ACOSOG Central Specimen Bank

ACOSOG 中央样本库

• 批准号: 7120108
• 负责人: DAVID M. OTA
• 金额: $ 55.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120108
• 关键词: ACOSOG; Central; Specimen; Bank

DESCRIPTION (provided by applicant): The mission and infrastructure of the American College of Surgeons Oncology Group (ACOSOG) create relatively unique opportunities for the collection and analysis of human biospecimens for clinical correlative science studies. The group's surgical-trial focus allows for the prospective collection of fresh tissue specimens from operative procedures. Neoadjuvant trials conducted by the group facilitate the collection of biospecimens from treatment-naive patients and additional, serially timed specimens during the perioperative and post-operative (adjuvant) phase of treatment. Finally, the group's surgeon-based membership results in the recruitment of study participants and corresponding collection of biospecimens from a large number of primary, non-academic medical centers that are often not represented in other cooperative group studies. Accordingly, the goal of the ACOSOG Central Specimen Bank (ACOSOG-CSB) is to capitalize upon these unique features of ACOSOG to create a quality-controlled biospecimen repository with emphasis on frozen tissue specimens that are particularly well suited for molecular correlative science studies. To accomplish this goal, the ACOSOG-CSB and it's corresponding administrative group, the ACOSOG Tissue Bank Subcommittee, will support four main objectives. First, the ACOSOG-CSB will facilitate the collection of molecularly preserved biospecimens from patients enrolled on clinical trials. Emphasis will be placed on education and engagement of local pathologists in this effort. Second, the ACOSOG-CSB will serve as a central site for specimen storage, processing, and quality review. Best practices developed by the NCI Group Banking Committee (GBC) will be implemented as part of the bank's Standard Operating Procedures. Third, the ACOSOG-CSB will serve as a distribution center of specimens for both centralized pathology review and correlative science studies. In particular, the bank's existing expertise will be used to create assay-ready" materials (DNA and RNA) for correlative science studies. Fourth, members from the ACOSOG Tissue Bank Subcommittee will participate in the GBC, providing their unique experiences as related to developing standards for tissue procurement and informatics, and likewise benefiting from other cooperative group banking expertise. The long-term outcome of this effort will be the maturation of this Cooperative Group tissue bank into a biospecimen resource for the "post-genomic era."

描述（由申请人提供）： 美国外科医师学会肿瘤组（ACOSOG）的使命和基础设施为临床相关科学研究的人体生物标本的收集和分析创造了相对独特的机会。该组织的医学试验重点允许从手术过程中前瞻性地收集新鲜组织标本。该小组进行的新辅助治疗试验有助于从初治患者中采集生物标本，并在围手术期和术后（辅助治疗）阶段采集额外的连续时间标本。最后，该小组的外科医生为基础的成员资格的研究参与者的招聘和相应的生物标本的收集，从大量的主要，非学术的医疗中心，往往不代表在其他合作小组的研究。因此，ACOSOG中央标本库（ACOSOG-CSB）的目标是利用ACOSOG的这些独特功能，创建一个质量受控的生物标本库，重点是特别适合分子相关科学研究的冷冻组织标本。为了实现这一目标，ACOSOG-CSB及其相应的行政小组，ACOSOG组织库小组委员会，将支持四个主要目标。首先，ACOSOG-CSB将促进从参加临床试验的患者中收集分子保存的生物标本。重点将放在教育和当地病理学家参与这一努力。其次，ACOSOG-CSB将作为标本储存、处理和质量审查的中心地点。NCI集团银行委员会（GBC）制定的最佳做法将作为银行标准操作程序的一部分实施。第三，ACOSOG-CSB将作为标本的分发中心，用于集中病理学审查和相关科学研究。特别是，该银行现有的专业知识将用于为相关科学研究创建“检测就绪”材料（DNA和RNA）。第四，来自ACOSOG组织库小组委员会的成员将参加GBC，提供他们在制定组织采购和信息学标准方面的独特经验，并同样受益于其他合作团体的银行专业知识。这一努力的长期结果将是使该合作组组织库成熟为“后基因组时代”的生物标本资源。"