that a division of labor exists within the MTL. However, there is very little consensus as to how to best characterize these distinctions. Although some convergent evidence exists for a division of labor, particularly concerning the distinction between perirhinal and hippocampal encoding processes, the nature of the distinction between perirhinal and parahippocampal cortex has been underspecified. Although there is strong convergence in the literature supporting a role for the hippocampus in relational processing, the role of the MTL cortex in item processing/familiarity is less well defined, and only partially supported by the literature. Importantly, investigation into the extent and form of domain specificity within MTL cortex will contribute substantially to our understanding of episodic memory function. A fundamental hallmark of normal and abnormal aging, as well as some psychopathologies, is the alteration in episodic memory. Through an understanding of the functional architecture of the episodic memory system, great insight can be gleaned into these memory related deficits that, for example, occur during disease progression as a consequence of Alzheimer's disease or have been seen in the pathophysiology of neuropsychiatric disorders such as depression and schizophrenia. Understanding the neural mechanisms underlying the formation of human memory is an important step in efforts to describe and treat conditions that impact memory and will, thus, have a great impact on public health issues regarding treatment of such conditions. The research proposed will use functional magnetic resonance imaging to elucidate the functions of the MTL considering informational domain as being critical to a complete model of MTL organization (Aims 1 and 2). In addition, whether relational encoding and retrieval, thought to be a hallmark of hippocampal function, extends to the binding of episodic events in time will be explored (AIM 3)

描述（由申请人提供）：内侧颞叶（MTL）是情景记忆的关键基底。毫无疑问，MTL内部存在劳动分工。然而，对于如何最好地描述这些区别，几乎没有共识。虽然存在一些趋同的劳动分工的证据，特别是关于嗅周和海马编码过程之间的区别，嗅周和海马旁皮质之间的区别的性质一直未被充分说明。虽然有很强的收敛在文献中支持海马在关系处理中的作用，MTL皮层在项目处理/熟悉的作用是不太好的定义，只有部分文献支持。重要的是，调查的程度和形式的域特异性MTL皮层将有助于我们了解情节记忆功能。正常和异常衰老以及一些精神病理学的一个基本标志是情景记忆的改变。通过对情景记忆系统的功能结构的理解，可以深入了解这些记忆相关的缺陷，例如，在疾病进展期间发生的阿尔茨海默病的结果，或者在神经精神疾病如抑郁症和精神分裂症的病理生理学中看到的。了解人类记忆形成的神经机制是描述和治疗影响记忆的疾病的重要一步，因此，对治疗此类疾病的公共卫生问题有很大影响。拟议的研究将使用功能性磁共振成像来阐明MTL的功能，考虑到信息域对MTL组织的完整模型至关重要（目标1和2）。此外，是否关系编码和检索，被认为是海马功能的一个标志，延伸到情节事件的结合时间将被探讨（AIM 3）