GONADOTROPIN-RELEASING HORMONE ACTION

促性腺激素释放激素作用

• 批准号: 8173169
• 负责人: P. MICHAEL CONN
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173169
• 关键词: Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Disease; Enzymes; Frequencies; Funding; Gonadotropin Hormone Releasing Hormone; Grant; Institution; Ion Channel; Molecular Chaperones; Post-Translational Regulation; Proteins; Publishing; Regulation; Research; Research Personnel; Resources; Route; Signal Transduction; Source; Therapeutic; Therapeutic Agents; United States National Institutes of Health; analog; base; mutant; receptor; translational study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These are highly translational studies in which we have observed that the underlying basis of mutational disease is frequently the mis-routing of otherwise functional proteins, in this case a receptorbut other labs have now confirmed this for other receptors, ion channels and enzymes. We have shown that these mutant receptors can be rescued and restored to function by pharmacological chaperones. We have determined that the regulation of routing is also a normal type of post-translational regulation that occurs in routine cell function and can be controlled. During the prior period we have shown that misfolded hGnRHR can be refolded so that therapeutic agents need not be continuously present. We have also shown that control of hGnRHR helps explain the basics of the ability of this receptor to respond to both amplitude and frequency modulated signals. GnRHR analogs were screened for potential therapeutic action and a review was published.

这个子项目是众多研究子项目之一