ACOSOG Competing Renewal

ACOSOG 竞争更新

• 批准号: 7351252
• 负责人: DAVID M. OTA
• 金额: $ 301.12万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7351252
• 关键词: ACOSOG; Competing; Renewal

DESCRIPTION (provided by applicant): The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase response rates and cure rates and reduce morbidities and disabilities associated with cancer care. 2. To conduct basic science studies in conjunction with clinical trials to better understand the biologic basis of diseases and treatments. 3. To support individual members and investigator networks to accrue patients to trials and fulfill the scientific mission of ACOSOG. The scientific portfolio of ACOSOG is focused on investigations specific to molecular and image profiling, neoadjuvant therapies, and targeted or novel surgical therapies. There are four scientific committees including a Basic Science Committee and three disease committees: Breast, Gastrointestinal (GIST, pancreas, and rectum) and Thoracic (lung and esophagus). Three scientific aims are described for ACOSOG trials including: a) to enhance risk stratification by increasing the accuracy of prognostication through imaging and molecular profiling; b) to improve overall response rates and monitor individual responses through the application of neoadjuvant therapies; and c) to investigate novel, targeted, and surgical therapies to maintain oncologic outcomes while reducing toxicities and disabilities thereby improving quality of life. To set the scientific agenda of ACOSOG, the disease committees work with the Basic Science Committee to ensure, where appropriate, the development of science-driven trials. The scientific committees also work closely with the administrative committees & the Peer-Review and Prioritization Committee to ensure membership support as well as prioritization, coordination, and quality science. All disciplines as well as Nursing & Patient Advocates are represented and provide protocol feedback through the Peer-Review Committee process. The Basic Science Committee & ACOSOG Biospecimen Bank ensure the appropriate acquisition and storage of samples to conduct the scientific studies integrated into each clinical trial. To accomplish the scientific aims, ACOSOG conducts clinical trials using an infrastructure consisting of five critical components, including the: 1) Administrative Coordinating Center (ACC or Operations Office) located in Durham, NC within the Duke Clinical Research Institute; 2) Biostatistics, located in Rochester, MN, within the Mayo Clinical Cancer Center; 3) Leadership, both scientific and organizational; 4) Membership and Networks; and 5) the Biospecimen Bank located in St. Louis, MO, within Washington University.

描述（由申请人提供）： 美国外科医生肿瘤学会（ACOSOG）致力于通过创新的临床研究计划来改善外科肿瘤患者的护理，该计划涉及三个具体目标：1。测试新的疗法，可能会增加反应率和治愈率，并减少与癌症护理相关的发病率和残疾。2.进行基础科学研究与临床试验，以更好地了解疾病和治疗的生物学基础。3.支持个人成员和研究者网络招募患者参加试验，并履行ACOSOG的科学使命。ACOSOG的科学组合专注于分子和图像分析，新辅助治疗和靶向或新型外科治疗的研究。有四个科学委员会，包括一个基础科学委员会和三个疾病委员会：乳腺，胃肠道（GIST，胰腺和直肠）和胸部（肺和食管）。ACOSOG试验描述了三个科学目的，包括：a）通过影像学和分子分析提高诊断的准确性，从而加强风险分层; B）通过应用新辅助治疗提高总体缓解率并监测个体缓解;和c）研究新的，有针对性的，和手术治疗，以维持肿瘤学结果，同时减少毒性和残疾，从而改善生活质量。为了制定ACOSOG的科学议程，疾病委员会与基础科学委员会合作，确保在适当的情况下开展科学驱动的试验。科学委员会还与行政委员会和同行评审和优先级委员会密切合作，以确保成员支持以及优先级，协调和质量科学。所有学科以及护理和患者倡导者都有代表，并通过同行评审委员会流程提供方案反馈。基础科学委员会和ACOSOG生物样本库确保样本的适当采集和储存，以进行整合到每个临床试验中的科学研究。为了实现科学目标，ACOSOG使用由五个关键组成部分组成的基础设施进行临床试验，包括：1）行政协调中心（ACC或运营办公室），位于杜克临床研究所内的达勒姆，NC; 2）生物统计学，位于罗切斯特，MN，马约临床癌症中心内; 3）科学和组织领导力; 4）会员和网络;和5）生物标本库位于圣路易斯，密苏里州，在华盛顿大学。