NEURAL BASES OF EMOTION REGULATION AND DYSREGULATION IN ADOLESCENCE

青春期情绪调节和失调的神经基础

• 批准号: 8076863
• 负责人: Richard J Davidson
• 金额: $ 28.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076863
• 关键词: 14 year old; 15 year old; 16 year old; 2 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Amygdaloid structure; Anger; Anxiety; Behavioral; Biological; Brain; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Dizygotic Twins; Emotional; Exhibits; Eye; Face; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Hydrocortisone; Image; Individual; Individual Differences; Inferior frontal gyrus; Instruction; Life; Magnetic Resonance Imaging; Measures; Mood Disorders; Participant; Pattern; Peripheral; Phase; Physiological; Prefrontal Cortex; Process; Risk; Role; Sampling; Scanning; Short-Term Memory; Structure; Symptoms; Testing; Twin Multiple Birth; base; cognitive control; cohort; comparison group; design; early adolescence; emotion regulation; falls; follow-up; indexing; meetings; member; novel; relating to nervous system; response; showing emotion; social

This project will examine the neural bases of emotion regulation and dysregulation in samples of adolescents selected on the basis of their risk status for internalizing disorder. Adolescent is a period during which risk for anxiety and mood disorders increases substantially and little is known about the brain mechanisms responsible for vulnerability to these disorders. We will take advantage of extensive data collected within two longitudinal cohorts that will be a central feature of this Center. From these cohorts, three samples will be tested. One sample consists of 85 individuals from Project 2 who underwent fMRI scanning using virtually the identical tasks when they were 14 years of age. A second sample, also derived from Project 2 (Essex), will include participants who will be selected to vary in levels of basal cortisol early in life (age 4.5 years) and later in early adolescence. In another cohort derived from Project 3 (Goldsmith) monozygotic and dizygotic twin pairs will be selected in which one member of the pair has high levels of internalizing symptoms. Both concordant and discordant pairs will be selected in this manner. All participants will undergo a scanning session during which functional MRI will be obtained while participants engage in two tasks. One task will assess the neural correlates of both voluntary and automatic emotion regulation while the other task will be a face go-no-go task that assesses sensitivity to different facial expressions of emotion and inhibitory control in the face of emotional distracters. During scanning, electrodermal and pupillary measures will be obtained, in addition to eye tracking. In addition, participants will be administered an automated version of a task designed to assess working memory capacity (O-span) to ascertain the relation between individual differences in working memory capacity and emotion regulation. We will test the hypothesis that adolescents selected to be vulnerability to internalizing disorders (either because of cortisol profiles or symptoms of anxiety) will exhibit evidence of the poor emotion regulation expressed as high levels of amygdala activation and low levels of activation in ventromedial prefrontal cortex during instructions to down-regulate negative affect. A similar pattern is expected during the task phase designed to assess automatic emotion regulation. The face go-no-go task will allow us to test the hypothesis that adolescents at increased risk for internalizing disorders will show increased sensitivity to fear and angry faces and show a more conservative response bias (inhibiting their response to faces other than the target); moreover these individuals are predicted to show increased activation in the right inferior frontal gyrus, a region in which we have previously found to correlated with social anxiety. The findings from this project will provide novel new evidence on the neural bases of emotion regulation and dysregulation in adolescence and will showcase the role of these processes in vulnerability to anxiety and mood disorders.

该项目将在青少年样本中检验情绪调节和调节失调的神经基础。 根据他们内在化障碍的风险状况进行选择。青春期是指有风险的时期 因为焦虑和情绪障碍显著增加，对大脑机制知之甚少 对这些疾病的脆弱性负有责任。我们将利用在 两个纵向队列将成为该中心的中心特征。从这些队列中，有三个样本将 接受测试。一个样本由来自项目2的85名个体组成，他们接受了使用 当他们14岁的时候，他们的任务几乎是相同的。第二个样本，也来自项目2 (埃塞克斯)，将包括将被选为在生命早期(4.5岁)基础皮质醇水平不同的参与者 几年)，然后是青春期早期。在来自项目3(Goldsmith)的另一个队列中，单合子和 将选择双卵双胞胎，其中一人内化水平较高 症状。协调和不协调对都将以这种方式选择。所有参与者将 接受一次扫描，在此期间将获得功能性磁共振成像，而参与者将进行两次 任务。一项任务将评估自愿和自动情绪调节的神经关联，而 另一项任务将是面孔去不去任务，它评估对不同面部表情的敏感度 以及面对情绪干扰时的抑制性控制。扫描过程中，电真皮和瞳孔 除了眼睛跟踪之外，还将获得措施。此外，参与者将被管理一个 自动版本的任务，旨在评估工作记忆容量(O-SPAN)以确定两者之间的关系 工作记忆容量和情绪调节的个体差异。我们将测试 认为青少年容易患内化性障碍的假说(要么是因为皮质醇 焦虑的简档或症状)将显示情绪调节不良的证据，表示为高 指令时杏仁核激活水平和前额叶腹内侧皮质低水平激活 来抑制负面情绪。在设计用于评估的任务阶段，预计会出现类似的模式 自动情绪调节。Face Go-no-Go任务将允许我们测试这样的假设：青少年在 内化性障碍的风险增加会表现出对恐惧和愤怒面孔的敏感性增加，并表现出 更保守的反应偏向(抑制他们对目标以外的面孔的反应)；此外 据预测，个体在右额下回表现出更多的激活，在这个区域，我们 之前发现与社交焦虑相关。该项目的发现将为我们提供新的 青春期情绪调节和调节失调的神经基础的证据，并将展示 这些过程在易受焦虑和情绪障碍影响方面的作用。