ECOG Specimen Banking

描述(由申请人提供)：ECOG组织库是ECOG翻译科学计划的重要组成部分，为ECOG成员和非成员机构的研究人员提供了宝贵的资源。这项申请建议继续支持这些银行的协调和运作，目的是收集、处理和存储高质量的标本，并使它们可供研究人员用于经批准的相关科学项目。ECOG将增加其高质量库存标本的营销，用于尖端研究，这反过来将改变临床护理。ECOG是NCI-临床试验合作集团集团银行委员会(GBC)的积极参与者，并致力于通过ECOG在指导委员会和小组委员会的代表与GBC合作，朝着在所有合作集团银行收集、处理、存储和分发样本的统一系统的共同目标努力。通用技术的使用确保了样本具有足够的质量用于尖端研究，便于为大型翻译项目汇集来自多个银行的样本，并增强了跨项目比较结果的能力。通用词汇表和数据结构以及样本请求的通用策略使所有调查人员更容易导航系统，而无论合作小组的成员身份如何。这创造了一个合作的、强大的和富有成效的癌症研究系统。ECOG的三个主要标本库是实体肿瘤库(ECOG PCO-RL)、白血病组织库和骨髓瘤组织库。每个中心都根据严格的SOP(基于推荐的最佳实践)从合作集团的临床试验中收集和存储经过良好注释的样本，并遵循GBC实践将其提供给研究人员。 相关性：来自大型合作小组试验的库生物标本，带有临床注释和相关的随访数据，可用于许多研究项目。最重要的项目是那些识别或验证生物标志物的项目；这些生物标志物是可用于预测治疗反应的基因或蛋白质。因此，ECOG库中注解良好的标本可用于推进个体化治疗的使命。

DESCRIPTION (provided by applicant): The ECOG tissue banks are a critical part of ECOG's translational science program, providing a valuable resource to investigators at both ECOG member and non-member institutions. This application proposes continued support for the coordination and operation of these banks with the goal of collecting, processing, and storing high-quality specimens and making them available to investigators for use in approved correlative science projects. ECOG will increase the marketing of its high quality banked specimens for use in cutting edge research which in turn will change clinical care. ECOG is an active participant in the NCI-Clinical Trials Cooperative Groups' Group Banking Committee (GBC) and is committed to working with the GBC, through ECOG representation on the Steering Committee and subcommittees, toward the common goal of a harmonized system for the collection, processing, storage, and distribution of specimens across all Cooperative Group Banks. The use of common techniques ensures that samples are of sufficient quality for use in cutting edge research, facilitates pooling specimens from multiple banks for large scale translational projects, and enhances the ability to compare results across projects. Common vocabularies and data structures, as well as common policies for specimen requests, make the system easier to navigate for ail investigators regardless of cooperative group membership status. This creates a collegial, robust and productive cancer research system. The three main ECOG specimen banks are the Solid Tumor Bank (the ECOG PCO-RL), the Leukemia Tissue Bank, and the Myeloma Tissue Bank. Each collects and banks well annotated specimens from Cooperative Group clinical trials according to strict SOPs based on recommended Best Practices and follows GBC practices to make them available to investigators. RELEVANCE: Banked biospecimens from large cooperative group trials, with clinical annotation and linked follow-up data, can be used for many research projects. The most important projects are those which identify or validate biomarkers; genes or proteins which can be used to predict responses to treatment. The well annotated specimens in the ECOG banks can thus be used to further the mission of individualized therapy.