HIGH THROUGHPUT SCREENING ASSAY DEVELOPMENT FOR PHARMACOPERONES

制药公司的高通量筛选检测方法开发

基本信息

  • 批准号:
    8357845
  • 负责人:
  • 金额:
    $ 5.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The specific aim is to produce and validate screens for identification of pharmacoperone drugs from molecular libraries which exert their actions by a newly appreciated therapeutic approachnamely, control of post-translational protein folding and, as a consequence, cellular trafficking and rescue of mutated proteins. G protein coupled receptors (GPCRs) are frequently targeted in library screening, yet this approach generally relies on screens that identify agonists or antagonists and would have missed many of the drugs that will be identified in the proposed screens. Our approach identifies drugs with a significant degree of novelty in therapeutic approach, relying on cellular mechanisms that are not currently represented in the Molecular Libraries assay pipeline; this offers an untapped opportunity for use of the HTS approach.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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P. MICHAEL CONN其他文献

P. MICHAEL CONN的其他文献

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{{ truncateString('P. MICHAEL CONN', 18)}}的其他基金

Mouse Model for Diseases of Protein Misfolding
蛋白质错误折叠疾病的小鼠模型
  • 批准号:
    8805919
  • 财政年份:
    2014
  • 资助金额:
    $ 5.82万
  • 项目类别:
High Throughput Screening for Pharmacoperones of the V2 Receptor
V2 受体药用酮的高通量筛选
  • 批准号:
    8696856
  • 财政年份:
    2013
  • 资助金额:
    $ 5.82万
  • 项目类别:
High Throughput Screening for Pharmacoperones of the V2 Receptor
V2 受体药用酮的高通量筛选
  • 批准号:
    8555110
  • 财政年份:
    2013
  • 资助金额:
    $ 5.82万
  • 项目类别:
High Throughput Screening for Pharmacoperones of the V2 Receptor
V2 受体药用酮的高通量筛选
  • 批准号:
    8816998
  • 财政年份:
    2013
  • 资助金额:
    $ 5.82万
  • 项目类别:
Mouse Model for Diseases of Protein Misfolding
蛋白质错误折叠疾病的小鼠模型
  • 批准号:
    8208973
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
蛋白质错误折叠疾病的小鼠模型
  • 批准号:
    8357844
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
Mouse Model for Diseases of Protein Misfolding
蛋白质错误折叠疾病的小鼠模型
  • 批准号:
    8033595
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
GONADOTROPIN-RELEASING HORMONE ACTION
促性腺激素释放激素作用
  • 批准号:
    8357723
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
High Throughput Screening Assay Development for Pharmacoperones
药用酮的高通量筛选试验开发
  • 批准号:
    8259448
  • 财政年份:
    2010
  • 资助金额:
    $ 5.82万
  • 项目类别:
GONADOTROPIN-RELEASING HORMONE ACTION
促性腺激素释放激素作用
  • 批准号:
    8173169
  • 财政年份:
    2010
  • 资助金额:
    $ 5.82万
  • 项目类别:

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