Early Life Estrogenicity and Mammary Cancer Risk

生命早期雌激素和乳腺癌风险

• 批准号: 8180999
• 负责人: LEENA A. HILAKIVI-CLARKE
• 金额: $ 10.39万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-29 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8180999
• 关键词: Early; Life; Estrogenicity; Mammary; Cancer

Early Life Estrogenicity and Mammary Cancer Risk. While the timing of estrogen exposures has profound and often opposing effects on breast cancer suscepfibility, the molecular changes and programming that are altered by these exposures are almost entirely unknown. Dr. Hilakivi-Clarke and her team will focus on identifying key transcription factor-based signaling associated with increased mammary cancer risk in the mammary glands of rodents exposed to an elevated estrogenic environment in utero. We will determine the effects of these exposures on altering the sensitivity of the adult gland to E2, and on the endocrine responsiveness of mammary tumors arising in these glands. Data from these studies will be used to build computational models of ER-driven signaling associated with the effects of estrogens on increasing mammary gland susceptibility to neoplastic transformation and on endocrine responsiveness of mammary tumors. These data will also provide and unique powerful insights into the modeling in Projects 1 and 2.

生命早期雌激素形成与乳腺癌风险。而雌激素暴露的时间