ACOSOG Competing Renewal

描述(由申请人提供)： 美国外科医师学会肿瘤学小组(ACOSOG)致力于通过一项创新的临床研究计划改善外科肿瘤患者的护理，以达到三个具体目标：1.测试可提高响应率和治愈率的新疗法，并减少与癌症护理相关的发病率和残疾。2.结合临床试验进行基础科学研究，以更好地了解疾病和治疗的生物学基础。3.支持个人成员和研究人员网络让患者参加试验，并履行ACOSOG的科学使命。ACOSOG的科学组合专注于特定于分子和图像分析、新辅助疗法以及靶向或新型手术疗法的研究。有四个科学委员会，包括一个基础科学委员会和三个疾病委员会：乳房、胃肠道(GIST、胰腺和直肠)和胸科(肺和食道)。ACOSOG试验的三个科学目标包括：a)通过成像和分子图谱分析提高预测的准确性，从而加强风险分层；b)通过新辅助疗法的应用，提高总体缓解率并监测个体反应；c)研究新颖的、有针对性的手术疗法，以维持肿瘤学结果，同时减少毒性和残疾，从而提高生活质量。为了制定ACOSOG的科学议程，疾病委员会与基础科学委员会合作，在适当的情况下确保以科学为导向的试验的发展。科学委员会还与行政委员会&同行审查和优先排序委员会密切合作，以确保成员支持以及优先次序、协调和高质量的科学。所有学科以及护理和患者倡导者都有代表，并通过同行审查委员会的过程提供礼仪反馈。基础科学委员会和ACOSOG Biosecimen Bank确保适当地获取和存储样本，以进行整合到每项临床试验中的科学研究。为了实现科学目标，ACOSOG使用由五个关键组成部分组成的基础设施进行临床试验，其中包括：1)位于北卡罗来纳州达勒姆的杜克临床研究所内的行政协调中心(ACC或运营办公室)；2)位于明尼苏达州罗切斯特的梅奥临床癌症中心内的生物统计学；3)科学和组织方面的领导；4)成员和网络；5)华盛顿大学内位于密苏里州圣路易斯的生物医学银行。

DESCRIPTION (provided by applicant): The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase response rates and cure rates and reduce morbidities and disabilities associated with cancer care. 2. To conduct basic science studies in conjunction with clinical trials to better understand the biologic basis of diseases and treatments. 3. To support individual members and investigator networks to accrue patients to trials and fulfill the scientific mission of ACOSOG. The scientific portfolio of ACOSOG is focused on investigations specific to molecular and image profiling, neoadjuvant therapies, and targeted or novel surgical therapies. There are four scientific committees including a Basic Science Committee and three disease committees: Breast, Gastrointestinal (GIST, pancreas, and rectum) and Thoracic (lung and esophagus). Three scientific aims are described for ACOSOG trials including: a) to enhance risk stratification by increasing the accuracy of prognostication through imaging and molecular profiling; b) to improve overall response rates and monitor individual responses through the application of neoadjuvant therapies; and c) to investigate novel, targeted, and surgical therapies to maintain oncologic outcomes while reducing toxicities and disabilities thereby improving quality of life. To set the scientific agenda of ACOSOG, the disease committees work with the Basic Science Committee to ensure, where appropriate, the development of science-driven trials. The scientific committees also work closely with the administrative committees & the Peer-Review and Prioritization Committee to ensure membership support as well as prioritization, coordination, and quality science. All disciplines as well as Nursing & Patient Advocates are represented and provide protocol feedback through the Peer-Review Committee process. The Basic Science Committee & ACOSOG Biospecimen Bank ensure the appropriate acquisition and storage of samples to conduct the scientific studies integrated into each clinical trial. To accomplish the scientific aims, ACOSOG conducts clinical trials using an infrastructure consisting of five critical components, including the: 1) Administrative Coordinating Center (ACC or Operations Office) located in Durham, NC within the Duke Clinical Research Institute; 2) Biostatistics, located in Rochester, MN, within the Mayo Clinical Cancer Center; 3) Leadership, both scientific and organizational; 4) Membership and Networks; and 5) the Biospecimen Bank located in St. Louis, MO, within Washington University.