B CELL MEMORY

B细胞记忆

• 批准号: 8172441
• 负责人: JOSHY JACOB
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172441
• 关键词: Antibodies; Antigen-Antibody Complex; Antigens; B-Lymphocytes; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Humoral Immunities; Immune response; Immune system; Immunologic Memory; Institution; Kinetics; Life; Memory; Memory B-Lymphocyte; Production; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; in vivo; pathogen; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Immunological memory is a hallmark of the vertebrate immune system. The first antigenic exposure leads to a slow and modest immune response while repeat exposure, even many years later, leads to a rapid and exaggerated response that is 2-3 orders of magnitude greater than the primary. In the case of humoral immunity, the increased efficacy of recall responses is due to the production of amplified levels of antigen-specific antibody, as well as the accelerated kinetics of their production. Current dogma suggests that this is due to selective activation of long-lived antigen-specific memory B cells. A downside of restricting secondary responses solely to memory cells is that the repertoire of the memory B cell pool remains static while pathogens continue to evolve. Here we are working to determine whether during secondary responses na¿ve, antigen-specific B cells participate alongside memory cells. We are showing that immune complexes formed in vivo between the antigen and pre-existing antibodies from the primary response, activate these naive B cells, inducing them to respond with accelerated kinetics and increased magnitude. The continued recruitment of new B cell clones following each antigenic exposure enables the immune system to stay abreast of rapidly changing pathogens.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 免疫记忆是脊椎动物免疫系统的标志。第一次抗原暴露导致缓慢和适度的免疫应答，而重复暴露，甚至多年后，导致快速和夸大的应答，其比初次大2-3个数量级。在体液免疫的情况下，回忆反应的功效增加是由于抗原特异性抗体的扩增水平的产生以及其产生的加速动力学。目前的理论认为，这是由于长寿命的抗原特异性记忆B细胞的选择性激活。 将次级反应仅限于记忆细胞的一个缺点是，当病原体继续进化时，记忆B细胞库的库保持静态。在这里，我们正在努力确定是否在次级反应幼稚，抗原特异性B细胞参与旁边的记忆细胞。 我们表明，抗原和来自初次应答的预先存在的抗体之间在体内形成的免疫复合物激活这些幼稚B细胞，诱导它们以加速的动力学和增加的幅度应答。在每次抗原暴露后，新的B细胞克隆的持续募集使免疫系统能够跟上快速变化的病原体。