2/2-Computer-Assisted Cognitive-Behavior Therapy for Depression
2/2-计算机辅助抑郁症认知行为疗法
基本信息
- 批准号:8091370
- 负责人:
- 金额:$ 29.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-16 至 2014-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAttitudeCharacteristicsClinicalCognitiveCognitive TherapyComputer AssistedComputer-Assisted TherapyControl GroupsDSM-IVDataData AnalysesDevelopmentDisease remissionElementsFemaleGrantHealth Care CostsHourIndividualInterventionInvestigationKnowledgeMajor Depressive DisorderMeasuresMental DepressionMethodsModelingMultimediaOutcomeOutpatientsPatient PreferencesPatientsPennsylvaniaPhaseProtocols documentationPsychotherapyPublic HealthQuality of lifeRandomizedRandomized Controlled TrialsRecruitment ActivityRelapseResearchResearch DesignResearch MethodologySamplingServicesSiteSocial FunctioningStagingTestingTherapeuticThinkingTimeTrainingTreatment outcomeUniversitiesWaiting Listsbasebehavior changeclinically significantcomparative efficacyconventional therapycostcost effectivecost effectivenessdepressive symptomsdesigneffective therapyefficacy testingexperiencefollow-uphealth care service utilizationimprovedmalemeetingsprogramspublic health relevanceresponse
项目摘要
DESCRIPTION (provided by applicant): We propose a two center, randomized controlled trial evaluating the efficacy and cost-effectiveness of computer-assisted cognitive-behavior therapy (CCBT) for outpatients with major depressive disorder (MDD). Results of a preliminary study indicated that, despite reducing the amount of therapist contact by about 50%, CCBT was at least as effective as an 8 week course of conventional individual CBT on depression outcomes, with greater effects on dysfunctional attitudes and knowledge about CBT. We now propose to conduct a more rigorous test of the therapeutic equivalence and cost-effectiveness of CCBT versus a full 16 week, 20 session course of individual CBT, which provides three times the amount of therapeutic contact. A total of 172 male and female outpatients (86 per site) meeting SCID/DSM-IV criteria for MDD will be randomized across five years. Outcomes will be assessed by independent evaluators without knowledge of the treatment received. The study is designed to have the statistical power to test the equivalence of CCBT and the full course of CBT at both the end of acute phase therapy and across 6 months of follow-up. In addition to effects on depressive symptoms and categorical outcomes (i.e., response and remission rates), dependent variables will include measures of dysfunctional attitudes, social functioning, quality of life, and health care costs and utilization. It is predicted that: 1) CCBT will be equivalent to CBT at week 16 and across the 6 month follow-up; and 2) CCBT will be significantly more cost-effective than CBT. Secondary aims include testing potential moderators of treatment outcome and the predicted absence of site differences (as an indicator of disseminability). This trial has significant implications for the public health because it will provide a rigorous test the clinical utility of CCBT against a model of conventional individual therapy that offers three times as much clinical contact. If equivalence and cost- effectiveness are demonstrated, the proposed research will set the stage for larger scale studies evaluating broader dissemination of CCBT.
PUBLIC HEALTH RELEVANCE: Although Cognitive Behavior Therapy (CBT) is an effective treatment for major depressive disorder, its utility is limited by cost and availability of trained therapists. Computer-assisted delivery of this therapy (CCBT) has shown promise and may offer similar benefits as CBT with as little as one third the amount of therapist time. The proposed study will test the therapeutic equivalence and cost-effectiveness of CCBT versus CBT across a 16 week acute phase and a 6 month follow-up.
描述(由申请人提供):我们提出了一个两个中心,随机对照试验,评估计算机辅助认知行为治疗(CCBT)的有效性和成本效益的门诊患者与重性抑郁症(MDD)。一项初步研究的结果表明,尽管减少了约50%的治疗师接触量,CCBT至少与为期8周的常规个人CBT课程一样有效,对抑郁症的结果有更大的影响,对CBT的功能失调态度和知识有更大的影响。我们现在建议进行更严格的治疗等效性和成本效益的测试CCBT与一个完整的16周,20个疗程的个人CBT,它提供了三倍的治疗接触。将在5年内对符合MDD的SCID/DSM-IV标准的共172例男性和女性门诊患者(每个研究中心86例)进行随机分组。结局将由不了解所接受治疗的独立评价者进行评估。本研究旨在具有统计学把握度,以检验CCBT和CBT全疗程在急性期治疗结束时和6个月随访期间的等效性。除了对抑郁症状和分类结果的影响(即,反应和缓解率),因变量将包括功能失调的态度,社会功能,生活质量和卫生保健费用和利用的措施。据预测:1)CCBT在第16周和6个月随访期间与CBT相当; 2)CCBT的成本效益明显高于CBT。次要目的包括测试治疗结果的潜在调节因素和预测的不存在部位差异(作为传播性的指标)。这项试验对公众健康具有重大意义,因为它将提供一个严格的测试CCBT的临床效用与传统的个体治疗模式,提供三倍的临床接触。如果等效性和成本效益得到证明,拟议的研究将为评估CCBT更广泛传播的更大规模研究奠定基础。
公共卫生相关性:虽然认知行为疗法(CBT)是一种有效的治疗抑郁症,其效用是有限的成本和训练有素的治疗师。计算机辅助提供这种治疗(CCBT)已显示出希望,并可能提供与CBT类似的好处,只需治疗师时间的三分之一。拟议的研究将在16周急性期和6个月随访期间测试CCBT与CBT的治疗等效性和成本效益。
项目成果
期刊论文数量(0)
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Jesse H. Wright其他文献
Combining Cognitive Therapy and Pharmacotherapy for Schizophrenia
认知疗法与药物疗法相结合治疗精神分裂症
- DOI:
10.1891/088983907780493278 - 发表时间:
2007 - 期刊:
- 影响因子:0.7
- 作者:
D. Kingdon;S. Rathod;L. Hansen;F. Naeem;Jesse H. Wright - 通讯作者:
Jesse H. Wright
Cognitive therapy with inpatients.
对住院患者进行认知治疗。
- DOI:
10.1016/s0163-8343(96)00122-3 - 发表时间:
1997 - 期刊:
- 影响因子:7
- 作者:
S. Stuart;Jesse H. Wright;M. Thase;A. Beck - 通讯作者:
A. Beck
Combining Cognitive Therapy and Medication for Mood Disorders
结合认知疗法和药物治疗情绪障碍
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
E. Friedman;Jesse H. Wright;R. Jarrett;M. Thase - 通讯作者:
M. Thase
Computer-Assisted CBT and Mobile Apps for Depression: Assessment and Integration Into Clinical Care.
计算机辅助 CBT 和移动应用程序治疗抑郁症:评估和整合到临床护理中。
- DOI:
10.1176/appi.focus.20190044 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Jesse H. Wright;M. Mishkind - 通讯作者:
M. Mishkind
Improving Efficiency of Psychotherapy for Depression: Computer-assisted Cognitive-behavior Therapy Versus Standard Cognitive-behavior Therapy
提高抑郁症心理治疗的效率:计算机辅助认知行为疗法与标准认知行为疗法
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
M. Thase;Jesse H. Wright;T. Eells;M. Barrett;S. Wisniewski;G. Balasubramani;Paul;McCrone;Gregory K Brown - 通讯作者:
Gregory K Brown
Jesse H. Wright的其他文献
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{{ truncateString('Jesse H. Wright', 18)}}的其他基金
Dissemination of Computer-assisted Cognitive-behavior Therapy for Depression in Primary Care
初级保健中抑郁症计算机辅助认知行为疗法的传播
- 批准号:
8934425 - 财政年份:2015
- 资助金额:
$ 29.43万 - 项目类别:
2/2-Computer-Assisted Cognitive-Behavior Therapy for Depression
2/2-计算机辅助抑郁症认知行为疗法
- 批准号:
8427392 - 财政年份:2010
- 资助金额:
$ 29.43万 - 项目类别:
2/2-Computer-Assisted Cognitive-Behavior Therapy for Depression
2/2-计算机辅助抑郁症认知行为疗法
- 批准号:
7883842 - 财政年份:2010
- 资助金额:
$ 29.43万 - 项目类别:
2/2-Computer-Assisted Cognitive-Behavior Therapy for Depression
2/2-计算机辅助抑郁症认知行为疗法
- 批准号:
8235049 - 财政年份:2010
- 资助金额:
$ 29.43万 - 项目类别:
DVD-ROM FOR COMPUTER-ASSISTED COGNITIVE THERAPY
用于计算机辅助认知治疗的 DVD-ROM
- 批准号:
8413206 - 财政年份:2000
- 资助金额:
$ 29.43万 - 项目类别:
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