EFFECTS OF REVERSIBLE INACTIVATION ON MEMORY AND BRAIN FUNCTIONAL ACTIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 内侧颞叶在记忆中的作用已经在动物和人类中进行了广泛的侵入性研究，使用神经成像技术。然而，如果能够应用类似的技术来验证与行为相关的神经活动，人类和动物研究之间的联系将得到加强。此外，只有在直接操纵函数的情况下，才能得出因果结论。我们建议结合功能磁共振成像和可逆灭活技术来研究海马体在清醒、行为的恒河猴记忆中的作用。该项目启动了一系列研究，将使用功能磁共振成像(FMRI)来阐明非人类灵长类动物记忆处理的神经基础，并使用新奇反应范式来解释清醒行为猴子的海马体暂时失活。通过评估短暂“脱机”特定神经结构的影响，这些技术的结合将提供对内侧颞叶正常功能的洞察，而这些功能是仅使用永久性病变或功能磁共振成像研究无法获得的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The medial temporal lobe's role in memory has been extensively studied invasively in animals, and in humans using neuroimaging. However, the link between human and animal studies would be strengthened if similar techniques can be applied to verify the neural activity associated with behavior. Furthermore, only in directly manipulating function can causative conclusions be made. We propose to combine functional MRI and reversible inactivation techniques to study the roles of the hippocampus in memory in awake, behaving rhesus macaques. This project initiates a line of research that will elucidate the neural basis of mnemonic processing in nonhuman primates using functional magnetic resonance imaging (fMRI) and temporary inactivation of the hippocampus in awake behaving monkeys using a novelty response paradigm. By permitting assessment of the effects of briefly taking particular neural structures "offline" the combination of these techniques will provide insights into the normal function of the medial temporal lobes that cannot be obtained from studies using permanent lesions or fMRI alone.