Research Methods Core

研究方法核心

• 批准号: 8119603
• 负责人: MICHAEL JOSEPH OWENS
• 金额: $ 24.15万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119603
• 关键词: Antidepressive Agents; Arts; Biochemical Genetics; Biological Assay; C-reactive protein; Candidate Disease Gene; Data; Development; Enrollment; Ethnic group; Genetic; Genetic Polymorphism; Interleukin-6; Laboratories; Linkage Disequilibrium; Maps; Modality; Research Methodology; Research Personnel; Statistical Models; Testing; data management; genetic analysis; hypothalamic-pituitary-adrenal axis; response

The purpose of this Core is to provide a common set of state-of-the-art biochemical and genetic analyses to CIDAR researchers relevant to testing various hypotheses related to prediction of antidepressant response. The laboratories of the Core will provide assessments of hypothalamic-pituitary-adrenal (HPA) axis function, interleukin-6 and C-reactive protein (C-RP), antidepressant drug concentrations, and detailed genetic analyses. The latter includes fine mapping of candidate genes, choosing "tagging SNPs" as well as genetic data management. Particular emphasis will be placed on development of a dense polymorphism map for each candidate gene to identify the degree of linkage disequilibrium in different ethnic groups. These data will be provided to the statistical modeling core. Having these determinations performed by a central facility using a common set of high quality assay modalities will provide consistency across all of the subjects enrolled in this 5 year study.

该核心的目的是提供一套通用的最先进的生化和 CIDAR研究人员进行遗传分析，以测试与以下相关的各种假设： 预测抗抑郁反应。核心实验室将提供以下评估： 下丘脑-垂体-肾上腺（HPA）轴功能，白细胞介素-6和C反应蛋白（C-RP）， 抗抑郁药物浓度和详细的遗传分析。后者包括罚款 候选基因的定位，选择“标记SNP”以及遗传数据管理。 特别强调的是，为每一个基因组建立一个密集的多态性图谱。 候选基因，以确定不同种族群体中连锁不平衡的程度。这些 将向统计建模核心提供数据。这些决定由一个 使用一组通用的高质量检测模式的中心设施将在 所有参与这项为期5年的研究的受试者。