ACOSOG Central Specimen Bank

描述（由申请人提供）： 美国外科医生学会肿瘤学组 (ACOSOG) 的使命和基础设施为临床相关科学研究的人类生物样本的收集和分析创造了相对独特的机会。该小组的手术试验重点是前瞻性地收集手术过程中的新鲜组织标本。该小组进行的新辅助试验有助于从初治患者收集生物样本，并在围手术期和术后（辅助）治疗阶段收集额外的、连续定时的样本。最后，该小组以外科医生为基础的成员资格导致了研究参与者的招募，并从大量初级非学术医疗中心收集了相应的生物样本，而这些中心通常在其他合作小组研究中没有代表性。因此，ACOSOG 中央样本库 (ACOSOG-CSB) 的目标是利用 ACOSOG 的这些独特功能创建一个质量受控的生物样本存储库，重点关注特别适合分子相关科学研究的冷冻组织样本。为了实现这一目标，ACOSOG-CSB 及其相应的管理小组（ACOSOG 组织库小组委员会）将支持四个主要目标。首先，ACOSOG-CSB 将有助于从参加临床试验的患者中收集分子保存的生物样本。重点将放在当地病理学家的教育和参与上。其次，ACOSOG-CSB 将作为样本存储、处理和质量审查的中心站点。 NCI 集团银行委员会 (GBC) 制定的最佳实践将作为该银行标准操作程序的一部分予以实施。第三，ACOSOG-CSB 将作为集中病理学审查和相关科学研究的标本分发中心。特别是，该银行现有的专业知识将用于为相关科学研究创建“检测就绪”材料（DNA 和 RNA）。第四，ACOSOG 组织库小组委员会的成员将参加 GBC，提供与制定组织采购和信息学标准相关的独特经验，并同样受益于其他合作组银行专业知识。这项努力的长期成果将是该合作组组织库成熟为“后基因组学”的生物样本资源。时代。”

DESCRIPTION (provided by applicant): The mission and infrastructure of the American College of Surgeons Oncology Group (ACOSOG) create relatively unique opportunities for the collection and analysis of human biospecimens for clinical correlative science studies. The group's surgical-trial focus allows for the prospective collection of fresh tissue specimens from operative procedures. Neoadjuvant trials conducted by the group facilitate the collection of biospecimens from treatment-naive patients and additional, serially timed specimens during the perioperative and post-operative (adjuvant) phase of treatment. Finally, the group's surgeon-based membership results in the recruitment of study participants and corresponding collection of biospecimens from a large number of primary, non-academic medical centers that are often not represented in other cooperative group studies. Accordingly, the goal of the ACOSOG Central Specimen Bank (ACOSOG-CSB) is to capitalize upon these unique features of ACOSOG to create a quality-controlled biospecimen repository with emphasis on frozen tissue specimens that are particularly well suited for molecular correlative science studies. To accomplish this goal, the ACOSOG-CSB and it's corresponding administrative group, the ACOSOG Tissue Bank Subcommittee, will support four main objectives. First, the ACOSOG-CSB will facilitate the collection of molecularly preserved biospecimens from patients enrolled on clinical trials. Emphasis will be placed on education and engagement of local pathologists in this effort. Second, the ACOSOG-CSB will serve as a central site for specimen storage, processing, and quality review. Best practices developed by the NCI Group Banking Committee (GBC) will be implemented as part of the bank's Standard Operating Procedures. Third, the ACOSOG-CSB will serve as a distribution center of specimens for both centralized pathology review and correlative science studies. In particular, the bank's existing expertise will be used to create assay-ready" materials (DNA and RNA) for correlative science studies. Fourth, members from the ACOSOG Tissue Bank Subcommittee will participate in the GBC, providing their unique experiences as related to developing standards for tissue procurement and informatics, and likewise benefiting from other cooperative group banking expertise. The long-term outcome of this effort will be the maturation of this Cooperative Group tissue bank into a biospecimen resource for the "post-genomic era."