Support for Specimen Banking in ACOSOG

ACOSOG 对样本银行的支持

• 批准号: 7994946
• 负责人: DAVID M. OTA
• 金额: $ 41万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7994946
• 关键词: American College of Surgeons; American College of Surgeons Oncology Group; Clinical Trials; Clinical Trials Cooperative Group; Collection; Committee Members; Data; Ensure; Freezing; Genomics; Goals; Human; Informatics; Investigation; Malignant Neoplasms; Measures; Medicine; Molecular; Neoadjuvant Therapy; Operative Surgical Procedures; Pathology; Phase III Clinical Trials; Play; Policies; Practice Guidelines; Process; Research; Research Design; Research Proposals; Resources; Role; Site; Specimen; Testing; Training; Translational Research; Vision; Work; anticancer research; base; biobank; cancer Biomedical Informatics Grid; cancer prevention; cancer therapy; improved; programs; prospective; quality assurance; tumor

DESCRIPTION (provided by applicant): Human biospecimens are essential for translational cancer research and advancing the practice of personalized medicine. The goal of the American College of Surgeons Central Specimen Bank (ACOSOG CSB) is to leverage unique opportunities afforded by this cooperative group's clinical trial portfolio to collect and distribute human biospecimens for cancer research. This goal is achieved by three, interrelated operational objectives. First, the CSB and corresponding Central Specimen Bank and Pathology Committee (CSBPC) is responsible for oversight related to biospecimen procurement and strategies for pathology review in the context of all ACOSOG clinical trials. The CSB develops, tests, and provides physical resources (i.e. customized specimen procurement kits) and training needed for the prospective procurement of frozen biospecimens at clinical trial accrual sites. Second, the CSB ensures the proper tracking, processing, quality review, and storage of biospecimens in accordance with NCI Office of Biorepository and Biospecimen Research Best Practices Guidelines, in order to provide the highest quality biospecimens for scientific investigation. Finally, the CSB works with other ACOSOG committees to facilitate simplified access of biospecimens for translational research proposals, originating both within and external to ACOSOG. This includes making comprehensive, annotated biospecimen data available through multiple information portals and supporting a transparent and expedited process for review and administering biospecimen requests The activities and policies of the CSB support ACOSOG's scientific vision for the genomic and molecular characterization of human tumors in the context of neoadjuvant and surgical clinical trials. Furthermore, CSBPC members continue to play a significant and active role in the Group Banking Committee, particularly with respect to leading initiatives to harmonize biospecimen informatics and integrate with the NCI's caBIG(R) program. Based upon its established track record of high quality biospecimen procurement in the context of Phase III clinical trials and more recent activities in promoting cutting-edge translational research using ACOSOG biospecimens, the ACOSOG CSB will continue to make many new significant contributions to research in cancer treatment and prevention. RELEVANCE: Human biospecimens are essential for translational cancer research that ultimately leads to improved measures for cancer treatment and prevention. The goal of the ACOSOG Central Specimen Bank is to support the collection, storage, and quality assurance of biospecimens related to ACOSOG clinical trials, and to facilitate access to those biospecimens for scientific research designed to better understand the molecular and genomic basis of cancer.

描述（由申请人提供）：人类生物标本对于转化癌症研究和推进个性化医疗实践至关重要。美国外科医生学会中央标本库（ACOSOG CSB）的目标是利用该合作组织的临床试验组合提供的独特机会，收集和分发用于癌症研究的人类生物标本。这一目标通过三个相互关联的业务目标实现。首先，CSB和相应的中央标本库和病理学委员会（CSBPC）负责监督所有ACOSOG临床试验背景下的生物标本采购和病理学审查策略。CSB开发、测试并提供物理资源（即定制的标本采集试剂盒）和培训，以便在临床试验招募中心进行冷冻生物标本的预期采购。第二，CSB确保按照NCI生物储存和生物标本研究最佳实践指南办公室对生物标本进行适当的跟踪、处理、质量审查和储存，以便为科学研究提供最高质量的生物标本。最后，CSB与其他ACOSOG委员会合作，以促进简化生物标本的转化研究提案的获取，无论是在ACOSOG内部还是外部。这包括通过多个信息门户提供全面的、带注释的生物标本数据，并支持透明和快速的生物标本申请审查和管理流程。CSB的活动和政策支持ACOSOG在新辅助和外科临床试验背景下对人类肿瘤基因组和分子表征的科学愿景。此外，CSBPC成员继续在集团银行委员会中发挥重要和积极的作用，特别是在协调生物标本信息学和与NCI的caBIG（R）计划整合的主要举措方面。基于其在III期临床试验背景下的高质量生物标本采购的良好记录，以及最近在促进使用ACOSOG生物标本的尖端转化研究方面的活动，ACOSOG CSB将继续为癌症治疗和预防研究做出许多新的重大贡献。 相关性：人类生物标本对于转化癌症研究至关重要，最终导致癌症治疗和预防措施的改进。ACOSOG中央标本库的目标是支持与ACOSOG临床试验相关的生物标本的收集、储存和质量保证，并促进获得这些生物标本，用于旨在更好地了解癌症分子和基因组基础的科学研究。