Neurobiology of Binge-type Behavior

暴饮暴食行为的神经生物学

• 批准号: 8077862
• 负责人: REBECCA L CORWIN
• 金额: $ 34.37万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-12 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077862
• 关键词: Accounting; Address; Affect; Amygdaloid structure; Animal Model; Anterior; Anxiety; Behavior; Binge Eating; Binge eating disorder; Biological Neural Networks; Body Weight decreased; Bypass; Comorbidity; Consumption; Cues; Data; Development; Disease; Dopamine; Dopamine D1 Receptor; Dopamine D2 Receptor; Eating; Fatty acid glycerol esters; Feeding behaviors; Female; Food; Goals; Home environment; Hypothalamic structure; Impairment; Intake; Lateral; Learning; Lesion; Ligands; Macronutrients Nutrition; Maintenance; Maps; Medial; Midbrain structure; Modeling; Moods; Neurobiology; Nucleus Accumbens; Obesity; Obsessive compulsive behavior; Operative Surgical Procedures; Outcome; Prefrontal Cortex; Prevalence; Process; Prosencephalon; Rattus; Relapse; Reporting; Research; Review Literature; Signal Transduction; Site; Societies; Substance Use Disorder; Sucrose; Surveys; Testing; United States; Universities; Weight; Workplace; bariatric surgery; base; binge type behavior; cingulate cortex; clinically relevant; cost; dopaminergic neuron; effective therapy; experience; food consumption; human subject; male; meetings; preference; programs; public health relevance; receptor; response; social; sugar; treatment strategy

DESCRIPTION (provided by applicant): Binge eating is a form of compulsive food intake in which short-term homeostatic control of meal size is periodically and dramatically compromised. About 14 million people in the United States engage in binge eating. Binge relapse rates are high, treatment options are limited and the high co-morbidity with other disorders makes treatment a particular challenge. Understanding the factors that contribute to the transition from casual to compulsive binge-type consumption of food is critical for the development of new and effective treatment strategies. What accounts for the loss of control that occurs during these brief, but extremely large meals? Bingeing is characterized by the intermittent, excessive consumption of forbidden foods that are typically high in fat and sugar. Data from an animal model we have developed indicate that intermittent consumption, in-and-of itself, contributes to bingeing. While the effect of intermittency on palatable food intake has been well characterized in our model, the reason why intermittency enhances intake has not. Such information would have clinical relevance, since most people binge intermittently. We hypothesize that rats with intermittent access to optional palatable foods "learn to binge", and that this process involves an integrated neural network composed of forebrain targets of midbrain dopamine projections, as well as functional alterations in D1 and D2 receptor actions. Data collected over the past project period using our model support this scenario, and suggest that the behavior of our bingeing rats is more compulsive than that of control rats, and that the response to dopamine ligands, as well as the involvement of dopamine projection sites, differ between these groups. The results we have obtained map nicely onto findings reported in human subjects; therefore, we believe that our model provides a reasonable way to begin to clarify some of the factors that contribute to the development and maintenance of binge-type eating. The Aims of the proposed research are to: 1) determine specific components of intermittent access that promote binge eating (cue predictability, binge experience, macronutrient composition of the food), 2) identify forebrain regions that are critical to the development of binge eating, and 3) determine the contributions of dopamine D1- and D2-like receptors to the binge intake. Binge eating is a form of compulsive food intake in which short-term homeostatic control of meal size is periodically and dramatically compromised. About 14 million people in the United States engage in binge eating. Binge relapse rates are high, treatment options are limited and the high co-morbidity with other disorders makes treatment a particular challenge. Understanding the factors that contribute to the transition from casual to compulsive binge-type consumption of food is critical for the development of new and effective treatment strategies.

描述（由申请人提供）：暴饮暴食是一种强迫性食物摄入的形式，在这种情况下，膳食量的短期内稳态控制会周期性地受到严重影响。在美国，大约有1400万人参与暴饮暴食。狂欢复发率高，治疗选择有限，与其他疾病的高并发症使治疗成为一个特殊的挑战。了解导致从偶然到强迫暴饮暴食型食物消费转变的因素对于开发新的有效治疗策略至关重要。是什么原因导致了在这些短暂的，但非常大的饮食中发生的失控？暴饮暴食的特点是间歇性的，过量的食用被禁止的食物，这些食物通常含有高脂肪和糖。我们开发的动物模型的数据表明，间歇性消费本身就有助于暴饮暴食。虽然在我们的模型中已经很好地描述了不透明性对可口食物摄入的影响，但不透明性增加摄入的原因还没有。这些信息将具有临床意义，因为大多数人间歇性地暴饮暴食。我们假设，大鼠间歇性地获得可选的可口的食物“学习狂欢”，这个过程涉及到一个综合的神经网络组成的前脑目标中脑多巴胺的预测，以及功能改变D1和D2受体的行动。在过去的项目期间使用我们的模型收集的数据支持这种情况，并表明，我们的暴食大鼠的行为比对照组大鼠更强迫，并且对多巴胺配体的反应，以及多巴胺投射部位的参与，在这些组之间不同。我们获得的结果很好地映射到人类受试者中报告的发现;因此，我们相信我们的模型提供了一种合理的方法来开始澄清一些有助于发展和维持暴食型饮食的因素。拟议研究的目的是：1）确定促进暴饮暴食的间歇性接触的特定成分（线索可预测性，暴饮暴食经验，食物的常量营养素组成），2）确定对暴饮暴食发展至关重要的前脑区域，3）确定多巴胺D1和D2样受体对暴饮暴食的贡献。暴饮暴食是一种强迫性食物摄入的形式，在这种情况下，对膳食大小的短期内稳态控制会周期性地和戏剧性地受到损害。在美国，大约有1400万人参与暴饮暴食。狂欢复发率高，治疗选择有限，与其他疾病的高并发症使治疗成为一个特殊的挑战。了解导致从偶然到强迫暴饮暴食型食物消费转变的因素对于开发新的有效治疗策略至关重要。