Conversion agricultural waste to nanomedicine for bone regeneration

随着地球仪老年患者数量的增加，骨质疏松相关骨折的发生率也在增加。在北美，预计50岁以上的人中有两分之一有患髋关节骨质疏松症的风险，主要是由于衰老和骨质疏松症的流行，这可能会加速对骨植入物的需求。虽然最近取得了研究进展，但骨科植入物的使用寿命有限，并且经常由于骨整合率低而失败。因此，通过增强成骨能力来促进种植体的骨整合是至关重要的。人们认为，纳米结构具有突破性的潜力，推动骨再生领域。申请人的研究团队专门开发使用高重复率飞秒激光的纳米材料制造。该团队已经成功地从稻壳/稻草和蛋壳中合成了三维纳米结构。在这个项目中，他们将与密尔沃基的威斯康星州大学（UWM）的教师合作，探索将纳米结构用作骨再生药物的可行性。 虽然Ryerson的团队开发了制造策略来调整纳米结构的理化和生物学特性，但UWM的团队将研究创新纳米材料的生物相容性，它们与间充质细胞的相互作用策略，以及植入体内时对纳米材料的免疫反应。这项合作的长期目标是开发一种将农业废物转化为高度有益的医疗发明的技术。这项研究对加拿大的医疗保健，环境，经济和社会背景都是有益的。

Growing geriatric patient populations around the globe are leading to increased osteoporosis-related fractures. In North America one in two over age 50 is anticipated to be at risk of developing hip osteoporosis mostly due to aging and the prevalence of osteoporosis, which will likely accelerate demand for bone implants. Although research progress has been made in recent times, orthopedic implants have a limited lifespan and often fail due to low osseointegration. Hence it is essential to facilitate osseointegration in implants by enhancing the ability of osteogenesis. It is believed that nanostructures have the breakthrough potential to propel the field of bone regeneration. The applicant's research team specializes in developing nanomaterial fabrication using high repetition rate femtosecond lasers. The team has successfully synthesized three-dimensional nanostructure from rice husk/straw and eggshells. In this project, they will collaborate with faculty from University of Wisconsin at Milwaukee (UWM) to explore the feasibility of applying the nanostructure as medicine for bone regeneration. While the team at Ryerson develops the fabrication strategy to tune the physiochemical and biological properties of the nanostructure, the team at UWM will study the biocompatibility of the innovative nanomaterial, their interaction strategies with mesenchymal cells, and immune response to the nanomaterial when implanted in body. The long-term goal of this collaboration is to develop a technique to convert agricultural waste to a highly beneficial medical invention. This research is beneficial to Canada in health care, environmental, economic, and social contexts.