Immunoglobulin germline genes, BCR repertoire development and disease susceptibility. An investigation of haplotypic variation between individuals

点击翻译按钮获取中文摘要

The immune system is capable of making a repertoire of protective antibodies including literally tens of millions of different specificities. These are produced by permutations and combinations of a small set of ‘germline’ genes. This project will analyse how individual variations in the germline genes lead to individual differences in the repertoires of available antibodies, and will investigate whether or not such differences contribute to our susceptibility to infection and autoimmune diseases.