WHITE MATTER DAMAGE IN AGE-RELATED COGNITIVE DECLINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项新项目的目标是测试与未受影响的患者相比，氧化应激、血管变化、认知变化和透明质酸代谢变化与血管认知障碍、阿尔茨海默病和其他认知障碍患者的相关性。该项目将重点研究这些患者脑组织中透明质酸代谢的特征变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this new project is to test how oxidative stress, vascular changes, cognitive changes and alterations in hyaluronan metabolism correlate in patients with vascular cognitive impairment, Alzheimer's disease, and other cognitive disorders compared to unaffected patients. This project will focus on chacterizing changes in hyaluronan metabolism in brain tissues from these patients.