ACOSOG Central Specimen Bank

描述(由申请人提供)： 美国外科医学院肿瘤学小组(ACOSOG)的使命和基础设施为临床相关科学研究的人类生物标本的收集和分析创造了相对独特的机会。该小组的外科试验重点允许预期从手术过程中收集新鲜组织样本。该小组进行的新辅助试验促进了从未接受治疗的患者收集生物标本，并在围手术期和手术后(辅助)治疗阶段收集额外的、连续计时的样本。最后，该组织以外科医生为基础的成员资格导致招募研究参与者，并相应地从大量初级、非学术医学中心收集生物标本，而这些中心在其他合作小组研究中往往没有代表。因此，ACOSOG中央标本库(ACOSOG-CSB)的目标是利用ACOSOG的这些独特功能，创建一个质量受控的生物谱库，重点放在特别适合于分子相关科学研究的冷冻组织标本。为了实现这一目标，ACOSOG-CSB及其相应的管理小组，ACOSOG组织银行小组委员会，将支持四个主要目标。首先，ACOSOG-CSB将促进从登记参加临床试验的患者中收集分子保存的生物标本。重点将放在教育和本地病理学家参与这项工作上。其次，ACOSOG-CSB将作为标本存储、加工和质量审查的中心。NCI集团银行委员会(GBC)制定的最佳实践将作为银行标准操作程序的一部分实施。第三，ACOSOG-CSB将成为集中病理审查和相关科学研究的标本分发中心。特别是，该银行现有的专业知识将被用于为相关科学研究创造可用于分析的“材料”(DNA和RNA)。第四，ACOSOG组织银行小组委员会的成员将参与GBC，提供他们在制定组织采购和信息学标准方面的独特经验，并同样受益于其他合作小组的银行专业知识。这一努力的长期结果将是该合作组织组织银行成熟为“后基因组时代”的生物标本资源。

DESCRIPTION (provided by applicant): The mission and infrastructure of the American College of Surgeons Oncology Group (ACOSOG) create relatively unique opportunities for the collection and analysis of human biospecimens for clinical correlative science studies. The group's surgical-trial focus allows for the prospective collection of fresh tissue specimens from operative procedures. Neoadjuvant trials conducted by the group facilitate the collection of biospecimens from treatment-naive patients and additional, serially timed specimens during the perioperative and post-operative (adjuvant) phase of treatment. Finally, the group's surgeon-based membership results in the recruitment of study participants and corresponding collection of biospecimens from a large number of primary, non-academic medical centers that are often not represented in other cooperative group studies. Accordingly, the goal of the ACOSOG Central Specimen Bank (ACOSOG-CSB) is to capitalize upon these unique features of ACOSOG to create a quality-controlled biospecimen repository with emphasis on frozen tissue specimens that are particularly well suited for molecular correlative science studies. To accomplish this goal, the ACOSOG-CSB and it's corresponding administrative group, the ACOSOG Tissue Bank Subcommittee, will support four main objectives. First, the ACOSOG-CSB will facilitate the collection of molecularly preserved biospecimens from patients enrolled on clinical trials. Emphasis will be placed on education and engagement of local pathologists in this effort. Second, the ACOSOG-CSB will serve as a central site for specimen storage, processing, and quality review. Best practices developed by the NCI Group Banking Committee (GBC) will be implemented as part of the bank's Standard Operating Procedures. Third, the ACOSOG-CSB will serve as a distribution center of specimens for both centralized pathology review and correlative science studies. In particular, the bank's existing expertise will be used to create assay-ready" materials (DNA and RNA) for correlative science studies. Fourth, members from the ACOSOG Tissue Bank Subcommittee will participate in the GBC, providing their unique experiences as related to developing standards for tissue procurement and informatics, and likewise benefiting from other cooperative group banking expertise. The long-term outcome of this effort will be the maturation of this Cooperative Group tissue bank into a biospecimen resource for the "post-genomic era."