Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
基本信息
- 批准号:10831114
- 负责人:
- 金额:$ 17.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Project Summary
General anesthetics may act as neurotoxins in the developing mammalian nervous system and cause long-term
neurobehavioral changes after exposure in infancy. Repeated exposure is particularly deleterious to the
developing nervous system, and children who undergo more than one general anesthesia before the age of 4
are at an increased risk for substantial emotional and cognitive changes. It is therefore critical that preventative
treatments be found. Studies in animal models have suggested that persistent anesthetic-induced changes such
as neurotoxicity, gliotoxicity, loss of synapses and changes in mitochondrial structure may lead to long-term
behavioral impairments. Early effects of anesthesia on mitochondria may be key to long-term impairments:
protection of mitochondria from oxidative stress caused by free radical generation from general anesthetics
eliminates subsequent cognitive impairment in adulthood in rodents. We have established a nonhuman primate
model of early anesthetic exposure. In a previous award, we showed that infant rhesus monkeys that received
multiple exposures of to the inhalation anesthetic sevoflurane, commonly used in pediatric anesthesia, showed
long-term changes in socioemotional and cognitive development when tested later in development. In this new
proposal, we will use that model to test the hypothesis that neonatal anesthesia exposure is associated with
long-term changes in synaptic and mitochondrial structure in the primate brain, and that protection of
mitochondria from oxidative stress at the time of anesthesia exposure mitigates or prevents subsequent changes
in cognitive and socioemotional development. Specifically, in Aim 1 of this project, mitochondrial and synaptic
structure in adulthood will be examined at the electron microscopic level in tissue prepared and banked from
those subjects from the previous award. For Aim 2, infant rhesus macaques will be exposed to sevoflurane (3
exposures in the six weeks of life) in the presence of R(+)pramipexole, a mitochondrial protectant, or treated
with vehicle and will be followed behaviorally for 2 years to assess sparing of neurobehavioral changes in the
treated group. We will determine whether R(+)pramipexole treatment also protects against synaptic and
mitochondrial changes in these monkeys. Together, results from these studies can provide a causal link between
anesthetic exposure, mitochondrial dysfunction, and altered emotional and cognitive behavior in monkeys. They
will also provide a first step towards improved anesthetic protocols and preventative treatments that will allow
children to undergo safe surgery while minimizing unintended long-term effects on the brain and behavior.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARIA C ALVARADO其他文献
MARIA C ALVARADO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARIA C ALVARADO', 18)}}的其他基金
The role of stress exposure on estradiol-induced changes in neuroinflammation and cognition
压力暴露对雌二醇引起的神经炎症和认知变化的作用
- 批准号:
10501914 - 财政年份:2022
- 资助金额:
$ 17.76万 - 项目类别:
The role of stress exposure on estradiol-induced changes in neuroinflammation and cognition
压力暴露对雌二醇引起的神经炎症和认知变化的作用
- 批准号:
10686940 - 财政年份:2022
- 资助金额:
$ 17.76万 - 项目类别:
Early risk factors of accelerated neural aging trajectories and cognitive decline: a nonhuman primate longitudinal model
加速神经老化轨迹和认知能力下降的早期危险因素:非人类灵长类动物纵向模型
- 批准号:
10458748 - 财政年份:2021
- 资助金额:
$ 17.76万 - 项目类别:
Early risk factors of accelerated neural aging trajectories and cognitive decline: a nonhuman primate longitudinal model
加速神经老化轨迹和认知能力下降的早期危险因素:非人类灵长类动物纵向模型
- 批准号:
10615795 - 财政年份:2021
- 资助金额:
$ 17.76万 - 项目类别:
Early risk factors of accelerated neural aging trajectories and cognitive decline: a nonhuman primate longitudinal model
加速神经老化轨迹和认知能力下降的早期危险因素:非人类灵长类动物纵向模型
- 批准号:
10306164 - 财政年份:2021
- 资助金额:
$ 17.76万 - 项目类别:
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10400934 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10170393 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10622468 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Development of Hippocampal-Prefrontal Interactions in Adolescence
青春期海马-前额叶相互作用的发展
- 批准号:
9382631 - 财政年份:2017
- 资助金额:
$ 17.76万 - 项目类别:
Development of Hippocampal-Prefrontal Interactions in Adolescence
青春期海马-前额叶相互作用的发展
- 批准号:
10194565 - 财政年份:2017
- 资助金额:
$ 17.76万 - 项目类别:
相似海外基金
Basic research for the development of skin protection materials that can visualize indigenous skin bacteria to prevent CRBSI
开发可可视化本地皮肤细菌以预防 CRBSI 的皮肤保护材料的基础研究
- 批准号:
23K09814 - 财政年份:2023
- 资助金额:
$ 17.76万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10400934 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10170393 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia
线粒体保护以防止产后麻醉后神经行为的变化
- 批准号:
10622468 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Application Title: Development of a working prototype of a tokenised data-security system that keeps tokenised data at rest secure when executing queries and searches to prevent fraud and give protection against cyber attacks
申请标题:开发代币化数据安全系统的工作原型,该系统在执行查询和搜索时保持静态代币化数据的安全,以防止欺诈并提供针对网络攻击的保护
- 批准号:
88375 - 财政年份:2020
- 资助金额:
$ 17.76万 - 项目类别:
Collaborative R&D
Biometric Information Protection Utilization Infrastructure to Ensure Personal Convenience and Prevent Identity Theft
生物识别信息保护利用基础设施确保个人便利并防止身份盗用
- 批准号:
18H04120 - 财政年份:2018
- 资助金额:
$ 17.76万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
A real-time, cost-effective, accurate UV measurement and sun protection system to prevent and reduce the incidence of sunburn in high-risk consumers.
实时、经济高效、准确的紫外线测量和防晒系统,可预防和减少高风险消费者晒伤的发生率。
- 批准号:
9465064 - 财政年份:2017
- 资助金额:
$ 17.76万 - 项目类别:
Development of a protection method to prevent spinal cord ischemia by promoting spinal collateral circulation with proangiogenic cytokine-inducer.
开发一种通过促血管生成细胞因子诱导剂促进脊髓侧支循环来预防脊髓缺血的保护方法。
- 批准号:
15K10243 - 财政年份:2015
- 资助金额:
$ 17.76万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
New candidate vaccines to prevent tuberculosis: preclinical assessment of efficacy, safety and mechanism of protection
预防结核病的新候选疫苗:功效、安全性和保护机制的临床前评估
- 批准号:
nhmrc : 1043519 - 财政年份:2013
- 资助金额:
$ 17.76万 - 项目类别:
Project Grants
Engine Overspeed Protection Device to Prevent Engine Overspeed during Engine Start Procedure on Certain Types of Helicopter.
发动机超速保护装置,用于防止某些类型的直升机在发动机启动过程中发动机超速。
- 批准号:
700069 - 财政年份:2011
- 资助金额:
$ 17.76万 - 项目类别:
GRD Proof of Market