B CELL MEMORY AND ORIGINAL ANTIGENIC SIN
B CELL MEMORY AND ORIGINAL ANTIGENIC SIN
批准号:
8357483
负责人:
JOSHY JACOB
金额:
$4.12万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-08-01 至 2012-04-30
关键词:
Activated LymphocyteAntigensB-LymphocytesData AnalysesFundingGrantHumanImmune responseImmunologyInfluenzaLifeLymphocyteMemoryMemory B-LymphocyteMusNational Center for Research ResourcesPrimatesPrincipal InvestigatorProliferatingResearchResearch InfrastructureResourcesSanguisorbaSchemeSourceT-LymphocyteUnited States National Institutes of HealthVaccinatedVaccine Researchcohortcostinfluenza virus vaccineinfluenzaviruspandemic influenzaresponsetheories
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Burnet's clonal selection theory, the reigning paradigm in immunology, dictates that antigen selects specific lymphocytes from a large repertoire of T and B cells and induces them to selectively proliferate. These activated lymphocytes facilitate rapid antigen clearance and, upon neutralization of the antigenic threat, they persist in the host as memory lymphocytes for a lifetime. Later in life, encounter with the same antigen induces massive proliferation of these memory lymphocytes and rapid clearance of the antigen. While this scheme holds true for most immune responses, the phenomenon of "original antigenic sin", first described in humans vaccinated against influenza virus, stands out as a paradox to Burnet's rules of B cell engagement (Fazekas de St and Webster, 1966a). This project seeks to understand B cell memory as it relates to original antigenic sin responses to both strains and subtypes of influenza virus. Since original antigenic sin can drastically dampen immune responses to newer strains of influenza it is critical to understand the fundamentals of this phenomenon as this has tremendous implications for influenza vaccine research particularly with pandemic influenza looming on the horizon. In order to investigate the mechanism of original antigenic sin we have immunized cohorts of mice with inactivated influenza viruses, and we continue to collect and analyze the data concerning their immune responses.
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专著(0)
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会议论文
Somatic hypermutation and rescue from self-reactivity in Pre-B lymphocytes
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批准号:10153689
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项目类别:
-
资助金额:$21.17万
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财政年份:2020
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8534701
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项目类别:
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资助金额:$48.19万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8704872
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项目类别:
-
资助金额:$47.85万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8899425
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项目类别:
-
资助金额:$65.98万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Negative regulation of Plasma cells by CD28 and B7 molecules
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批准号:8513589
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项目类别:
-
资助金额:$44.57万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:9114473
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项目类别:
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资助金额:$47.06万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
Overcoming maternal antibody-mediated immunosuppression
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批准号:8299339
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项目类别:
-
资助金额:$50.37万
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财政年份:2012
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负责人:JOSHY JACOB
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依托单位:
B CELL MEMORY
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批准号:8172441
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项目类别:
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资助金额:$5.48万
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财政年份:2010
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负责人:JOSHY JACOB
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依托单位:
B CELL MEMORY
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批准号:7958268
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项目类别:
-
资助金额:$5.67万
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财政年份:2009
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7958181
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项目类别:
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资助金额:$5.67万
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财政年份:2009
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负责人:JOSHY JACOB
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依托单位:
NOVEL VLP VACCINES FOR PANDEMIC INFLUENZA VIRUS
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批准号:7715818
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项目类别:
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资助金额:$2.85万
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财政年份:2008
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7715766
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项目类别:
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资助金额:$3.56万
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财政年份:2008
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负责人:JOSHY JACOB
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依托单位:
NOVEL VLP VACCINES FOR PANDEMIC INFLUENZA VIRUS
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批准号:7562687
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项目类别:
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资助金额:$3.16万
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财政年份:2007
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7562626
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项目类别:
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资助金额:$6.55万
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财政年份:2007
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负责人:JOSHY JACOB
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依托单位:
B LYMPHOCYTES, IMMUNOLOGIC MEMORY, CELLULAR IMMUNITY, TRANSGENIC ANIMAL
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批准号:7349295
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项目类别:
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资助金额:$4.01万
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财政年份:2006
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7349159
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项目类别:
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资助金额:$4.01万
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财政年份:2006
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:7165888
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项目类别:
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资助金额:$3.08万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
Enhancing HIV vaccine efficacy by blocking regulatory T cells
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批准号:7006383
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项目类别:
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资助金额:$25.35万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
Enhancing HIV vaccine efficacy by blocking regulatory T cells
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批准号:7140591
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项目类别:
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资助金额:$24.75万
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财政年份:2005
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负责人:JOSHY JACOB
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依托单位:
T CELL MEMORY
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批准号:6970959
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项目类别:
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资助金额:$3.44万
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财政年份:2004
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负责人:JOSHY JACOB
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依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
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批准号:2022J011295
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项目类别:省市级项目
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资助金额:10.0万元
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批准年份:2022
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负责人:王亚伟
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依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究
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批准号:30801055
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项目类别:青年科学基金项目
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资助金额:19.0万元
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批准年份:2008
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负责人:王丽梅
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依托单位: