Neurocircuitry underlying effectiveness of DBS in OCD

本项目将重点研究清醒行为中涉及回避和奖励行为的回路。 灵长类动物。灵长类动物是这个项目中的关键一环，因为它们很聪明，可以接受训练 模拟人类行为的复杂任务，感兴趣区域之间的同源性在 灵长类动物和人类，有相当多的解剖学信息涉及到 调节奖赏和回避，并在强迫症(OCD)中调用。这些地区 包括腹内侧前额叶皮质(VmPFC)、眶前叶皮质(OFC)、前背侧 扣带回皮质(DACC)和腹侧纹状体(VS)。有相当多的关于电路的数据 啮齿动物对灭绝的恐惧。特别是，下丘脑(IL)和边缘前区(PL)似乎有一个 在调节恐惧消退(Quirk)中的相互作用。虽然确切的同源性尚不清楚，但一个 合理的假设是，IL对应于vmPFC，而PL区对应于dACC。在……里面 相比之下，在灵长类动物身上研究这些区域的工作相对较少。这件事的首要目标是 该项目旨在弥合啮齿动物和灵长类动物之间的差距，这将提供一个重要的框架 为合理制定旨在治疗人类疾病的星展银行战略。 相关性(请参阅说明)： 强迫症(OCD)是一种慢性精神疾病，影响全球2%-3%的人 人口。这就是疾病是十大康复疾病之一。这项研究将检查神经 与强迫症相关的行为的网络和机制。这些行为不仅限于 强迫症，但与一系列情感和成瘾障碍有关。集体建议的研究 将产生新的假说，即这些大脑网络中的功能障碍是如何通过 并提供对正常行为反应背后的机制的洞察。

This project will focus on studying the circuitry involved in avoidance and reward behavior in awake-behaving primates. Primates are a critical link in this project because they are intelligent and can be trained to perform complex tasks that mimic human behaviors, the homology between areas of interest is fairiy close between primates and humans, and there is a considerable anatomic information regarding areas involved in mediating reward and avoidance, and invoked in obsessive-compulsive disorder (OCD). These areas include the ventro-medial prefrontal cortex (vmPFC), the orbitofrontal cortex (OFC), the anterior dorsal cingulate cortex (dACC) and the ventral striatum (VS). There is considerable data regarding the circuitry of fear extinction in rodents. In particular, the infralimic (IL) and pre-limbic (PL) areas appear to have a reciprocal role in the mediating fear extinction (Quirk). Although the exact homology is not clear, a reasonable hypothesis is that IL corresponds to the vmPFC and that area PL corresponds to the dACC. In contrast, there has been relatively little work studying these areas in primates. The overarching goal of this project is to bridge the gap between rodents and primates, which will then provide an important framework for the rational development of DBS strategies aimed at treating human disorders. RELEVANCE (See instructions): Obsessive Compulsive Disorder (OCD) is a chronic psychiatric illness that affects 2-3% of the woridwide population. This is disease is in the top ten dehabilitating diseases. This study will examine the neural network and mechanisms that underiie behaviors associated with OCD. These behaviors not limited to OCD, but are associated with a range of affective and addictive disorders. The collective proposed studies will generate new hypotheses of how dysfunctions within these brain networks are expressed across diseases and provide insight into the mechanisms underiying normal behavioral responses.