Conversion agricultural waste to nanomedicine for bone regeneration

将农业废物转化为纳米药物以促进骨再生

• 批准号: 571664-2021
• 负责人: Tan, BoB
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=743233
• 关键词: Conversion; agricultural; waste; nanomedicine; bone

Growing geriatric patient populations around the globe are leading to increased osteoporosis-related fractures. In North America one in two over age 50 is anticipated to be at risk of developing hip osteoporosis mostly due to aging and the prevalence of osteoporosis, which will likely accelerate demand for bone implants. Although research progress has been made in recent times, orthopedic implants have a limited lifespan and often fail due to low osseointegration. Hence it is essential to facilitate osseointegration in implants by enhancing the ability of osteogenesis. It is believed that nanostructures have the breakthrough potential to propel the field of bone regeneration. The applicant's research team specializes in developing nanomaterial fabrication using high repetition rate femtosecond lasers. The team has successfully synthesized three-dimensional nanostructure from rice husk/straw and eggshells. In this project, they will collaborate with faculty from University of Wisconsin at Milwaukee (UWM) to explore the feasibility of applying the nanostructure as medicine for bone regeneration. While the team at Ryerson develops the fabrication strategy to tune the physiochemical and biological properties of the nanostructure, the team at UWM will study the biocompatibility of the innovative nanomaterial, their interaction strategies with mesenchymal cells, and immune response to the nanomaterial when implanted in body. The long-term goal of this collaboration is to develop a technique to convert agricultural waste to a highly beneficial medical invention. This research is beneficial to Canada in health care, environmental, economic, and social contexts.

全球老年患者数量的不断增长导致骨质疏松症相关骨折的增加。在北美，50 岁以上的人预计有二分之一面临患髋部骨质疏松症的风险，这主要是由于老龄化和骨质疏松症的流行，这可能会增加对骨植入物的需求。尽管近年来研究取得了进展，但骨科植入物的使用寿命有限，并且经常因骨整合低而失败。因此，通过增强成骨能力来促进种植体的骨整合至关重要。人们相信纳米结构具有推动骨再生领域的突破性潜力。申请人的研究团队专门开发使用高重复率飞秒激光器的纳米材料制造。该团队成功利用稻壳/秸秆和蛋壳合成了三维纳米结构。在这个项目中，他们将与威斯康星大学密尔沃基分校（UWM）的教师合作，探索将纳米结构用作骨再生药物的可行性。 在瑞尔森大学的团队开发制造策略来调整纳米结构的物理化学和生物特性的同时，华盛顿大学的团队将研究创新纳米材料的生物相容性、它们与间充质细胞的相互作用策略，以及植入体内时对纳米材料的免疫反应。此次合作的长期目标是开发一种将农业废物转化为高度有益的医疗发明的技术。这项研究对加拿大的医疗保健、环境、经济和社会领域有益。